Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
2267475
TITLE
Evidence for genetic influences on sleep disturbance and sleep pattern in twins.
ABSTRACT
The etiologic role of genotype and environment in sleep pattern (daytime napping, habitual bedtime, and sleep duration) and subjective sleep quality and sleep disturbance was examined using a general population sample of 3,810 adult Australian twin pairs, aged 17-88 years. Genetic differences accounted for at least 33% of the variance in sleep quality and sleep disturbance and 40% of the variance in sleep pattern. There was no evidence for a decline in the importance of genetic predisposition with age. Short-term environmental fluctuations accounted for as much as 30% of the variance, and more stable nonfamilial environmental effects accounted for the remainder. No effect of shared family environment on sleep characteristics was found.
DATE PUBLISHED
1990 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1990/08/01
medline 1990/08/01 00:01
entrez 1990/08/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Heath AC Heath A C AC Department of Human Genetics, Medical College of Virginia, Richmond.
Kendler KS Kendler K S KS
Eaves LJ Eaves L J LJ
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 13
ISSUE: 4
TITLE: Sleep
ISOABBREVIATION: Sleep
YEAR: 1990
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Sleep
COUNTRY: United States
ISSNLINKING: 0161-8105
NLMUNIQUEID: 7809084
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA06782 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
DA05588 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Anxiety Disorders psychology
Cohort Studies psychology
Diseases in Twins psychology
Female psychology
Humans psychology
Male psychology
Middle Aged psychology
Models, Genetic psychology
Risk Factors psychology
Sleep Disorders psychology
Sleep Initiation and Maintenance Disorders psychology
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's