Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22738694
TITLE
Modeling the direction of causation between cross-sectional measures of disrupted sleep, anxiety and depression in a sample of male and female Australian twins.
ABSTRACT
The direction of causation between measures of disrupted sleep, anxiety and depression is not well understood. Under certain conditions, cross-sectional analysis based on genetically informative data can provide important information about the direction of causation between variables. Two community-based samples of 7235 Australian twins aged 18-87 years were mailed an extensive questionnaire that covered a wide range of personality and behavioral measures. Included were self-report measures of disrupted sleep, as well as symptoms of anxiety and depression. Among all females, modeling the direction of causation did not support the hypothesis of sleep having a direct causal impact on risk of anxiety or depression. Among older females, we found evidence that both anxiety and depression interact reciprocally with disrupted sleep, whereas among younger women both anxiety and depression appear to have a causal impact on sleep. Results for males were equivocal. The nosological implications of our findings are discussed.
2012 European Sleep Research Society.
DATE PUBLISHED
2012 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2012/06/27
entrez 2012/06/29 06:00
pubmed 2012/06/29 06:00
medline 2013/05/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Gillespie NA Gillespie Nathan A NA Queensland Institute of Medical Research, Brisbane, Qld, Australia. ngillespie@vcu.edu
Gehrman P Gehrman Philip P
Byrne EM Byrne Enda M EM
Kendler KS Kendler Kenneth S KS
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 21
ISSUE: 6
TITLE: Journal of sleep research
ISOABBREVIATION: J Sleep Res
YEAR: 2012
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1365-2869
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Sleep Res
COUNTRY: England
ISSNLINKING: 0962-1105
NLMUNIQUEID: 9214441
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
1K99DA023549-01A2 NIDA NIH HHS United States
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
R00 DA023549 NIDA NIH HHS United States
R00DA023549 NIDA NIH HHS United States
R01 AA007535 NIAAA NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 AA013326 NIAAA NIH HHS United States
R21 MH079187 NIMH NIH HHS United States
R21-MH-079187 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Anxiety genetics
Australia epidemiology
Cohort Studies epidemiology
Comorbidity epidemiology
Cross-Sectional Studies epidemiology
Depression genetics
Diseases in Twins genetics
Female genetics
Humans genetics
Male genetics
Middle Aged genetics
Personality genetics
Psychiatric Status Rating Scales genetics
Registries genetics
Risk genetics
Sex Factors genetics
Sleep genetics
Sleep Wake Disorders genetics
Surveys and Questionnaires genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS375798 NLM
PMC3461239 NLM