Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22833195
TITLE
Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking.
ABSTRACT
The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures of excitement-seeking are more likely to smoke, use other drugs, gamble, drive recklessly, have unsafe/unprotected sex and engage in other risky behaviors of clinical and social relevance. To identify common genetic variants associated with the Excitement-Seeking scale of the Revised NEO Personality Inventory, we performed genome-wide association studies in six samples of European ancestry (N=7860), and combined the results in a meta-analysis. We identified a genome-wide significant association between the Excitement-Seeking scale and rs7600563 (P=2 × 10(-8)). This single-nucleotide polymorphism maps within the catenin cadherin-associated protein, alpha 2 (CTNNA2) gene, which encodes for a brain-expressed α-catenin critical for synaptic contact. The effect of rs7600563 was in the same direction in all six samples, but did not replicate in additional samples (N=5105). The results provide insight into the genetics of excitement-seeking and risk-taking, and are relevant to hyperactivity, substance use, antisocial and bipolar disorders.
DATE PUBLISHED
2011
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/07/27 06:00
pubmed 2011/01/01 00:00
medline 2013/04/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Terracciano A Terracciano A A National Institute on Aging, NIH, DHHS, Baltimore, MD 21224, USA. Terraccianoa@mail.nih.gov
Esko T Esko T T
Sutin AR Sutin A R AR
de Moor MH de Moor M H M MH
Meirelles O Meirelles O O
Zhu G Zhu G G
Tanaka T Tanaka T T
Giegling I Giegling I I
Nutile T Nutile T T
Realo A Realo A A
Allik J Allik J J
Hansell NK Hansell N K NK
Wright MJ Wright M J MJ
Montgomery GW Montgomery G W GW
Willemsen G Willemsen G G
Hottenga JJ Hottenga J-J JJ
Friedl M Friedl M M
Ruggiero D Ruggiero D D
Sorice R Sorice R R
Sanna S Sanna S S
Cannas A Cannas A A
Räikkönen K Räikkönen K K
Widen E Widen E E
Palotie A Palotie A A
Eriksson JG Eriksson J G JG
Cucca F Cucca F F
Krueger RF Krueger R F RF
Lahti J Lahti J J
Luciano M Luciano M M
Smoller JW Smoller J W JW
van Duijn CM van Duijn C M CM
Abecasis GR Abecasis G R GR
Boomsma DI Boomsma D I DI
Ciullo M Ciullo M M
Costa PT Jr Costa P T PT
Ferrucci L Ferrucci L L
Martin NG Martin N G NG
Metspalu A Metspalu A A
Rujescu D Rujescu D D
Schlessinger D Schlessinger D D
Uda M Uda M M
INVESTIGATORS
JOURNAL
VOLUME: 1
ISSUE:
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2011
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
Intramural NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Australia epidemiology
Baltimore epidemiology
Estonia epidemiology
Female epidemiology
Finland epidemiology
Genetic Variation epidemiology
Genome-Wide Association Study methods
Germany epidemiology
Humans epidemiology
Italy epidemiology
Longitudinal Studies epidemiology
Male epidemiology
Middle Aged epidemiology
Netherlands epidemiology
Polymorphism, Single Nucleotide genetics
Psychomotor Agitation metabolism
Young Adult metabolism
alpha Catenin genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 CTNNA2 protein, human
0 alpha Catenin
OTHER ID's
OTHERID SOURCE
PMC3309493 NLM