Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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22001757
TITLE
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
ABSTRACT
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10(-8) to P = 10(-190)). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.
DATE PUBLISHED
2011 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/03/08
accepted 2011/09/12
aheadofprint 2011/10/16
entrez 2011/10/18 06:00
pubmed 2011/10/18 06:00
medline 2011/12/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Chambers JC Chambers John C JC Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK. john.chambers@ic.ac.uk
Zhang W Zhang Weihua W
Sehmi J Sehmi Joban J
Li X Li Xinzhong X
Wass MN Wass Mark N MN
Van der Harst P Van der Harst Pim P
Holm H Holm Hilma H
Sanna S Sanna Serena S
Kavousi M Kavousi Maryam M
Baumeister SE Baumeister Sebastian E SE
Coin LJ Coin Lachlan J LJ
Deng G Deng Guohong G
Gieger C Gieger Christian C
Heard-Costa NL Heard-Costa Nancy L NL
Hottenga JJ Hottenga Jouke-Jan JJ
Kühnel B Kühnel Brigitte B
Kumar V Kumar Vinod V
Lagou V Lagou Vasiliki V
Liang L Liang Liming L
Luan J Luan Jian'an J
Vidal PM Vidal Pedro Marques PM
Mateo Leach I Mateo Leach Irene I
O'Reilly PF O'Reilly Paul F PF
Peden JF Peden John F JF
Rahmioglu N Rahmioglu Nilufer N
Soininen P Soininen Pasi P
Speliotes EK Speliotes Elizabeth K EK
Yuan X Yuan Xin X
Thorleifsson G Thorleifsson Gudmar G
Alizadeh BZ Alizadeh Behrooz Z BZ
Atwood LD Atwood Larry D LD
Borecki IB Borecki Ingrid B IB
Brown MJ Brown Morris J MJ
Charoen P Charoen Pimphen P
Cucca F Cucca Francesco F
Das D Das Debashish D
de Geus EJ de Geus Eco J C EJ
Dixon AL Dixon Anna L AL
Döring A Döring Angela A
Ehret G Ehret Georg G
Eyjolfsson GI Eyjolfsson Gudmundur I GI
Farrall M Farrall Martin M
Forouhi NG Forouhi Nita G NG
Friedrich N Friedrich Nele N
Goessling W Goessling Wolfram W
Gudbjartsson DF Gudbjartsson Daniel F DF
Harris TB Harris Tamara B TB
Hartikainen AL Hartikainen Anna-Liisa AL
Heath S Heath Simon S
Hirschfield GM Hirschfield Gideon M GM
Hofman A Hofman Albert A
Homuth G Homuth Georg G
Hyppönen E Hyppönen Elina E
Janssen HL Janssen Harry L A HL
Johnson T Johnson Toby T
Kangas AJ Kangas Antti J AJ
Kema IP Kema Ido P IP
Kühn JP Kühn Jens P JP
Lai S Lai Sandra S
Lathrop M Lathrop Mark M
Lerch MM Lerch Markus M MM
Li Y Li Yun Y
Liang TJ Liang T Jake TJ
Lin JP Lin Jing-Ping JP
Loos RJ Loos Ruth J F RJ
Martin NG Martin Nicholas G NG
Moffatt MF Moffatt Miriam F MF
Montgomery GW Montgomery Grant W GW
Munroe PB Munroe Patricia B PB
Musunuru K Musunuru Kiran K
Nakamura Y Nakamura Yusuke Y
O'Donnell CJ O'Donnell Christopher J CJ
Olafsson I Olafsson Isleifur I
Penninx BW Penninx Brenda W BW
Pouta A Pouta Anneli A
Prins BP Prins Bram P BP
Prokopenko I Prokopenko Inga I
Puls R Puls Ralf R
Ruokonen A Ruokonen Aimo A
Savolainen MJ Savolainen Markku J MJ
Schlessinger D Schlessinger David D
Schouten JN Schouten Jeoffrey N L JN
Seedorf U Seedorf Udo U
Sen-Chowdhry S Sen-Chowdhry Srijita S
Siminovitch KA Siminovitch Katherine A KA
Smit JH Smit Johannes H JH
Spector TD Spector Timothy D TD
Tan W Tan Wenting W
Teslovich TM Teslovich Tanya M TM
Tukiainen T Tukiainen Taru T
Uitterlinden AG Uitterlinden Andre G AG
Van der Klauw MM Van der Klauw Melanie M MM
Vasan RS Vasan Ramachandran S RS
Wallace C Wallace Chris C
Wallaschofski H Wallaschofski Henri H
Wichmann HE Wichmann H-Erich HE
Willemsen G Willemsen Gonneke G
Würtz P Würtz Peter P
Xu C Xu Chun C
Yerges-Armstrong LM Yerges-Armstrong Laura M LM
Alcohol Genome-wide Association (AlcGen) Consortium
Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study
Genetic Investigation of Anthropometric Traits (GIANT) Consortium
Global Lipids Genetics Consortium
Genetics of Liver Disease (GOLD) Consortium
International Consortium for Blood Pressure (ICBP-GWAS)
Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC)
Abecasis GR Abecasis Goncalo R GR
Ahmadi KR Ahmadi Kourosh R KR
Boomsma DI Boomsma Dorret I DI
Caulfield M Caulfield Mark M
Cookson WO Cookson William O WO
van Duijn CM van Duijn Cornelia M CM
Froguel P Froguel Philippe P
Matsuda K Matsuda Koichi K
McCarthy MI McCarthy Mark I MI
Meisinger C Meisinger Christa C
Mooser V Mooser Vincent V
Pietiläinen KH Pietiläinen Kirsi H KH
Schumann G Schumann Gunter G
Snieder H Snieder Harold H
Sternberg MJ Sternberg Michael J E MJ
Stolk RP Stolk Ronald P RP
Thomas HC Thomas Howard C HC
Thorsteinsdottir U Thorsteinsdottir Unnur U
Uda M Uda Manuela M
Waeber G Waeber Gérard G
Wareham NJ Wareham Nicholas J NJ
Waterworth DM Waterworth Dawn M DM
Watkins H Watkins Hugh H
Whitfield JB Whitfield John B JB
Witteman JC Witteman Jacqueline C M JC
Wolffenbuttel BH Wolffenbuttel Bruce H R BH
Fox CS Fox Caroline S CS
Ala-Korpela M Ala-Korpela Mika M
Stefansson K Stefansson Kari K
Vollenweider P Vollenweider Peter P
Völzke H Völzke Henry H
Schadt EE Schadt Eric E EE
Scott J Scott James J
Järvelin MR Järvelin Marjo-Riitta MR
Elliott P Elliott Paul P
Kooner JS Kooner Jaspal S JS
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Voight Benjamin F BF
Scott Laura J LJ
Steinthorsdottir Valgerdur V
Morris Andrew P AP
Dina Christian C
Welch Ryan P RP
Zeggini Eleftheria E
Huth Cornelia C
Aulchenko Yurii S YS
Thorleifsson Gudmar G
McCulloch Laura J LJ
Ferreira Teresa T
Grallert Harald H
Amin Najaf N
Wu Guanming G
Willer Cristen J CJ
Raychaudhuri Soumya S
McCarroll Steve A SA
Langenberg Claudia C
Hofmann Oliver M OM
Dupuis Josée J
Qi Lu L
Segrè Ayellet V AV
van Hoek Mandy M
Navarro Pau P
Ardlie Kristin K
Balkau Beverley B
Benediktsson Rafn R
Bennett Amanda J AJ
Blagieva Roza R
Boerwinkle Eric E
Bonnycastle Lori L LL
Bengtsson Boström Kristina K
Bravenboer Bert B
Bumpstead Suzannah S
Burtt Noël P NP
Charpentier Guillaume G
Chines Peter S PS
Cornelis Marilyn M
Couper David J DJ
Crawford Gabe G
Doney Alex S F AS
Elliott Katherine S KS
Elliott Amanda L AL
Erdos Michael R MR
Fox Caroline S CS
Franklin Christopher S CS
Ganser Martha M
Gieger Christian C
Grarup Niels N
Green Todd T
Griffin Simon S
Groves Christopher J CJ
Guiducci Candace C
Hadjadj Samy S
Hassanali Neelam N
Herder Christian C
Isomaa Bo B
Jackson Anne U AU
Johnson Paul R V PR
Jørgensen Torben T
Kao Wen H L WH
Klopp Norman N
Kong Augustine A
Kraft Peter P
Kuusisto Johanna J
Lauritzen Torsten T
Li Man M
Lieverse Aloysius A
Lindgren Cecilia M CM
Lyssenko Valeriya V
Marre Michel M
Meitinger Thomas T
Midthjell Kristian K
Morken Mario A MA
Narisu Narisu N
Nilsson Peter P
Owen Katharine R KR
Payne Felicity F
Perry John R B JR
Petersen Ann-Kristin AK
Platou Carl C
Proença Christine C
Prokopenko Inga I
Rathmann Wolfgang W
William Rayner N N
Robertson Neil R NR
Rocheleau Ghislain G
Roden Michael M
Sampson Michael J MJ
Saxena Richa R
Shields Beverley M BM
Shrader Peter P
Sigurdsson Gunnar G
Sparsø Thomas T
Strassburger Klaus K
Stringham Heather M HM
Sun Qi Q
Swift Amy J AJ
Thorand Barbara B
Tichet Jean J
Tuomi Tiinamaija T
van Dam Rob M RM
van Haeften Timon W TW
van Herpt Thijs T
van Vliet-Ostaptchouk Jana V JV
Walters G Bragi GB
Weedon Michael N MN
Wijmenga Cisca C
Witteman Jacqueline J
Bergman Richard N RN
Cauchi Stephane S
Collins Francis S FS
Gloyn Anna L AL
Gyllensten Ulf U
Hansen Torben T
Hide Winston A WA
Hitman Graham A GA
Hofman Albert A
Hunter David J DJ
Hveem Kristian K
Laakso Markku M
Mohlke Karen L KL
Morris Andrew D AD
Palmer Colin N A CN
Pramstaller Peter P PP
Rudan Igor I
Sijbrands Eric E
Stein Lincoln D LD
Tuomilehto Jaakko J
Uitterlinden Andre A
Walker Mark M
Wareham Nicholas J NJ
Watanabe Richard M RM
Abecasis Goncalo R GR
Boehm Bernhard O BO
Campbell Harry H
Daly Mark J MJ
Hattersley Andrew T AT
Hu Frank B FB
Meigs James B JB
Pankow James S JS
Pedersen Oluf O
Wichmann H-Erich HE
Barroso Inês I
Florez Jose C JC
Frayling Timothy M TM
Groop Leif L
Sladek Rob R
Thorsteinsdottir Unnur U
Wilson James F JF
Illig Thomas T
Froguel Philippe P
van Duijn Cornelia M CM
Stefansson Kari K
Altshuler David D
Boehnke Michael M
McCarthy Mark I MI
Lango Allen H H
Estrada K K
Lettre G G
Berndt S I SI
Weedon M N MN
Rivadeneira F F
Willer C J CJ
Jackson A U AU
Vedantam S S
Raychaudhuri S S
Ferreira T T
Wood A R AR
Weyant R J RJ
Segrè A V AV
Speliotes E K EK
Wheeler E E
Soranzo N N
Park J H JH
Yang J J
Gudbjartsson D D
Heard-Costa N L NL
Randall J C JC
Qi L L
Smith A Vernon AV
Mägi R R
Pastinen T T
Liang L L
Heid I M IM
Luan J J
Thorleifsson G G
Winkler T W TW
Goddard M E ME
Sin Lo K K
Palmer C C
Workalemahu T T
Aulchenko Y S YS
Johansson A A
Zillikens M C MC
Feitosa M F MF
Esko T T
Johnson T T
Ketkar S S
Kraft P P
Mangino M M
Prokopenko I I
Absher D D
Albrecht E E
Ernst F F
Glazer N L NL
Hayward C C
Hottenga J J JJ
Jacobs K B KB
Knowles J W JW
Kutalik Z Z
Monda K L KL
Polasek O O
Preuss M M
Rayner N W NW
Robertson N R NR
Steinthorsdottir V V
Tyrer J P JP
Voight B F BF
Wiklund F F
Xu J J
Zhao J Hua JH
Nyholt D R DR
Pellikka N N
Perola M M
Perry J R JR
Surakka I I
Tammesoo M L ML
Altmaier E L EL
Amin N N
Aspelund T T
Bhangale T T
Boucher G G
Chasman D I DI
Chen C C
Coin L L
Cooper M N MN
Dixon A L AL
Gibson Q Q
Grundberg E E
Hao K K
Juhani Junttila M M
Kaplan L M LM
Kettunen J J
König I R IR
Kwan T T
Lawrence R W RW
Levinson D F DF
Lorentzon M M
McKnight B B
Morris A P AP
Müller M M
Suh Ngwa J J
Purcell S S
Rafelt S S
Salem R M RM
Salvi E E
Sanna S S
Shi J J
Sovio U U
Thompson J R JR
Turchin M C MC
Vandenput L L
Verlaan D J DJ
Vitart V V
White C C CC
Ziegler A A
Almgren P P
Balmforth A J AJ
Campbell H H
Citterio L L
De Grandi A A
Dominiczak A A
Duan J J
Elliott P P
Elosua R R
Eriksson J G JG
Freimer N B NB
Geus E J EJ
Glorioso N N
Haiqing S S
Hartikainen A L AL
Havulinna A S AS
Hicks A A AA
Hui J J
Igl W W
Illig T T
Jula A A
Kajantie E E
Kilpeläinen T O TO
Koiranen M M
Kolcic I I
Koskinen S S
Kovacs P P
Laitinen J J
Liu J J
Lokki M L ML
Marusic A A
Maschio A A
Meitinger T T
Mulas A A
Paré G G
Parker A N AN
Peden J F JF
Petersmann A A
Pichler I I
Pietiläinen K H KH
Pouta A A
Ridderstråle M M
Rotter J I JI
Sambrook J G JG
Sanders A R AR
Schmidt C Oliver CO
Sinisalo J J
Smit J H JH
Stringham H M HM
Walters G Bragi GB
Widen E E
Wild S H SH
Willemsen G G
Zagato L L
Zgaga L L
Zitting P P
Alavere H H
Farrall M M
McArdle W L WL
Nelis M M
Peters M J MJ
Ripatti S S
van Meurs J B JB
Aben K K KK
Ardlie K G KG
Beckmann J S JS
Beilby J P JP
Bergman R N RN
Bergmann S S
Collins F S FS
Cusi D D
den Heijer M M
Eiriksdottir G G
Gejman P V PV
Hamsten A A
Huikuri H V HV
Iribarren C C
Kähönen M M
Kaprio J J
Kathiresan S S
Kiemeney L L
Kocher T T
Launer L J LJ
Lehtimäki T T
Melander O O
Mosley T H TH
Musk A W AW
Nieminen M S MS
O'Donnell C J CJ
Ohlsson C C
Oostra B B
Palmer L J LJ
Raitakari O O
Ridker P M PM
Rioux J D JD
Rissanen A A
Rivolta C C
Schunkert H H
Shuldiner A R AR
Siscovick D S DS
Stumvoll M M
Tönjes A A
Tuomilehto J J
van Ommen G J GJ
Viikari J J
Heath A C AC
Martin N G NG
Montgomery G W GW
Province M A MA
Kayser M M
Arnold A M AM
Atwood L D LD
Boerwinkle E E
Chanock S J SJ
Deloukas P P
Gieger C C
Grönberg H H
Hall P P
Hattersley A T AT
Hengstenberg C C
Hoffman W W
Lathrop G Mark GM
Salomaa V V
Schreiber S S
Uda M M
Waterworth D D
Wright A F AF
Assimes T L TL
Barroso I I
Hofman A A
Mohlke K L KL
Boomsma D I DI
Caulfield M J MJ
Cupples L Adrienne LA
Erdmann J J
Fox C S CS
Gudnason V V
Gyllensten U U
Harris T B TB
Hayes R B RB
Jarvelin M R MR
Mooser V V
Munroe P B PB
Ouwehand W H WH
Penninx B W BW
Pramstaller P P PP
Quertermous T T
Rudan I I
Samani N J NJ
Spector T D TD
Völzke H H
Watkins H H
Wilson J F JF
Groop L C LC
Haritunians T T
Hu F B FB
Kaplan R C RC
Metspalu A A
North K E KE
Schlessinger D D
Wareham N J NJ
Hunter D J DJ
O'Connell J R JR
Strachan D P DP
Wichmann H E HE
Borecki I B IB
van Duijn C M CM
Schadt E E EE
Thorsteinsdottir U U
Peltonen L L
Uitterlinden A G AG
Visscher P M PM
Chatterjee N N
Loos R J RJ
Boehnke M M
McCarthy M I MI
Ingelsson E E
Lindgren C M CM
Abecasis G R GR
Stefansson K K
Frayling T M TM
Hirschhorn J N JN
Teslovich T M TM
Musunuru K K
Smith A V AV
Edmondson A C AC
Stylianou I M IM
Koseki M M
Pirruccello J P JP
Ripatti S S
Chasman D I DI
Willer C J CJ
Johansen C T CT
Fouchier S W SW
Isaacs A A
Peloso G M GM
Barbalic M M
Ricketts S L SL
Bis J C JC
Aulchenko Y S YS
Thorleifsson G G
Feitosa M F MF
Chambers J J
Orho-Melander M M
Melander O O
Johnson T T
Li X X
Guo X X
Li M M
Cho Y Shin YS
Go M Jin MJ
Kim Y Jin YJ
Lee J Y JY
Park T T
Kim K K
Sim X X
Ong R Twee-Hee RT
Croteau-Chonka D C DC
Lange L A LA
Smith J D JD
Song K K
Zhao J Hua JH
Yuan X X
Luan J J
Lamina C C
Ziegler A A
Zhang W W
Zee R Y RY
Wright A F AF
Witteman J C JC
Wilson J F JF
Willemsen G G
Wichmann H E HE
Whitfield J B JB
Waterworth D M DM
Wareham N J NJ
Waeber G G
Vollenweider P P
Voight B F BF
Vitart V V
Uitterlinden A G AG
Uda M M
Tuomilehto J J
Thompson J R JR
Tanaka T T
Surakka I I
Stringham H M HM
Spector T D TD
Soranzo N N
Smit J H JH
Sinisalo J J
Silander K K
Sijbrands E J EJ
Scuteri A A
Scott J J
Schlessinger D D
Sanna S S
Salomaa V V
Salomaa J J
Sabatti C C
Ruokonen A A
Rudan I I
Rose L M LM
Roberts R R
Rieder M M
Psaty B M BM
Pramstaller P P PP
Pichler I I
Perola M M
Penninx B W BW
Pedersen N L NL
Pattaro C C
Pare G G
Oostra B A BA
O'Donnell C J CJ
Nieminen M S MS
Nickerson D A DA
Montgomery G W GW
Meitinger T T
McPherson R R
McCarthy M I MI
McArdle W W
Masson D D
Martin N G NG
Marroni F F
Mangino M M
Magnusson P K PK
Lucas G G
Luben R R
Loos R J RJ
Lokki M L ML
Lettre G G
Langenberg C C
Launer L J LJ
Lakatta E G EG
Laaksonen R R
Kyvik K O KO
Kronenberg F F
König I R IR
Khaw K T KT
Kaprio J J
Kaplan L M LM
Johansson A A
Jarvelin M R MR
Janssens A C AC
Ingelsson E E
Igl W W
Hovingh G Kees GK
Hottenga J J JJ
Hofman A A
Hicks A A AA
Hengstenberg C C
Heid I M IM
Hayward C C
Havulinna A S AS
Hastie N D ND
Harris T B TB
Haritunians T T
Hall A S AS
Gyllensten U U
Guiducci C C
Groop L C LC
Gonzalez E E
Gieger C C
Gieger N B NB
Ferrucci L L
Erdmann J J
Elliott P P
Ejebe K G KG
Döring A A
Dominiczak A F AF
Demissie S S
Deloukas P P
de Geus E J EJ
de Faire U U
Crawford G G
Collins F S FS
Chen Y D YD
Caulfield M J MJ
Campbell H H
Burtt N P NP
Bonnycastle L L LL
Boomsma D I DI
Boekholdt S M SM
Bergman R N RN
Barroso I I
Bandinelli S S
Ballantyne C M CM
Ballantyne T L TL
Quertermous T T
Altshuler D D
Seielstad M M
Wong T Y TY
Tai E S ES
Feranil A B AB
Kuzawa C W CW
Adair L S LS
Taylor H A HA
Borecki I B IB
Gabriel S B SB
Wilson J G JG
Holm H H
Thorsteinsdottir U U
Gudnason V V
Krauss R M RM
Mohlke K L KL
Ordovas J M JM
Munroe P B PB
Kooner J S JS
Tall A R AR
Hegele R A RA
Kastelein J J JJ
Schadt E E EE
Rotter J I JI
Boerwinkle E E
Strachan D P DP
Mooser V V
Stefansson K K
Reilly M P MP
Samani N J NJ
Schunkert H H
Cupples L A LA
Sandhu M S MS
Ridker P M PM
Rader D J DJ
van Duijn C M CM
Peltonen L L
Abecasis G R GR
Boehnke M M
Kathiresan S S
Speliotes Elizabeth K EK
Yerges-Armstrong Laura M LM
Hernaez Ruben R
Kim Lauren J LJ
Palmer Cameron D CD
Gudnason Vilmundur V
Eiriksdottir Gudny G
Garcia Melissa E ME
Launer Lenore J LJ
Nalls Michael A MA
Clark Jeanne M JM
Mitchell Braxton D BD
Shuldiner Alan R AR
Butler Johannah L JL
Tomas Marta M
Hoffmann Udo U
Hwang Shih-Jen SJ
Massaro Joseph M JM
O'Donnell Christopher J CJ
Sahani Dushyant V DV
Salomaa Veikko V
Schadt Eric E EE
Schwartz Stephen M SM
Siscovick David S DS
Voight Benjamin F BF
Carr J Jeffrey JJ
Feitosa Mary F MF
Harris Tamara B TB
Fox Caroline S CS
Smith Albert V AV
Kao W H Linda WH
Hirschhorn Joel N JN
Borecki Ingrid B IB
Ehret Georg B GB
Munroe Patricia B PB
Rice Kenneth M KM
Bochud Murielle M
Johnson Andrew D AD
Chasman Daniel I DI
Smith Albert V AV
Tobin Martin D MD
Verwoert Germaine C GC
Hwang Shih-Jen SJ
Pihur Vasyl V
Vollenweider Peter P
O'Reilly Paul F PF
Amin Najaf N
Bragg-Gresham Jennifer L JL
Teumer Alexander A
Glazer Nicole L NL
Launer Lenore L
Zhao Jing Hua JH
Aulchenko Yurii Y
Heath Simon S
Sober Siim S
Parsa Afshin A
Luan Jian'an J
Arora Pankaj P
Dehghan Abbas A
Zhang Feng F
Lucas Gavin G
Hicks Andrew A AA
Jackson Anne U AU
Peden John F JF
Tanaka Toshiko T
Wild Sarah H SH
Rudan Igor I
Igl Wilmar W
Milaneschi Yuri Y
Parker Alex N AN
Fava Cristiano C
Chambers John C JC
Fox Ervin R ER
Kumari Meena M
Go Min Jin MJ
van der Harst Pim P
Kao Wen Hong Linda WH
Sjogren Marketa M
Vinay D G DG
Alexander Myriam M
Tabara Yasuharu Y
Shaw-Hawkins Sue S
Whincup Peter H PH
Liu Yongmei Y
Shi Gang G
Kuusisto Johanna J
Tayo Bamidele B
Seielstad Mark M
Sim Xueling X
Nguyen Khanh-Dung Hoang KD
Lehtimaki Terho T
Matullo Giuseppe G
Wu Ying Y
Gaunt Tom R TR
Onland-Moret N Charlotte NC
Cooper Matthew N MN
Platou Carl G P CG
Org Elin E
Hardy Rebecca R
Dahgam Santosh S
Palmen Jutta J
Vitart Veronique V
Braund Peter S PS
Kuznetsova Tatiana T
Uiterwaal Cuno S P M CS
Adeyemo Adebowale A
Palmas Walter W
Campbell Harry H
Ludwig Barbara B
Tomaszewski Maciej M
Tzoulaki Ioanna I
Palmer Nicholette D ND
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Chang Yen-Pei C YP
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Steinle Nanette I NI
Grobbee Diederick E DE
Arking Dan E DE
Kardia Sharon L SL
Morrison Alanna C AC
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Najjar Samer S
McArdle Wendy L WL
Hadley David D
Brown Morris J MJ
Connell John M JM
Hingorani Aroon D AD
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Lawlor Debbie A DA
Beilby John P JP
Lawrence Robert W RW
Clarke Robert R
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Li Yali Y
Young J H JH
Bis Joshua C JC
Kahonen Mika M
Viikari Jorma J
Adair Linda S LS
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Chen Ming-Huei MH
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Pattaro Cristian C
Bolton Judith A Hoffman JA
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Bergmann Sven S
Mooser Vincent V
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Frayling Timothy M TM
Islam Muhammad M
Jafar Tazeen H TH
Erdmann Jeanette J
Kulkarni Smita R SR
Bornstein Stefan R SR
Grassler Jurgen J
Groop Leif L
Voight Benjamin F BF
Kettunen Johannes J
Howard Philip P
Taylor Andrew A
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Khaw Kay-Tee KT
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Sun Yan V YV
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Artigas Maria Soler MS
Dong Yanbin Y
Snieder Harold H
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Zhu Haidong H
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Volker Uwe U
Volzke Henry H
Galan Pilar P
Hercberg Serge S
Lathrop Mark M
Zelenika Diana D
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Meschia James F JF
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Bandinelli Stefania S
Gyllensten Ulf B UB
Wright Alan F AF
Wilson James F JF
Ferrucci Luigi L
Farrall Martin M
Tuomilehto Jaakko J
Pramstaller Peter P PP
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Soranzo Nicole N
Sijbrands Eric J G EJ
Altshuler David D
Loos Ruth J F RJ
Shuldiner Alan R AR
Gieger Christian C
Meneton Pierre P
Uitterlinden Andre G AG
Wareham Nicholas J NJ
Gudnason Vilmundur V
Rotter Jerome I JI
Rettig Rainer R
Uda Manuela M
Strachan David P DP
Witteman Jacqueline C M JC
Hartikainen Anna-Liisa AL
Beckmann Jacques S JS
Boerwinkle Eric E
Vasan Ramachandran S RS
Boehnke Michael M
Larson Martin G MG
Jarvelin Marjo-Riitta MR
Psaty Bruce M BM
Abecasis Goncalo R GR
Chakravarti Aravinda A
Elliott Paul P
van Duijn Cornelia M CM
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Langenberg C C
Prokopenko I I
Saxena R R
Soranzo N N
Jackson A U AU
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Morris A P AP
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Barroso
JOURNAL
VOLUME: 43
ISSUE: 11
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2011
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
090532 Wellcome Trust United Kingdom
14136 Cancer Research UK United Kingdom
FS/10/011/27881 British Heart Foundation United Kingdom
G0100222 Medical Research Council United Kingdom
G0401527 Medical Research Council United Kingdom
G0601653 Medical Research Council United Kingdom
G0601966 Medical Research Council United Kingdom
G0700342 Medical Research Council United Kingdom
G0700931 Medical Research Council United Kingdom
G0701863 Medical Research Council United Kingdom
G0902037 Medical Research Council United Kingdom
G1000143 Medical Research Council United Kingdom
G19/35 Medical Research Council United Kingdom
G8802774 Medical Research Council United Kingdom
G9521010 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
MC_PC_U127561128 Medical Research Council United Kingdom
MC_U106179471 Medical Research Council United Kingdom
MC_U106188470 Medical Research Council United Kingdom
MC_U127561128 Medical Research Council United Kingdom
MC_UP_A100_1003 Medical Research Council United Kingdom
MC_UP_A620_1015 Medical Research Council United Kingdom
PG/09/002/26056 British Heart Foundation United Kingdom
PG/09/023/26806 British Heart Foundation United Kingdom
PHCS/C4/4/016 Department of Health United Kingdom
R01 HL087647 NHLBI NIH HHS United States
RG/07/008/23674 British Heart Foundation United Kingdom
Z99 DK999999 Intramural NIH HHS United States
ZIA DK075013-05 Intramural NIH HHS United States
ZIA DK075013-07 Intramural NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Enzymes genetics
Genome-Wide Association Study genetics
Humans genetics
Liver enzymology
Polymorphism, Single Nucleotide enzymology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Enzymes
OTHER ID's
OTHERID SOURCE
NIHMS411128 NLM
PMC3482372 NLM
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