Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22754043
TITLE
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
ABSTRACT
OBJECTIVES NlmCategory: OBJECTIVE
To identify common genetic variants that predispose to caffeine-induced insomnia and to test whether genes whose expression changes in the presence of caffeine are enriched for association with caffeine-induced insomnia.
DESIGN NlmCategory: METHODS
A hypothesis-free, genome-wide association study.
SETTING NlmCategory: METHODS
Community-based sample of Australian twins from the Australian Twin Registry.
PARTICIPANTS NlmCategory: METHODS
After removal of individuals who said that they do not drink coffee, a total of 2,402 individuals from 1,470 families in the Australian Twin Registry provided both phenotype and genotype information.
MEASUREMENTS AND RESULTS NlmCategory: RESULTS
A dichotomized scale based on whether participants reported ever or never experiencing caffeine-induced insomnia. A factor score based on responses to a number of questions regarding normal sleep habits was included as a covariate in the analysis. More than 2 million common single nucleotide polymorphisms (SNPs) were tested for association with caffeine-induced insomnia. No SNPs reached the genome-wide significance threshold. In the analysis that did not include the insomnia factor score as a covariate, the most significant SNP identified was an intronic SNP in the PRIMA1 gene (P = 1.4 × 10⁻⁶, odds ratio = 0.68 [0.53 - 0.89]). An intergenic SNP near the GBP4 gene on chromosome 1 was the most significant upon inclusion of the insomnia factor score into the model (P = 1.9 × 10⁻⁶, odds ratio = 0.70 [0.62 - 0.78]). A previously identified association with a polymorphism in the ADORA2A gene was replicated.
CONCLUSIONS NlmCategory: CONCLUSIONS
Several genes have been identified in the study as potentially influencing caffeine-induced insomnia. They will require replication in another sample. The results may have implications for understanding the biologic mechanisms underlying insomnia.
DATE PUBLISHED
2012 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/07/04 06:00
pubmed 2012/07/04 06:00
medline 2012/11/14 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Byrne EM Byrne Enda M EM Queensland Institute of Medical Research, Brisbane, Australia. enda.byrne@qimr.edu.au
Johnson J Johnson Julie J
McRae AF McRae Allan F AF
Nyholt DR Nyholt Dale R DR
Medland SE Medland Sarah E SE
Gehrman PR Gehrman Philip R PR
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
Montgomery GW Montgomery Grant W GW
Chenevix-Trench G Chenevix-Trench Georgia G
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 35
ISSUE: 7
TITLE: Sleep
ISOABBREVIATION: Sleep
YEAR: 2012
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1550-9109
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Sleep
COUNTRY: United States
ISSNLINKING: 0161-8105
NLMUNIQUEID: 7809084
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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CommentIn Sleep. 2012 Jul;35(7):899-900 22754033
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH66206 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Caffeine
genetics
insomnia
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Caffeine adverse effects
Female adverse effects
Gene Expression Profiling adverse effects
Genome-Wide Association Study adverse effects
Genotype adverse effects
Humans adverse effects
Male adverse effects
Membrane Proteins physiology
Nerve Tissue Proteins physiology
Polymorphism, Single Nucleotide genetics
Receptor, Adenosine A2A physiology
Sleep Wake Disorders genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Membrane Proteins
0 Nerve Tissue Proteins
0 PRIMA1 protein, human
0 Receptor, Adenosine A2A
3G6A5W338E Caffeine
OTHER ID's
OTHERID SOURCE
PMC3369232 NLM