Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22233245
TITLE
Coaction of stress and serotonin transporter genotype in predicting aggression at the transition to adulthood.
ABSTRACT
Despite consistent evidence that serotonin functioning affects stress reactivity and vulnerability to aggression, research on serotonin gene-stress interactions (G ? E) in the development of aggression remains limited. The present study investigated variation in the promoter region of the serotonin transporter gene (5-HTTLPR) as a moderator of the stress-aggression association at the transition to adulthood. Multiple informants and multiple measures were used to assess aggression in a cohort of 381 Australian youth (61% female, 93% Caucasian) interviewed at ages 15 and 20. At age 20, semistructured interviews assessed acute and chronic stressors occurring in the past 12 months. Structural equation modeling analyses revealed a significant main effect of chronic stress, but not 5-HTTLPR or acute stress, on increases in aggression at age 20. Consistent with G ? E hypotheses, 5-HTTLPR short allele carriers demonstrated greater increments in aggression following chronic stress relative to long allele homozygotes. The strength of chronic stress G ? E did not vary according to sex. Variation at 5-HTTLPR appears to contribute to individual differences in aggressive reactions to chronic stress at the transition to adulthood.
DATE PUBLISHED
2012
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/01/12 06:00
pubmed 2012/01/12 06:00
medline 2012/05/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Conway CC Conway Christopher C CC Department of Psychology, University of California, Los Angeles, CA 90095, USA. conwayc@ucla.edu
Keenan-Miller D Keenan-Miller Danielle D
Hammen C Hammen Constance C
Lind PA Lind Penelope A PA
Najman JM Najman Jake M JM
Brennan PA Brennan Patricia A PA
INVESTIGATORS
JOURNAL
VOLUME: 41
ISSUE: 1
TITLE: Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
ISOABBREVIATION: J Clin Child Adolesc Psychol
YEAR: 2012
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: J Clin Child Adolesc Psychol
COUNTRY: England
ISSNLINKING: 1537-4416
NLMUNIQUEID: 101133858
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 MH052239 NIMH NIH HHS United States
R01 MH052239-10 NIMH NIH HHS United States
R01 MH52239 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Aggression psychology
Alleles psychology
Female psychology
Genotype psychology
Humans psychology
Interview, Psychological psychology
Male psychology
Polymorphism, Genetic psychology
Serotonin Plasma Membrane Transport Proteins genetics
Stress, Psychological psychology
Young Adult psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Serotonin Plasma Membrane Transport Proteins
OTHER ID's
OTHERID SOURCE
NIHMS358656 NLM
PMC3306815 NLM