Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22510721
TITLE
Predicting white matter integrity from multiple common genetic variants.
ABSTRACT
Several common genetic variants have recently been discovered that appear to influence white matter microstructure, as measured by diffusion tensor imaging (DTI). Each genetic variant explains only a small proportion of the variance in brain microstructure, so we set out to explore their combined effect on the white matter integrity of the corpus callosum. We measured six common candidate single-nucleotide polymorphisms (SNPs) in the COMT, NTRK1, BDNF, ErbB4, CLU, and HFE genes, and investigated their individual and aggregate effects on white matter structure in 395 healthy adult twins and siblings (age: 20-30 years). All subjects were scanned with 4-tesla 94-direction high angular resolution diffusion imaging. When combined using mixed-effects linear regression, a joint model based on five of the candidate SNPs (COMT, NTRK1, ErbB4, CLU, and HFE) explained ≈ 6% of the variance in the average fractional anisotropy (FA) of the corpus callosum. This predictive model had detectable effects on FA at 82% of the corpus callosum voxels, including the genu, body, and splenium. Predicting the brain's fiber microstructure from genotypes may ultimately help in early risk assessment, and eventually, in personalized treatment for neuropsychiatric disorders in which brain integrity and connectivity are affected.
DATE PUBLISHED
2012 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2012/04/18
entrez 2012/04/19 06:00
pubmed 2012/04/19 06:00
medline 2013/03/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kohannim O Kohannim Omid O Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-1769, USA.
Jahanshad N Jahanshad Neda N
Braskie MN Braskie Meredith N MN
Stein JL Stein Jason L JL
Chiang MC Chiang Ming-Chang MC
Reese AH Reese April H AH
Hibar DP Hibar Derrek P DP
Toga AW Toga Arthur W AW
McMahon KL McMahon Katie L KL
de Zubicaray GI de Zubicaray Greig I GI
Medland SE Medland Sarah E SE
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME: 37
ISSUE: 9
TITLE: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISOABBREVIATION: Neuropsychopharmacology
YEAR: 2012
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1740-634X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuropsychopharmacology
COUNTRY: England
ISSNLINKING: 0893-133X
NLMUNIQUEID: 8904907
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
1F31MH087061 NIMH NIH HHS United States
AG016570 NIA NIH HHS United States
EB007813 NIBIB NIH HHS United States
EB008281 NIBIB NIH HHS United States
EB008432 NIBIB NIH HHS United States
EB01651 NIBIB NIH HHS United States
F30 AG041681 NIA NIH HHS United States
LM05639 NLM NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
RR019771 NCRR NIH HHS United States
T15 LM07356 NLM NIH HHS United States
T32 GM008042 NIGMS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Cohort Studies
Corpus Callosum physiology
Diffusion Tensor Imaging methods
Female methods
Genetic Variation genetics
Humans genetics
Male genetics
Nerve Fibers, Myelinated physiology
Polymorphism, Single Nucleotide genetics
Predictive Value of Tests genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3398730 NLM