Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22683712
TITLE
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
ABSTRACT
Migraine without aura is the most common form of migraine, characterized by recurrent disabling headache and associated autonomic symptoms. To identify common genetic variants associated with this migraine type, we analyzed genome-wide association data of 2,326 clinic-based German and Dutch individuals with migraine without aura and 4,580 population-matched controls. We selected SNPs from 12 loci with 2 or more SNPs associated with P values of <1 × 10(-5) for replication testing in 2,508 individuals with migraine without aura and 2,652 controls. SNPs at two of these loci showed convincing replication: at 1q22 (in MEF2D; replication P = 4.9 × 10(-4); combined P = 7.06 × 10(-11)) and at 3p24 (near TGFBR2; replication P = 1.0 × 10(-4); combined P = 1.17 × 10(-9)). In addition, SNPs at the PHACTR1 and ASTN2 loci showed suggestive evidence of replication (P = 0.01; combined P = 3.20 × 10(-8) and P = 0.02; combined P = 3.86 × 10(-8), respectively). We also replicated associations at two previously reported migraine loci in or near TRPM8 and LRP1. This study identifies the first susceptibility loci for migraine without aura, thereby expanding our knowledge of this debilitating neurological disorder.
DATE PUBLISHED
2012 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/12/13
accepted 2012/05/03
aheadofprint 2012/06/10
entrez 2012/06/12 06:00
pubmed 2012/06/12 06:00
medline 2012/11/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Freilinger T Freilinger Tobias T Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.
Anttila V Anttila Verneri V
de Vries B de Vries Boukje B
Malik R Malik Rainer R
Kallela M Kallela Mikko M
Terwindt GM Terwindt Gisela M GM
Pozo-Rosich P Pozo-Rosich Patricia P
Winsvold B Winsvold Bendik B
Nyholt DR Nyholt Dale R DR
van Oosterhout WP van Oosterhout Willebrordus P J WP
Artto V Artto Ville V
Todt U Todt Unda U
Hämäläinen E Hämäläinen Eija E
Fernández-Morales J Fernández-Morales Jèssica J
Louter MA Louter Mark A MA
Kaunisto MA Kaunisto Mari A MA
Schoenen J Schoenen Jean J
Raitakari O Raitakari Olli O
Lehtimäki T Lehtimäki Terho T
Vila-Pueyo M Vila-Pueyo Marta M
Göbel H Göbel Hartmut H
Wichmann E Wichmann Erich E
Sintas C Sintas Cèlia C
Uitterlinden AG Uitterlinden Andre G AG
Hofman A Hofman Albert A
Rivadeneira F Rivadeneira Fernando F
Heinze A Heinze Axel A
Tronvik E Tronvik Erling E
van Duijn CM van Duijn Cornelia M CM
Kaprio J Kaprio Jaakko J
Cormand B Cormand Bru B
Wessman M Wessman Maija M
Frants RR Frants Rune R RR
Meitinger T Meitinger Thomas T
Müller-Myhsok B Müller-Myhsok Bertram B
Zwart JA Zwart John-Anker JA
Färkkilä M Färkkilä Markus M
Macaya A Macaya Alfons A
Ferrari MD Ferrari Michel D MD
Kubisch C Kubisch Christian C
Palotie A Palotie Aarno A
Dichgans M Dichgans Martin M
van den Maagdenberg AM van den Maagdenberg Arn M J M AM
International Headache Genetics Consortium
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Anttila Verneri V
Artto Ville V
Borck Guntram G
Calafato Stella S
Cormand Bru B
Dichgans Martin M
Färkkilä Markus M
Fernández-Morales Jèssica J
Ferrari Michel D MD
Frants Rune R RR
Freilinger Tobias T
Gormley Padhraig P
Hämäläinen Eija E
Kallela Mikko M
Kubisch Christian C
van den Maagdenberg Arn M J M AM
Macaya Alfons A
Malik Rainer R
Müller-Myhsok Bertram B
Nyholt Dale R DR
Palotie Aarno A
Palta Priit P
Pozo-Rosich Patricia P
Selmer Kaja K KK
Stefansson Hreinn H
Terwindt Gisela M GM
Todt Unda U
de Vries Boukje B
Wessman Maija M
Winsvold Bendik B
Zwart John-Anker JA
JOURNAL
VOLUME: 44
ISSUE: 7
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2012
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Brain. 2009 Jan;132(Pt 1):16-25 19052139
Cites Brain Res Mol Brain Res. 1996 Dec;42(2):307-16 9013788
Cites Neuron. 2009 Mar 12;61(5):762-73 19285472
Cites PLoS Genet. 2009 Jun;5(6):e1000529 19543373
Cites Cephalalgia. 2009 Sep;29(9):987-96 19689607
Cites Eur J Neurol. 2001 Sep;8(5):441-9 11554907
Cites N Engl J Med. 2002 Jan 24;346(4):257-70 11807151
Cites Stat Med. 2002 Jun 15;21(11):1539-58 12111919
Cites JAMA. 2004 Jan 28;291(4):427-34 14747499
Cites Proc Natl Acad Sci U S A. 2004 May 4;101(18):7187-92 15107502
Cites Mol Cell Biol. 2004 Oct;24(20):8872-83 15456862
Cites Control Clin Trials. 1986 Sep;7(3):177-88 3802833
Cites Neurology. 1990 Oct;40(10):1582-6 1977102
Cites Cell. 1992 Feb 21;68(4):775-85 1310899
Cites Cephalalgia. 1993 Apr;13(2):89-93 8098663
Cites Cephalalgia. 1996 Jun;16(4):239-45 8792035
Cites Neuron. 1999 Jul;23(3):435-47 10433257
Cites Neurology. 1999 Aug 11;53(3):537-42 10449117
Cites Science. 2006 Feb 17;311(5763):1008-12 16484497
Cites Eur J Neurol. 2006 Apr;13(4):333-45 16643310
Cites Curr Biol. 2006 Aug 22;16(16):1591-605 16920620
Cites J Med Genet. 2006 Dec;43(12):908-16 16885183
Cites Cephalalgia. 2007 Mar;27(3):193-210 17381554
Cites Am J Hum Genet. 2007 Sep;81(3):559-75 17701901
Cites Cephalalgia. 2007 Sep;27(9):995-9 17727472
Cites PLoS One. 2007;2(9):e841 17786212
Cites Nat Genet. 2007 Oct;39(10):1217-24 17873874
Cites Nature. 2007 Oct 18;449(7164):851-61 17943122
Cites Neurology. 2007 Nov 20;69(21):1990-5 18025393
Cites Cephalalgia. 2007 Dec;27(12):1442-53 18034688
Cites Science. 2008 Jul 11;321(5886):218-23 18621663
Cites Physiol Rev. 2008 Jul;88(3):887-918 18626063
Cites Neuron. 2008 Dec 26;60(6):1022-38 19109909
Cites Science. 2009 Sep 4;325(5945):1246-50 19644074
Cites PLoS One. 2009;4(10):e7383 19812688
Cites Neuron. 2010 Apr 29;66(2):191-7 20434996
Cites Neurol Sci. 2010 Jun;31 Suppl 1:S159-61 20464611
Cites J Neurosci. 2010 Jun 23;30(25):8529-40 20573900
Cites BMC Bioinformatics. 2010;11:288 20509871
Cites Nature. 2010 Sep 2;467(7311):52-8 20811451
Cites Nat Genet. 2010 Oct;42(10):869-73 20802479
Cites PLoS Genet. 2011;7(2):e1002003 21304890
Cites Cephalalgia. 2011 Jun;31(8):886-96 21511950
Cites Nat Genet. 2011 Jul;43(7):695-8 21666692
Cites Biochimie. 2011 Oct;93(10):1668-75 21798305
Cites Neurobiol Dis. 2012 Jan;45(1):633-44 22033344
Cites Nat Genet. 2009 Mar;41(3):334-41 19198609
GRANTS
GRANTID AGENCY COUNTRY
098051 Wellcome Trust United Kingdom
098051 Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Case-Control Studies
Female
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study methods
Humans methods
Low Density Lipoprotein Receptor-Related Protein-1 genetics
MADS Domain Proteins genetics
MEF2 Transcription Factors genetics
Male genetics
Microfilament Proteins genetics
Migraine without Aura genetics
Myogenic Regulatory Factors genetics
Polymorphism, Single Nucleotide genetics
Protein-Serine-Threonine Kinases genetics
Receptors, Transforming Growth Factor beta genetics
TRPM Cation Channels genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 LRP1 protein, human
0 Low Density Lipoprotein Receptor-Related Protein-1
0 MADS Domain Proteins
0 MEF2 Transcription Factors
0 MEF2D protein, human
0 Microfilament Proteins
0 Myogenic Regulatory Factors
0 Phactr-1 protein, human
0 Receptors, Transforming Growth Factor beta
0 TRPM Cation Channels
0 TRPM8 protein, human
EC 2.7.11.1 Protein-Serine-Threonine Kinases
EC 2.7.11.30 transforming growth factor-beta type II receptor
OTHER ID's
OTHERID SOURCE
EMS54330 NLM
PMC3773912 NLM
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