Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22347368
TITLE
Genetic and environmental contributions to weight, height, and BMI from birth to 19 years of age: an international study of over 12,000 twin pairs.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
To examine the genetic and environmental influences on variances in weight, height, and BMI, from birth through 19 years of age, in boys and girls from three continents.
DESIGN AND SETTINGS NlmCategory: METHODS
Cross-sectional twin study. Data obtained from a total of 23 twin birth-cohorts from four countries: Canada, Sweden, Denmark, and Australia. Participants were Monozygotic (MZ) and dizygotic (DZ) (same- and opposite-sex) twin pairs with data available for both height and weight at a given age, from birth through 19 years of age. Approximately 24,036 children were included in the analyses.
RESULTS NlmCategory: RESULTS
Heritability for body weight, height, and BMI was low at birth (between 6.4 and 8.7% for boys, and between 4.8 and 7.9% for girls) but increased over time, accounting for close to half or more of the variance in body weight and BMI after 5 months of age in both sexes. Common environmental influences on all body measures were high at birth (between 74.1-85.9% in all measures for boys, and between 74.2 and 87.3% in all measures for girls) and markedly reduced over time. For body height, the effect of the common environment remained significant for a longer period during early childhood (up through 12 years of age). Sex-limitation of genetic and shared environmental effects was observed.
CONCLUSION NlmCategory: CONCLUSIONS
Genetics appear to play an increasingly important role in explaining the variation in weight, height, and BMI from early childhood to late adolescence, particularly in boys. Common environmental factors exert their strongest and most independent influence specifically in pre-adolescent years and more significantly in girls. These findings emphasize the need to target family and social environmental interventions in early childhood years, especially for females. As gene-environment correlation and interaction is likely, it is also necessary to identify the genetic variants that may predispose individuals to obesity.
DATE PUBLISHED
2012
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/07/26
accepted 2011/12/11
epublish 2012/02/08
entrez 2012/02/21 06:00
pubmed 2012/02/22 06:00
medline 2012/08/01 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Dubois L Dubois Lise L Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada. lise.dubois@uottawa.ca
Ohm Kyvik K Ohm Kyvik Kirsten K
Girard M Girard Manon M
Tatone-Tokuda F Tatone-Tokuda Fabiola F
Pérusse D Pérusse Daniel D
Hjelmborg J Hjelmborg Jacob J
Skytthe A Skytthe Axel A
Rasmussen F Rasmussen Finn F
Wright MJ Wright Margaret J MJ
Lichtenstein P Lichtenstein Paul P
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 7
ISSUE: 2
TITLE: PloS one
ISOABBREVIATION: PLoS ONE
YEAR: 2012
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1932-6203
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: PLoS One
COUNTRY: United States
ISSNLINKING: 1932-6203
NLMUNIQUEID: 101285081
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Australia
Body Height
Body Mass Index
Body Weight
Canada
Child
Child, Preschool
Cross-Sectional Studies
Denmark
Female
Gene-Environment Interaction
Humans
Infant
Infant, Newborn
Male
Sweden
Twins
Young Adult
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3275599 NLM