Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21856034
TITLE
Complement activation as a biomarker for Alzheimer's disease.
ABSTRACT
There is increasing evidence from genetic, immunohistochemical, proteomic and epidemiological studies as well as in model systems that complement activation has an important role in the pathogenesis of Alzheimer's disease (AD). The complement cascade is an essential element of the innate immune response. In the brain complement proteins are integral components of amyloid plaques and complement activation occurs at the earliest stage of the disease. The complement cascade has been implicated as a protective mechanism in the clearance of amyloid, and in a causal role through chronic activation of the inflammatory response. In this review we discuss the potential for complement activation to act as a biomarker for AD at several stages in the disease process. An accurate biomarker that has sufficient predictive, diagnostic and prognostic value would provide a significant opportunity to develop and test for effective novel therapies in the treatment of AD.
Copyright © 2011 Elsevier GmbH. All rights reserved.
DATE PUBLISHED
2012 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/05/07
revised 2011/06/22
accepted 2011/07/18
aheadofprint 2011/07/23
entrez 2011/08/23 06:00
pubmed 2011/08/23 06:00
medline 2012/06/14 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Aiyaz M Aiyaz Mohammed M Kings College London Institute of Psychiatry, De Crespigny Park, London, UK.
Lupton MK Lupton Michelle K MK
Proitsi P Proitsi Petroula P
Powell JF Powell John F JF
Lovestone S Lovestone Simon S
INVESTIGATORS
JOURNAL
VOLUME: 217
ISSUE: 2
TITLE: Immunobiology
ISOABBREVIATION: Immunobiology
YEAR: 2012
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1878-3279
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Immunobiology
COUNTRY: Netherlands
ISSNLINKING: 0171-2985
NLMUNIQUEID: 8002742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Review
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alzheimer Disease pathology
Amyloid immunology
Biomarkers immunology
Complement Activation immunology
Complement System Proteins immunology
Humans immunology
Macular Degeneration immunology
Plaque, Amyloid pathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Amyloid
0 Biomarkers
9007-36-7 Complement System Proteins
OTHER ID's