Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22393221
TITLE
Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression.
ABSTRACT
CONTEXT NlmCategory: BACKGROUND
Understanding the relative contributions of genetic and environmental factors to trauma exposure, posttraumatic stress disorder (PTSD), and major depressive disorder (MDD) is critical to developing etiologic models of these conditions and their co-occurrence.
OBJECTIVES NlmCategory: OBJECTIVE
To quantify heritable influences on low-risk trauma, high-risk trauma, PTSD, and MDD and to estimate the degree of overlap between genetic and environmental sources of variance in these 4 phenotypes.
DESIGN NlmCategory: METHODS
Adult twins and their siblings were ascertained from a large population-based sample of female and male twin pairs on the basis of screening items for childhood sexual abuse and physical abuse obtained in a previous assessment of this cohort.
SETTING NlmCategory: METHODS
Structured psychiatric telephone interviews.
PARTICIPANTS NlmCategory: METHODS
Total sample size of 2591: 996 female and 536 male twins; 625 female and 434 male nontwin siblings.
MAIN OUTCOME MEASURE NlmCategory: METHODS
Lifetime low- and high-risk trauma exposure, PTSD, and MDD.
RESULTS NlmCategory: RESULTS
In the best-fitting genetic model, 47% of the variance in low-risk trauma exposure and 60% of the variance in high-risk trauma exposure was attributable to additive genetic factors. Heritable influences accounted for 46% of the variance in PTSD and 27% of the variance in MDD. An extremely high degree of genetic overlap was observed between high-risk trauma exposure and both PTSD (r = 0.89; 95% CI, 0.78-0.99) and MDD (r = 0.89; 95% CI, 0.77-0.98). Complete correlation of genetic factors contributing to PTSD and to MDD (r = 1.00) was observed.
CONCLUSIONS NlmCategory: CONCLUSIONS
The evidence suggests that almost all the heritable influences on high-risk trauma exposure, PTSD, and MDD, can be traced to the same sources; that is, genetic risk is not disorder specific. Individuals with a positive family history of either PTSD or MDD are at elevated risk for both disorders and should be closely monitored after a traumatic experience for symptoms of PTSD and MDD.
DATE PUBLISHED
2012 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/03/07 06:00
pubmed 2012/03/07 06:00
medline 2012/04/26 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Sartor CE Sartor Carolyn E CE Department of Psychiatry, Yale School of Medicine, VA Connecticut Healthcare System, USA. carolyn.sartor@yale.edu
Grant JD Grant Julia D JD
Lynskey MT Lynskey Michael T MT
McCutcheon VV McCutcheon Vivia V VV
Waldron M Waldron Mary M
Statham DJ Statham Dixie J DJ
Bucholz KK Bucholz Kathleen K KK
Madden PA Madden Pamela A F PA
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
Nelson EC Nelson Elliot C EC
INVESTIGATORS
JOURNAL
VOLUME: 69
ISSUE: 3
TITLE: Archives of general psychiatry
ISOABBREVIATION: Arch. Gen. Psychiatry
YEAR: 2012
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Arch Gen Psychiatry
COUNTRY: United States
ISSNLINKING: 0003-990X
NLMUNIQUEID: 0372435
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA011998 NIAAA NIH HHS United States
AA011998_5978 NIAAA NIH HHS United States
AA013446 NIAAA NIH HHS United States
AA017921 NIAAA NIH HHS United States
AA018146 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA12640 NIAAA NIH HHS United States
DA012854 NIDA NIH HHS United States
DA023696 NIDA NIH HHS United States
DA14363 NIDA NIH HHS United States
K01 AA018146 NIAAA NIH HHS United States
K01 AA018146-03 NIAAA NIH HHS United States
K01 DA023696 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
K08 AA017921 NIAAA NIH HHS United States
P60 AA011998 NIAAA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
R01 AA012640 NIAAA NIH HHS United States
R01 AA013446 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA014363 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Adult Survivors of Child Abuse statistics & numerical data
Child statistics & numerical data
Child Abuse psychology
Child Abuse, Sexual psychology
Comorbidity psychology
Depressive Disorder, Major genetics
Female genetics
Genetic Predisposition to Disease genetics
Humans genetics
Interview, Psychological genetics
Male genetics
Prevalence genetics
Sex Factors genetics
Stress Disorders, Post-Traumatic genetics
Twins psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS365557 NLM
PMC3594801 NLM