| PMID |
|
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| TITLE |
|
| No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. |
|
| ABSTRACT |
|
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| We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease. |
| Copyright © 2011 Wiley-Liss, Inc. |
|
| DATE PUBLISHED |
|
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2011/01/06 |
| accepted |
2011/06/09 |
| aheadofprint |
2011/08/02 |
| entrez |
2011/08/04 06:00 |
| pubmed |
2011/08/04 06:00 |
| medline |
2012/01/18 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Sims R |
|
Sims |
Rebecca |
R |
|
MRC Centre for Neuropyschiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Heath Park. simsrc@cardiff.ac.uk |
| Dwyer S |
|
Dwyer |
Sarah |
S |
|
|
| Harold D |
|
Harold |
Denise |
D |
|
|
| Gerrish A |
|
Gerrish |
Amy |
A |
|
|
| Hollingworth P |
|
Hollingworth |
Paul |
P |
|
|
| Chapman J |
|
Chapman |
Jade |
J |
|
|
| Jones N |
|
Jones |
Nicola |
N |
|
|
| Abraham R |
|
Abraham |
Richard |
R |
|
|
| Ivanov D |
|
Ivanov |
Dobril |
D |
|
|
| Pahwa JS |
|
Pahwa |
Jaspreet Singh |
JS |
|
|
| Moskvina V |
|
Moskvina |
Valentina |
V |
|
|
| Dowzell K |
|
Dowzell |
Kimberley |
K |
|
|
| Thomas C |
|
Thomas |
Charlene |
C |
|
|
| Stretton A |
|
Stretton |
Alexandra |
A |
|
|
| Lovestone S |
|
Lovestone |
Simon |
S |
|
|
| Powell J |
|
Powell |
John |
J |
|
|
| Proitsi P |
|
Proitsi |
Petroula |
P |
|
|
| Lupton MK |
|
Lupton |
Michelle K |
MK |
|
|
| Brayne C |
|
Brayne |
Carol |
C |
|
|
| Rubinsztein DC |
|
Rubinsztein |
David C |
DC |
|
|
| Gill M |
|
Gill |
Michael |
M |
|
|
| Lawlor B |
|
Lawlor |
Brian |
B |
|
|
| Lynch A |
|
Lynch |
Aoibhinn |
A |
|
|
| Morgan K |
|
Morgan |
Kevin |
K |
|
|
| Brown KS |
|
Brown |
Kristelle S |
KS |
|
|
| Passmore PA |
|
Passmore |
Peter A |
PA |
|
|
| Craig D |
|
Craig |
David |
D |
|
|
| McGuiness B |
|
McGuiness |
Bernadette |
B |
|
|
| Todd S |
|
Todd |
Stephen |
S |
|
|
| Johnston JA |
|
Johnston |
Janet A |
JA |
|
|
| Holmes C |
|
Holmes |
Clive |
C |
|
|
| Mann D |
|
Mann |
David |
D |
|
|
| Smith AD |
|
Smith |
A David |
AD |
|
|
| Love S |
|
Love |
Seth |
S |
|
|
| Kehoe PG |
|
Kehoe |
Patrick G |
PG |
|
|
| Hardy J |
|
Hardy |
John |
J |
|
|
| Mead S |
|
Mead |
Simon |
S |
|
|
| Fox N |
|
Fox |
Nick |
N |
|
|
| Rossor M |
|
Rossor |
Martin |
M |
|
|
| Collinge J |
|
Collinge |
John |
J |
|
|
| Livingston G |
|
Livingston |
Gill |
G |
|
|
| Bass NJ |
|
Bass |
Nicholas J |
NJ |
|
|
| Gurling H |
|
Gurling |
Hugh |
H |
|
|
| McQuillin A |
|
McQuillin |
Andrew |
A |
|
|
| Jones L |
|
Jones |
Lesley |
L |
|
|
| Holmans PA |
|
Holmans |
Peter A |
PA |
|
|
| O'Donovan M |
|
O'Donovan |
Michael |
M |
|
|
| Owen MJ |
|
Owen |
Michael J |
MJ |
|
|
| Williams J |
|
Williams |
Julie |
J |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 156B |
| ISSUE: 7 |
| TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics |
| ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet. |
| YEAR: 2011 |
| MONTH: Dec |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1552-485X |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Am J Med Genet B Neuropsychiatr Genet |
| COUNTRY: United States |
| ISSNLINKING: 1552-4841 |
| NLMUNIQUEID: 101235742 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| G0601846 |
Medical Research Council |
United Kingdom |
| G0701075 |
Medical Research Council |
United Kingdom |
| G0801306 |
Medical Research Council |
United Kingdom |
| G0902227 |
Medical Research Council |
United Kingdom |
| MC_U123160651 |
Medical Research Council |
United Kingdom |
| MR/K01417X/1 |
Medical Research Council |
United Kingdom |
|
Medical Research Council |
United Kingdom |
|
Wellcome Trust |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Aged |
|
| Aged, 80 and over |
|
| Alzheimer Disease |
genetics |
| Case-Control Studies |
genetics |
| Chromosomes, Human, Pair 8 |
genetics |
| Female |
genetics |
| Genes |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Genome-Wide Association Study |
genetics |
| Homozygote |
genetics |
| Humans |
genetics |
| Male |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
