Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
22393221
TITLE
Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression.
ABSTRACT
CONTEXT NlmCategory: BACKGROUND
Understanding the relative contributions of genetic and environmental factors to trauma exposure, posttraumatic stress disorder (PTSD), and major depressive disorder (MDD) is critical to developing etiologic models of these conditions and their co-occurrence.
OBJECTIVES NlmCategory: OBJECTIVE
To quantify heritable influences on low-risk trauma, high-risk trauma, PTSD, and MDD and to estimate the degree of overlap between genetic and environmental sources of variance in these 4 phenotypes.
DESIGN NlmCategory: METHODS
Adult twins and their siblings were ascertained from a large population-based sample of female and male twin pairs on the basis of screening items for childhood sexual abuse and physical abuse obtained in a previous assessment of this cohort.
SETTING NlmCategory: METHODS
Structured psychiatric telephone interviews.
PARTICIPANTS NlmCategory: METHODS
Total sample size of 2591: 996 female and 536 male twins; 625 female and 434 male nontwin siblings.
MAIN OUTCOME MEASURE NlmCategory: METHODS
Lifetime low- and high-risk trauma exposure, PTSD, and MDD.
RESULTS NlmCategory: RESULTS
In the best-fitting genetic model, 47% of the variance in low-risk trauma exposure and 60% of the variance in high-risk trauma exposure was attributable to additive genetic factors. Heritable influences accounted for 46% of the variance in PTSD and 27% of the variance in MDD. An extremely high degree of genetic overlap was observed between high-risk trauma exposure and both PTSD (r = 0.89; 95% CI, 0.78-0.99) and MDD (r = 0.89; 95% CI, 0.77-0.98). Complete correlation of genetic factors contributing to PTSD and to MDD (r = 1.00) was observed.
CONCLUSIONS NlmCategory: CONCLUSIONS
The evidence suggests that almost all the heritable influences on high-risk trauma exposure, PTSD, and MDD, can be traced to the same sources; that is, genetic risk is not disorder specific. Individuals with a positive family history of either PTSD or MDD are at elevated risk for both disorders and should be closely monitored after a traumatic experience for symptoms of PTSD and MDD.
DATE PUBLISHED
2012 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/03/07 06:00
pubmed 2012/03/07 06:00
medline 2012/04/26 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Sartor CE Sartor Carolyn E CE Department of Psychiatry, Yale School of Medicine, VA Connecticut Healthcare System, USA. carolyn.sartor@yale.edu
Grant JD Grant Julia D JD
Lynskey MT Lynskey Michael T MT
McCutcheon VV McCutcheon Vivia V VV
Waldron M Waldron Mary M
Statham DJ Statham Dixie J DJ
Bucholz KK Bucholz Kathleen K KK
Madden PA Madden Pamela A F PA
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
Nelson EC Nelson Elliot C EC
INVESTIGATORS
JOURNAL
VOLUME: 69
ISSUE: 3
TITLE: Archives of general psychiatry
ISOABBREVIATION: Arch. Gen. Psychiatry
YEAR: 2012
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Arch Gen Psychiatry
COUNTRY: United States
ISSNLINKING: 0003-990X
NLMUNIQUEID: 0372435
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Am J Hum Genet. 2007 May;80(5):856-66 17436240
Cites Eur Arch Psychiatry Clin Neurosci. 2006 Aug;256(5):299-306 16783498
Cites J Affect Disord. 2008 Jan;105(1-3):109-15 17540456
Cites Arch Gen Psychiatry. 2008 Jun;65(6):713-21 18519829
Cites J Consult Clin Psychol. 2008 Aug;76(4):633-47 18665691
Cites J Urban Health. 2008 Sep;85(5):693-706 18581238
Cites Psychol Med. 2009 Mar;39(3):431-41 18533058
Cites Trauma Violence Abuse. 2009 Jul;10(3):198-210 19406860
Cites Br J Psychiatry. 2009 Oct;195(4):301-7 19794197
Cites Twin Res Hum Genet. 2010 Apr;13(2):121-30 20397742
Cites J Abnorm Psychol. 2010 May;119(2):320-30 20455605
Cites J Stud Alcohol Drugs. 2010 Nov;71(6):810-8 20946737
Cites Psychol Med. 2011 Jul;41(7):1497-505 21054919
Cites Addiction. 1999 Sep;94(9):1361-70 10615721
Cites Drug Alcohol Depend. 2000 Dec 22;61(1):95-102 11064187
Cites Biol Psychiatry. 2000 Nov 1;48(9):902-9 11074228
Cites Twin Res. 2001 Apr;4(2):73-80 11665339
Cites Psychol Med. 2001 Oct;31(7):1237-47 11681550
Cites Arch Gen Psychiatry. 2002 Feb;59(2):139-45 11825135
Cites Twin Res. 2002 Apr;5(2):113-24 11931689
Cites Am J Psychiatry. 2002 Jul;159(7):1133-45 12091191
Cites Am J Psychiatry. 2002 Oct;159(10):1675-81 12359672
Cites Psychiatry Res. 2003 Aug 30;120(1):61-9 14500115
Cites Behav Res Ther. 2004 Jan;42(1):105-14 14744527
Cites Br J Psychiatry. 2004 Jun;184:482-7 15172941
Cites J Consult Clin Psychol. 1988 Dec;56(6):843-50 3264558
Cites Arch Gen Psychiatry. 1991 Mar;48(3):216-22 1996917
Cites Arch Gen Psychiatry. 1993 Apr;50(4):257-64 8466386
Cites Am J Med Genet. 1993 May 1;48(1):22-7 8357033
Cites J Consult Clin Psychol. 1993 Dec;61(6):984-91 8113499
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites BMJ. 1995 Feb 18;310(6977):432-6 7873948
Cites J Child Psychol Psychiatry. 1995 Mar;36(3):449-58 7782408
Cites Arch Gen Psychiatry. 1995 Dec;52(12):1048-60 7492257
Cites J Nerv Ment Dis. 1996 May;184(5):307-13 8627277
Cites J Am Acad Child Adolesc Psychiatry. 1996 Oct;35(10):1365-74 8885591
Cites Arch Gen Psychiatry. 1997 Nov;54(11):1044-8 9366662
Cites Pharmacopsychiatry. 1998 Jan;31(1):5-9 9524977
Cites Arch Gen Psychiatry. 1998 May;55(5):468-72 9596050
Cites Arch Gen Psychiatry. 1998 Jul;55(7):626-32 9672053
Cites J Trauma Stress. 2005 Feb;18(1):23-32 16281192
Cites Am J Psychiatry. 2006 Jan;163(1):115-24 16390898
Cites Psychol Med. 2006 Mar;36(3):387-95 16255836
Cites Biol Psychiatry. 2007 Nov 15;62(10):1088-94 17617384
GRANTS
GRANTID AGENCY COUNTRY
AA011998 NIAAA NIH HHS United States
AA011998_5978 NIAAA NIH HHS United States
AA013446 NIAAA NIH HHS United States
AA017921 NIAAA NIH HHS United States
AA018146 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA12640 NIAAA NIH HHS United States
DA012854 NIDA NIH HHS United States
DA023696 NIDA NIH HHS United States
DA14363 NIDA NIH HHS United States
K01 AA018146 NIAAA NIH HHS United States
K01 AA018146-03 NIAAA NIH HHS United States
K01 DA023696 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
K08 AA017921 NIAAA NIH HHS United States
P60 AA011998 NIAAA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
R01 AA012640 NIAAA NIH HHS United States
R01 AA013446 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA014363 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Adult Survivors of Child Abuse statistics & numerical data
Child statistics & numerical data
Child Abuse psychology
Child Abuse, Sexual psychology
Comorbidity psychology
Depressive Disorder, Major genetics
Female genetics
Genetic Predisposition to Disease genetics
Humans genetics
Interview, Psychological genetics
Male genetics
Prevalence genetics
Sex Factors genetics
Stress Disorders, Post-Traumatic genetics
Twins psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS365557 NLM
PMC3594801 NLM
Designed by: GenEpi IT
Maintained by: GenEpi IT
Feedback: webmaster
Copyright © 2007 QIMR
For more information Contact Us
epiit@qimr.edu.au
Last Modified: Oct 15 2007