Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22628180
TITLE
Genome-wide association uncovers shared genetic effects among personality traits and mood states.
ABSTRACT
Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (~2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546-1,338; maximum total n = 6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n = 527-6,032). Suggestive association (P = 8 × 10(-8)) of rs1079196 in the FHIT gene was observed with symptoms of anxiety. Other notable associations (P < 6.09 × 10(-6)) included SNPs in five genes for neuroticism (LCE3C, POLR3A, LMAN1L, ULK3, SCAMP2), KIAA0802 for extraversion, and NOS1 for general psychological distress. An association between symptoms of depression and rs7582472 (near to MGAT5 and NCKAP5) was replicated in two independent samples, but other replication findings were less consistent. Gene-based tests identified a significant locus on chromosome 15 (spanning five genes) associated with neuroticism which replicated (P < 0.05) in an independent cohort. Support for common genetic effects among personality and mood (particularly neuroticism and depressive symptoms) was found in terms of SNP association overlap and polygenic score prediction. The variance explained by individual SNPs was very small (up to 1%) confirming that there are no moderate/large effects of common SNPs on personality and related traits.
Copyright © 2012 Wiley Periodicals, Inc.
DATE PUBLISHED
2012 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/01/06
accepted 2012/05/03
aheadofprint 2012/05/24
entrez 2012/05/26 06:00
pubmed 2012/05/26 06:00
medline 2013/04/10 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Luciano M Luciano Michelle M Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. michelle.luciano@ed.ac.uk
Huffman JE Huffman Jennifer E JE
Arias-Vásquez A Arias-Vásquez Alejandro A
Vinkhuyzen AA Vinkhuyzen Anna A E AA
Middeldorp CM Middeldorp Christel M CM
Giegling I Giegling Ina I
Payton A Payton Antony A
Davies G Davies Gail G
Zgaga L Zgaga Lina L
Janzing J Janzing Joost J
Ke X Ke Xiayi X
Galesloot T Galesloot Tessel T
Hartmann AM Hartmann Annette M AM
Ollier W Ollier William W
Tenesa A Tenesa Albert A
Hayward C Hayward Caroline C
Verhagen M Verhagen Maaike M
Montgomery GW Montgomery Grant W GW
Hottenga JJ Hottenga Jouke-Jan JJ
Konte B Konte Bettina B
Starr JM Starr John M JM
Vitart V Vitart Veronique V
Vos PE Vos Pieter E PE
Madden PA Madden Pamela A F PA
Willemsen G Willemsen Gonneke G
Konnerth H Konnerth Heike H
Horan MA Horan Michael A MA
Porteous DJ Porteous David J DJ
Campbell H Campbell Harry H
Vermeulen SH Vermeulen Sita H SH
Heath AC Heath Andrew C AC
Wright A Wright Alan A
Polasek O Polasek Ozren O
Kovacevic SB Kovacevic Sanja B SB
Hastie ND Hastie Nicholas D ND
Franke B Franke Barbara B
Boomsma DI Boomsma Dorret I DI
Martin NG Martin Nicholas G NG
Rujescu D Rujescu Dan D
Wilson JF Wilson James F JF
Buitelaar J Buitelaar Jan J
Pendleton N Pendleton Neil N
Rudan I Rudan Igor I
Deary IJ Deary Ian J IJ
INVESTIGATORS
JOURNAL
VOLUME: 159B
ISSUE: 6
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2012
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
15/SAG09977 Biotechnology and Biological Sciences Research Council United Kingdom
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
CZB/4/505 Chief Scientist Office United Kingdom
CZB/4/710 Chief Scientist Office United Kingdom
ETM/55 Chief Scientist Office United Kingdom
G0100594 Medical Research Council United Kingdom
G0400546 Medical Research Council United Kingdom
G0700704 Medical Research Council United Kingdom
G0901461 Medical Research Council United Kingdom
G1001375 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
MC_PC_U127561128 Medical Research Council United Kingdom
P50 AA011998 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Anxiety genetics
Cohort Studies genetics
Depression genetics
Extraversion (Psychology) genetics
Female genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Humans genetics
Male genetics
Middle Aged genetics
Mood Disorders genetics
Neuropsychological Tests genetics
Neurotic Disorders genetics
Personality genetics
Polymorphism, Single Nucleotide genetics
Reproducibility of Results genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS514555 NLM
PMC3795298 NLM
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