Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
22362865
TITLE
A genome-wide study on the perception of the odorants androstenone and galaxolide.
ABSTRACT
Twin pairs and their siblings rated the intensity of the odorants amyl acetate, androstenone, eugenol, Galaxolide, mercaptans, and rose (N = 1573). Heritability was established for ratings of androstenone (h (2) = 0.30) and Galaxolide (h(2) = 0.34) but not for the other odorants. Genome-wide association analysis using 2.3 million single nucleotide polymorphisms indicated that the most significant association was between androstenone and a region without known olfactory receptor genes (rs10966900, P = 1.2 ? 10(-7)). A previously reported association between the olfactory receptor OR7D4 and the androstenone was not detected until we specifically typed this gene (P = 1.1 ? 10(-4)). We also tested these 2 associations in a second independent sample of subjects and replicated the results either fully (OR7D4, P = 0.00002) or partially (rs10966900, P = 0.010; N = 266). These findings suggest that 1) the perceived intensity of some but not all odorants is a heritable trait, 2) use of a current genome-wide marker panel did not detect a known olfactory genotype-phenotype association, and 3) person-to-person differences in androstenone perception are influenced by OR7D4 genotype and perhaps by variants of other genes.
DATE PUBLISHED
2012 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2012/02/23
entrez 2012/02/25 06:00
pubmed 2012/03/01 06:00
medline 2013/06/12 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Knaapila A Knaapila Antti A Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA.
Zhu G Zhu Gu G
Medland SE Medland Sarah E SE
Wysocki CJ Wysocki Charles J CJ
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Reed DR Reed Danielle R DR
INVESTIGATORS
JOURNAL
VOLUME: 37
ISSUE: 6
TITLE: Chemical senses
ISOABBREVIATION: Chem. Senses
YEAR: 2012
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Chem Senses
COUNTRY: England
ISSNLINKING: 0379-864X
NLMUNIQUEID: 8217190
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites J Comp Physiol A. 1999 Oct;185(4):297-304 10555266
Cites Chem Senses. 2011 Jan;36(1):9-17 20876394
Cites Oncogene. 2004 Aug 26;23(39):6612-20 15208665
Cites Nature. 1967 Jun 10;214(5093):1095-8 4861233
Cites J Sci Food Agric. 1970 Jan;21(1):4-6 5418189
Cites Nature. 1973 Mar 23;242(5395):271-3 4696259
Cites Science. 1980 May 9;208(4444):607-9 7189296
Cites Acta Med Acad Sci Hung. 1981;38(2):153-8 7198858
Cites Immunogenetics. 1982;15(6):579-89 7201974
Cites Proc Natl Acad Sci U S A. 1984 Aug;81(15):4899-902 6589634
Cites Ann N Y Acad Sci. 1989;561:12-28 2735671
Cites Proc Natl Acad Sci U S A. 1989 Oct;86(20):7976-8 2813372
Cites Neurosci Lett. 1992 Jul 6;141(1):115-8 1508392
Cites Chem Senses. 1994 Jun;19(3):197-208 8055270
Cites Chem Senses. 1996 Aug;21(4):411-6 8866105
Cites Cell. 1998 Dec 23;95(7):917-26 9875846
Cites Cell. 1999 Mar 5;96(5):713-23 10089886
Cites Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9885-90 10449789
Cites Pediatrics. 2005 Feb;115(2):e216-22 15687429
Cites Chem Senses. 2006 Jun;31(5):403-13 16527870
Cites Chem Senses. 2007 Jan;32(1):21-30 17008420
Cites Am J Hum Genet. 2007 Mar;80(3):531-8 17273975
Cites Nature. 2007 Sep 27;449(7161):468-72 17873857
Cites Am J Hum Genet. 2007 Nov;81(5):913-26 17924335
Cites PLoS Biol. 2007 Oct 30;5(11):e284 17973576
Cites Physiol Genomics. 2008 Jan 17;32(2):198-206 17971504
Cites Chem Senses. 2008 Feb;33(2):145-62 18032372
Cites Chem Biodivers. 2008 Jun;5(6):862-86 18618409
Cites Behav Genet. 2008 Sep;38(5):484-92 18543092
Cites PLoS Genet. 2008 Nov;4(11):e1000249 18989455
Cites Proteomics. 2009 Jan;9(2):322-34 19086097
Cites Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11776-81 19561302
Cites Am J Hum Genet. 2009 Nov;85(5):750-5 19896111
Cites ASN Neuro. 2010;2(1):e00028 20309390
Cites PLoS Genet. 2010 Jun;6(6):e1000993 20585627
Cites N Engl J Med. 2010 Jul 8;363(2):166-76 20647212
Cites Nature. 2003 Dec 18;426(6968):789-96 14685227
GRANTS
GRANTID AGENCY COUNTRY
P30DC0011735 NIDCD NIH HHS United States
R01 DC004698 NIDCD NIH HHS United States
R03 DC003509 NIDCD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Androsterone pharmacology
Benzopyrans pharmacology
Child pharmacology
Female pharmacology
Genome-Wide Association Study pharmacology
Genotype pharmacology
Humans pharmacology
Male pharmacology
Odors analysis
Polymorphism, Genetic genetics
Receptors, Odorant metabolism
Siblings metabolism
Smell physiology
Stimulation, Chemical physiology
Young Adult physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Benzopyrans
0 Receptors, Odorant
14170060AT galaxolide
C24W7J5D5R Androsterone
OTHER ID's
OTHERID SOURCE
PMC3452230 NLM