Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22823124
TITLE
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
ABSTRACT
While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use.
2012 The Authors, Addiction Biology 2012 Society for the Study of Addiction.
DATE PUBLISHED
2013 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2012/07/24
entrez 2012/07/25 06:00
pubmed 2012/07/25 06:00
medline 2014/03/13 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Verweij KJ Verweij Karin J H KJ Queensland Institute of Medical Research, Australia. karin.verweij@qimr.edu.au
Vinkhuyzen AA Vinkhuyzen Anna A E AA
Benyamin B Benyamin Beben B
Lynskey MT Lynskey Michael T MT
Quaye L Quaye Lydia L
Agrawal A Agrawal Arpana A
Gordon SD Gordon Scott D SD
Montgomery GW Montgomery Grant W GW
Madden PA Madden Pamela A F PA
Heath AC Heath Andrew C AC
Spector TD Spector Timothy D TD
Martin NG Martin Nicholas G NG
Medland SE Medland Sarah E SE
INVESTIGATORS
JOURNAL
VOLUME: 18
ISSUE: 5
TITLE: Addiction biology
ISOABBREVIATION: Addict Biol
YEAR: 2013
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1369-1600
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Addict Biol
COUNTRY: United States
ISSNLINKING: 1355-6215
NLMUNIQUEID: 9604935
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA013321 NIAAA NIH HHS United States
AA013326 NIAAA NIH HHS United States
AA014041 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
DA12854 NIDA NIH HHS United States
DA23668 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 AA013326 NIAAA NIH HHS United States
R01 AA014041 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
KEYWORD
Association
cannabis
genetics
heritability
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia epidemiology
Female epidemiology
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Genotype genetics
Great Britain epidemiology
Humans epidemiology
Male epidemiology
Marijuana Abuse genetics
Middle Aged genetics
Polymorphism, Single Nucleotide genetics
Twin Studies as Topic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS386898 NLM
PMC3548058 NLM