Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22032766
TITLE
Cognitive functioning in older twins: the Older Australian Twins Study.
ABSTRACT
AIM NlmCategory: OBJECTIVE
To examine the concordance rates of common medical conditions and neurocognitive performance in monozygotic (MZ) and dizygotic (DZ) older twins.
METHODS NlmCategory: METHODS
Twins aged ≥ 65 years and living in the three Eastern states of Australia were recruited through the Australian Twin Registry and underwent detailed neuropsychological and medical assessment.
RESULTS NlmCategory: RESULTS
Assessments were conducted on 113 MZ and 96 DZ twin pairs, with a mean age of 70.5 years. MZ twins were more concordant than DZ twins for hypertension and asthma. MZ twins had higher correlations than DZ twins on most neuropsychological tests, with the exception of some tests related to processing speed. The concordance rate for mild cognitive impairment or dementia was 76.2% in MZ twins and 42.9% in DZ twins, a non-significant difference.
CONCLUSIONS NlmCategory: CONCLUSIONS
Except for some aspects of processing speed, most cognitive functions in older individuals show significant heritability. The heritability of neurocognitive disorders is, however, low.
2011 The Authors. Australasian Journal on Ageing 2011 ACOTA.
DATE PUBLISHED
2011 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2011/10/29 06:00
pubmed 2011/12/07 06:00
medline 2012/02/10 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Sachdev PS Sachdev Perminder S PS Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, New South Wales, Australia. p.sachdev@unsw.edu.au
Lee T Lee Teresa T
Lammel A Lammel Andrea A
Crawford J Crawford John J
Trollor JN Trollor Julian N JN
Wright MJ Wright Margaret J MJ
Brodaty H Brodaty Henry H
Ames D Ames David D
Martin NG Martin Nicholas G NG
OATS research team
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Arasaratnam Caroline C
Azar Pamela P
Halliday Glenda G
Harding Antony A
Kumfor Fiona F
Lux Ora O
Menant Jasmine J
Nichles Alissa A
Schofield Peter P
Walker Alison A
Wong Alfred A
Zhang Jacqueline J
Beeby Harry H
Eldrdge Ann A
Garden Natalie N
Grace Marlene M
Henders Anjali A
McMahon Katie K
Park Daniel D
Redfern Claire C
Tovanen Amanda A
de Zubicaray Greig G
Delmar Gihan G
Lemmon Christel C
Mangelsdorf Simone S
Cortes Nicholas N
Walker Stacey S
JOURNAL
VOLUME: 30 Suppl 2
ISSUE:
TITLE: Australasian journal on ageing
ISOABBREVIATION: Australas J Ageing
YEAR: 2011
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1741-6612
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Australas J Ageing
COUNTRY: Australia
ISSNLINKING: 1440-6381
NLMUNIQUEID: 9808874
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Aged
Australia
Cognition
Dementia genetics
Female genetics
Humans genetics
Male genetics
Mild Cognitive Impairment genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's