| PMID |
|
|
| TITLE |
|
| Modeling the direction of causation between cross-sectional measures of disrupted sleep, anxiety and depression in a sample of male and female Australian twins. |
|
| ABSTRACT |
|
|
|
| The direction of causation between measures of disrupted sleep, anxiety and depression is not well understood. Under certain conditions, cross-sectional analysis based on genetically informative data can provide important information about the direction of causation between variables. Two community-based samples of 7235 Australian twins aged 18-87 years were mailed an extensive questionnaire that covered a wide range of personality and behavioral measures. Included were self-report measures of disrupted sleep, as well as symptoms of anxiety and depression. Among all females, modeling the direction of causation did not support the hypothesis of sleep having a direct causal impact on risk of anxiety or depression. Among older females, we found evidence that both anxiety and depression interact reciprocally with disrupted sleep, whereas among younger women both anxiety and depression appear to have a causal impact on sleep. Results for males were equivocal. The nosological implications of our findings are discussed. |
| © 2012 European Sleep Research Society. |
|
| DATE PUBLISHED |
|
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2012/06/27 |
| entrez |
2012/06/29 06:00 |
| pubmed |
2012/06/29 06:00 |
| medline |
2013/05/18 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Queensland Institute of Medical Research, Brisbane, Qld, Australia. ngillespie@vcu.edu |
| Gehrman P |
|
Gehrman |
Philip |
P |
|
|
| Byrne EM |
|
Byrne |
Enda M |
EM |
|
|
| Kendler KS |
|
Kendler |
Kenneth S |
KS |
|
|
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 21 |
| ISSUE: 6 |
| TITLE: Journal of sleep research |
| ISOABBREVIATION: J Sleep Res |
| YEAR: 2012 |
| MONTH: Dec |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1365-2869 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: J Sleep Res |
| COUNTRY: England |
| ISSNLINKING: 0962-1105 |
| NLMUNIQUEID: 9214441 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 1K99DA023549-01A2 |
NIDA NIH HHS |
United States |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| AA13326 |
NIAAA NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| P50 AA011998 |
NIAAA NIH HHS |
United States |
| R00 DA023549 |
NIDA NIH HHS |
United States |
| R00DA023549 |
NIDA NIH HHS |
United States |
| R01 AA007535 |
NIAAA NIH HHS |
United States |
| R01 AA007728 |
NIAAA NIH HHS |
United States |
| R01 AA010249 |
NIAAA NIH HHS |
United States |
| R01 AA013321 |
NIAAA NIH HHS |
United States |
| R01 AA013326 |
NIAAA NIH HHS |
United States |
| R21 MH079187 |
NIMH NIH HHS |
United States |
| R21-MH-079187 |
NIMH NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Age Factors |
|
| Aged |
|
| Aged, 80 and over |
|
| Anxiety |
genetics |
| Australia |
epidemiology |
| Cohort Studies |
epidemiology |
| Comorbidity |
epidemiology |
| Cross-Sectional Studies |
epidemiology |
| Depression |
genetics |
| Diseases in Twins |
genetics |
| Female |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Personality |
genetics |
| Psychiatric Status Rating Scales |
genetics |
| Registries |
genetics |
| Risk |
genetics |
| Sex Factors |
genetics |
| Sleep |
genetics |
| Sleep Wake Disorders |
genetics |
| Surveys and Questionnaires |
genetics |
| Young Adult |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS375798 |
NLM |
| PMC3461239 |
NLM |
|
