Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22307698
TITLE
Estimating heritability from twin studies.
ABSTRACT
This chapter describes how the heritability of a trait can be estimated using data collected from pairs of twins. The principles of the classical twin design are described, followed by the assumptions and possible extensions of the design. In the second part of this chapter, two example scripts are presented and described, explaining the basic steps for estimating heritability using the statistical program OpenMx. OpenMx and the scripts used for this chapter can be downloaded so that readers can adapt and use the scripts for their own purposes.
DATE PUBLISHED
2012
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/02/07 06:00
pubmed 2012/02/07 06:00
medline 2012/05/12 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Verweij KJ Verweij Karin J H KJ Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, QLD, Australia.
Mosing MA Mosing Miriam A MA
Zietsch BP Zietsch Brendan P BP
Medland SE Medland Sarah E SE
INVESTIGATORS
JOURNAL
VOLUME: 850
ISSUE:
TITLE: Methods in molecular biology (Clifton, N.J.)
ISOABBREVIATION: Methods Mol Biol
YEAR: 2012
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1940-6029
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Methods Mol Biol
COUNTRY: United States
ISSNLINKING: 1064-3745
NLMUNIQUEID: 9214969
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Female
Humans
Male
Models, Genetic
Twin Studies as Topic
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's