Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22213687
TITLE
Longevity candidate genes and their association with personality traits in the elderly.
ABSTRACT
Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P < 0.0002), but there was an over-representation of nominally significant (P < 0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17,106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged >60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.
Copyright © 2011 Wiley Periodicals, Inc.
DATE PUBLISHED
2012 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/06/21
accepted 2011/12/05
aheadofprint 2011/12/27
entrez 2012/01/04 06:00
pubmed 2012/01/04 06:00
medline 2012/05/23 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Luciano M Luciano Michelle M Centre for Cognitive Aging and Cognitive Epidemiology, The University of Edinburgh, UK. michelle.luciano@ed.ac.uk
Lopez LM Lopez Lorna M LM
de Moor MH de Moor Marleen H M MH
Harris SE Harris Sarah E SE
Davies G Davies Gail G
Nutile T Nutile Teresa T
Krueger RF Krueger Robert F RF
Esko T Esko Tõnu T
Schlessinger D Schlessinger David D
Toshiko T Toshiko Tanaka T
Derringer JL Derringer Jaime L JL
Realo A Realo Anu A
Hansell NK Hansell Narelle K NK
Pergadia ML Pergadia Michele L ML
Pesonen AK Pesonen Anu-Katriina AK
Sanna S Sanna Serena S
Terracciano A Terracciano Antonio A
Madden PA Madden Pamela A F PA
Penninx B Penninx Brenda B
Spinhoven P Spinhoven Philip P
Hartman CA Hartman Catherina A CA
Oostra BA Oostra Ben A BA
Janssens AC Janssens A Cecile J W AC
Eriksson JG Eriksson Johan G JG
Starr JM Starr John M JM
Cannas A Cannas Alessandra A
Ferrucci L Ferrucci Luigi L
Metspalu A Metspalu Andres A
Wright MJ Wright Margeret J MJ
Heath AC Heath Andrew C AC
van Duijn CM van Duijn Cornelia M CM
Bierut LJ Bierut Laura J LJ
Raikkonen K Raikkonen Katri K
Martin NG Martin Nicholas G NG
Ciullo M Ciullo Marina M
Rujescu D Rujescu Dan D
Boomsma DI Boomsma Dorret I DI
Deary IJ Deary Ian J IJ
INVESTIGATORS
JOURNAL
VOLUME: 159B
ISSUE: 2
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2012
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
G0700704 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
P01 CA089392 NCI NIH HHS United States
P01 CA089392-09 NCI NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA013423 NIDA NIH HHS United States
R01 DA013423-05 NIDA NIH HHS United States
R01 DA019963 NIDA NIH HHS United States
R01 DA019963-03 NIDA NIH HHS United States
U01 HG004422 NHGRI NIH HHS United States
U01 HG004422-02 NHGRI NIH HHS United States
ZIA AG000180-25 Intramural NIH HHS United States
ZIA AG000180-26 Intramural NIH HHS United States
ZIA AG000183-22 Intramural NIH HHS United States
ZIA AG000183-23 Intramural NIH HHS United States
ZIA AG000196-03 Intramural NIH HHS United States
ZIA AG000196-04 Intramural NIH HHS United States
Biotechnology and Biological Sciences Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Anxiety Disorders genetics
Cohort Studies genetics
Depression genetics
Female genetics
Genetic Markers genetics
Genotype genetics
Haplotypes genetics
Humans genetics
Longevity genetics
Male genetics
Middle Aged genetics
Personality Disorders psychology
Personality Tests psychology
Phenotype psychology
Phosphoric Monoester Hydrolases genetics
Polymerase Chain Reaction genetics
Polymorphism, Single Nucleotide genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
EC 3.1.3.- Phosphoric Monoester Hydrolases
EC 3.1.3.36 phosphoinositide 5-phosphatase
OTHER ID's
OTHERID SOURCE
NIHMS348228 NLM
PMC3583011 NLM
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