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| PMID |
|
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| TITLE |
|
| Environmental influences predominate in remission from alcohol use disorder in young adult twins. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Familial influences on remission from alcohol use disorder (AUD) have been studied using family history of AUD rather than family history of remission. The current study used a remission phenotype in a twin sample to examine the relative contributions of genetic and environmental influences to remission. |
| METHOD |
NlmCategory: METHODS |
| The sample comprised 6183 twins with an average age of 30 years from the Australian Twin Registry. Lifetime history of alcohol abuse and dependence symptoms and symptom recency were assessed with a structured telephone interview. AUD was defined broadly and narrowly as history of two or more or three or more abuse or dependence symptoms. Remission was defined as absence of symptoms at time of interview among individuals with lifetime AUD. Standard bivariate genetic analyses were conducted to derive estimates of genetic and environmental influences on AUD and remission. |
| RESULTS |
NlmCategory: RESULTS |
| Environmental influences alone accounted for remission in males and for 89% of influences on remission in females, with 11% due to genetic influences shared with AUD, which decreased the likelihood of remission. For women, more than 80% of influences on remission were distinct from influences on AUD, and environmental influences were from individual experiences only. For men, just over 50% of influences on remission were distinct from those on AUD, and the influence of environments shared with the co-twin were substantial. The results for the broad and narrow phenotypes were similar. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| The current study establishes young adult remission as a phenotype distinct from AUD and highlights the importance of environmental influences on remission. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2012/03/16 |
| entrez |
2012/03/20 06:00 |
| pubmed |
2012/03/20 06:00 |
| medline |
2012/03/20 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| McCutcheon VV |
|
McCutcheon |
V V |
VV |
|
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. |
| Grant JD |
|
Grant |
J D |
JD |
|
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. |
| Heath AC |
|
Heath |
A C |
AC |
|
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. |
| Bucholz KK |
|
Bucholz |
K K |
KK |
|
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. |
| Sartor CE |
|
Sartor |
C E |
CE |
|
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. |
| Nelson EC |
|
Nelson |
E C |
EC |
|
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. |
| Madden PA |
|
Madden |
P A F |
PA |
|
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. |
| Martin NG |
|
Martin |
N G |
NG |
|
Department of Epidemiology and Public Health, Queensland Institute for Medical Research, Brisbane, Australia. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 42 |
| ISSUE: 11 |
| TITLE: Psychological medicine |
| ISOABBREVIATION: Psychol Med |
| YEAR: 2012 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: |
| ISSNTYPE: |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Psychol Med |
| COUNTRY: England |
| ISSNLINKING: 0033-2917 |
| NLMUNIQUEID: 1254142 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
|
| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
J Stud Alcohol Suppl. 1999 Mar;13:63-74 |
10225489 |
|
| Cites |
Am J Psychiatry. 1999 Jan;156(1):34-40 |
9892295 |
|
| Cites |
Psychol Med. 2004 Nov;34(8):1519-30 |
15724882 |
|
| Cites |
Addiction. 2005 Mar;100(3):281-92 |
15733237 |
|
| Cites |
Drug Alcohol Depend. 2005 Oct 1;80(1):83-9 |
15878808 |
|
| Cites |
Addiction. 2006 Feb;101(2):212-22 |
16445550 |
|
| Cites |
J Stud Alcohol. 2006 Mar;67(2):195-203 |
16568565 |
|
| Cites |
Behav Genet. 2007 Jul;37(4):547-58 |
17453331 |
|
| Cites |
Acta Psychiatr Scand. 2007 Nov;116(5):386-93 |
17919158 |
|
| Cites |
Alcohol Clin Exp Res. 2007 Dec;31(12):2036-45 |
18034696 |
|
| Cites |
Am J Psychiatry. 2008 Sep;165(9):1172-8 |
18519526 |
|
| Cites |
Addiction. 2009 Sep;104(9):1512-8 |
19686520 |
|
| Cites |
Biol Psychiatry. 2009 Oct 15;66(8):795-800 |
19576574 |
|
| Cites |
J Subst Abuse Treat. 2010 Jan;38(1):42-50 |
19632079 |
|
| Cites |
J Stud Alcohol Drugs. 2010 Sep;71(5):685-94 |
20731973 |
|
| Cites |
Addiction. 2011 Mar;106(3):657-69 |
21077975 |
|
| Cites |
Psychol Med. 2011 Jul;41(7):1497-505 |
21054919 |
|
| Cites |
Behav Genet. 2012 Jan;42(1):40-56 |
21818662 |
|
| Cites |
Addiction. 1999 Sep;94(9):1361-70 |
10615721 |
|
| Cites |
Addiction. 1999 Jul;94(7):981-93 |
10707437 |
|
| Cites |
Behav Genet. 1999 Nov;29(6):455-61 |
10857250 |
|
| Cites |
Alcohol Clin Exp Res. 2001 May;25(5):637-43 |
11371711 |
|
| Cites |
Am J Psychiatry. 2001 Jul;158(7):1084-90 |
11431230 |
|
| Cites |
Addiction. 2001 Sep;96(9):1327-36 |
11672497 |
|
| Cites |
Alcohol Clin Exp Res. 2001 Nov;25(11):1594-604 |
11707634 |
|
| Cites |
Twin Res. 2002 Apr;5(2):113-24 |
11931689 |
|
| Cites |
JAMA. 2003 Jan 22-29;289(4):427-33 |
12533121 |
|
| Cites |
J Stud Alcohol. 2003 Nov;64(6):745-55 |
14743936 |
|
| Cites |
Am J Psychiatry. 2004 Jul;161(7):1204-10 |
15229052 |
|
| Cites |
Am J Psychiatry. 1994 May;151(5):707-15 |
8166312 |
|
| Cites |
J Stud Alcohol. 1994 Mar;55(2):149-58 |
8189735 |
|
| Cites |
J Stud Alcohol. 1994 Mar;55(2):184-202 |
8189739 |
|
| Cites |
Alcohol Clin Exp Res. 1996 Jun;20(4):771-9 |
8800398 |
|
| Cites |
Psychol Med. 1997 Nov;27(6):1381-96 |
9403910 |
|
| Cites |
Alcohol Clin Exp Res. 1999 Jul;23(7):1136-44 |
10443978 |
|
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA007535 |
NIAAA NIH HHS |
United States |
| AA017688 |
NIAAA NIH HHS |
United States |
| AA017921 |
NIAAA NIH HHS |
United States |
| AA018146 |
NIAAA NIH HHS |
United States |
| AA12640 |
NIAAA NIH HHS |
United States |
| DA14363 |
NIDA NIH HHS |
United States |
| K01 AA018146 |
NIAAA NIH HHS |
United States |
| K01 AA018146-03 |
NIAAA NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| K08 AA017921 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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| OTHERID |
SOURCE |
| NIHMS365558 |
NLM |
| PMC3752317 |
NLM |
|
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