Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22423619
TITLE
Environmental influences predominate in remission from alcohol use disorder in young adult twins.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Familial influences on remission from alcohol use disorder (AUD) have been studied using family history of AUD rather than family history of remission. The current study used a remission phenotype in a twin sample to examine the relative contributions of genetic and environmental influences to remission.
METHOD NlmCategory: METHODS
The sample comprised 6183 twins with an average age of 30 years from the Australian Twin Registry. Lifetime history of alcohol abuse and dependence symptoms and symptom recency were assessed with a structured telephone interview. AUD was defined broadly and narrowly as history of two or more or three or more abuse or dependence symptoms. Remission was defined as absence of symptoms at time of interview among individuals with lifetime AUD. Standard bivariate genetic analyses were conducted to derive estimates of genetic and environmental influences on AUD and remission.
RESULTS NlmCategory: RESULTS
Environmental influences alone accounted for remission in males and for 89% of influences on remission in females, with 11% due to genetic influences shared with AUD, which decreased the likelihood of remission. For women, more than 80% of influences on remission were distinct from influences on AUD, and environmental influences were from individual experiences only. For men, just over 50% of influences on remission were distinct from those on AUD, and the influence of environments shared with the co-twin were substantial. The results for the broad and narrow phenotypes were similar.
CONCLUSIONS NlmCategory: CONCLUSIONS
The current study establishes young adult remission as a phenotype distinct from AUD and highlights the importance of environmental influences on remission.
DATE PUBLISHED
2012 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2012/03/16
entrez 2012/03/20 06:00
pubmed 2012/03/20 06:00
medline 2012/03/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
McCutcheon VV McCutcheon V V VV Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Grant JD Grant J D JD Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Heath AC Heath A C AC Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Bucholz KK Bucholz K K KK Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Sartor CE Sartor C E CE Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Nelson EC Nelson E C EC Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Madden PA Madden P A F PA Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Martin NG Martin N G NG Department of Epidemiology and Public Health, Queensland Institute for Medical Research, Brisbane, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 42
ISSUE: 11
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2012
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA007535 NIAAA NIH HHS United States
AA017688 NIAAA NIH HHS United States
AA017921 NIAAA NIH HHS United States
AA018146 NIAAA NIH HHS United States
AA12640 NIAAA NIH HHS United States
DA14363 NIDA NIH HHS United States
K01 AA018146 NIAAA NIH HHS United States
K01 AA018146-03 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
K08 AA017921 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS365558 NLM
PMC3752317 NLM