Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22302529
TITLE
Genetic influences on four measures of executive functions and their covariation with general cognitive ability: the Older Australian Twins Study.
ABSTRACT
"Executive functions" (EF) is a multidimensional construct which encompasses many higher-order cognitive control operations, and is considered a potential mediator of age-associated changes in other cognitive domains. Here we examine the heritability of four measures of EF, and the genetic influences on their covariation with general cognitive abilities (GCA) from the Older Australian Twins Study. Participants included 117 pairs of monozygotic twins, 98 pairs of dizygotic twins, and 42 single twins, with a mean age of 71. Genetic modeling showed that additive genetic factors contributed to 59, 63,29, and 31% of the variance in the four measures: working memory, verbal fluency, response inhibition and cognitive flexibility, respectively. The phenotypic associations among the four EF measures were modest, which is in line with other evidence that EF is a multi-dimensional construct.All of the covariation between the EF measures was attributable to a common genetic factor. Similarly, all of the covariation between EF and General Cognitive Ability was explained by a common genetic factor, with no significant covariance due to environmental (E) factors. The genetic correlations between the measures were moderately high, suggesting that they may have common biological underpinnings. The genetic influence in the covariation of the EF measures and GCA also suggests that some aspects of EF and GCA share the same genes or same set of genes.
DATE PUBLISHED
2012 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/08/22
accepted 2012/01/16
aheadofprint 2012/02/03
entrez 2012/02/04 06:00
pubmed 2012/02/04 06:00
medline 2012/11/02 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lee T Lee Teresa T Brain and Aging Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia. teresa.lee@unsw.edu.au
Mosing MA Mosing Miriam A MA
Henry JD Henry Julie D JD
Trollor JN Trollor Julian N JN
Ames D Ames David D
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Sachdev PS Sachdev Perminder S PS
OATS Research Team
INVESTIGATORS
JOURNAL
VOLUME: 42
ISSUE: 4
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2012
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
ErratumIn Behav Genet. 2012 Jul;42(4):539-40
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Aged
Aged, 80 and over
Aging genetics
Cognition genetics
Executive Function genetics
Female genetics
Humans genetics
Inhibition (Psychology) genetics
Male genetics
Memory, Short-Term genetics
Models, Genetic genetics
Phenotype genetics
Stroop Test genetics
Trail Making Test genetics
Twins, Dizygotic psychology
Twins, Monozygotic psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's