Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21795540
TITLE
Heritability of working memory brain activation.
ABSTRACT
Although key to understanding individual variation in task-related brain activation, the genetic contribution to these individual differences remains largely unknown. Here we report voxel-by-voxel genetic model fitting in a large sample of 319 healthy, young adult, human identical and fraternal twins (mean ± SD age, 23.6 ± 1.8 years) who performed an n-back working memory task during functional magnetic resonance imaging (fMRI) at a high magnetic field (4 tesla). Patterns of task-related brain response (BOLD signal difference of 2-back minus 0-back) were significantly heritable, with the highest estimates (40-65%) in the inferior, middle, and superior frontal gyri, left supplementary motor area, precentral and postcentral gyri, middle cingulate cortex, superior medial gyrus, angular gyrus, superior parietal lobule, including precuneus, and superior occipital gyri. Furthermore, high test-retest reliability for a subsample of 40 twins indicates that nongenetic variance in the fMRI brain response is largely due to unique environmental influences rather than measurement error. Individual variations in activation of the working memory network are therefore significantly influenced by genetic factors. By establishing the heritability of cognitive brain function in a large sample that affords good statistical power, and using voxel-by-voxel analyses, this study provides the necessary evidence for task-related brain activation to be considered as an endophenotype for psychiatric or neurological disorders, and represents a substantial new contribution to the field of neuroimaging genetics. These genetic brain maps should facilitate discovery of gene variants influencing cognitive brain function through genome-wide association studies, potentially opening up new avenues in the treatment of brain disorders.
DATE PUBLISHED
2011 Jul 27
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2011/07/29 06:00
pubmed 2011/07/29 06:00
medline 2011/10/08 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Blokland GA Blokland Gabriëlla A M GA Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia. gabriella.blokland@qimr.edu.au
McMahon KL McMahon Katie L KL
Thompson PM Thompson Paul M PM
Martin NG Martin Nicholas G NG
de Zubicaray GI de Zubicaray Greig I GI
Wright MJ Wright Margaret J MJ
INVESTIGATORS
JOURNAL
VOLUME: 31
ISSUE: 30
TITLE: The Journal of neuroscience : the official journal of the Society for Neuroscience
ISOABBREVIATION: J. Neurosci.
YEAR: 2011
MONTH: Jul
DAY: 27
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1529-2401
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Neurosci
COUNTRY: United States
ISSNLINKING: 0270-6474
NLMUNIQUEID: 8102140
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 HD050735 NICHD NIH HHS United States
R01 HD050735-05 NICHD NIH HHS United States
R01HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Brain physiology
Brain Mapping physiology
Environment physiology
Female physiology
Genotype physiology
Humans physiology
Image Processing, Computer-Assisted physiology
Intelligence Tests physiology
Magnetic Resonance Imaging physiology
Male physiology
Memory, Short-Term physiology
Models, Genetic physiology
Oxygen blood
Psychometrics blood
Reaction Time genetics
Reproducibility of Results genetics
Sex Factors genetics
Social Class genetics
Statistics as Topic genetics
Twin Studies as Topic genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
S88TT14065 Oxygen
OTHER ID's
OTHERID SOURCE
NIHMS314782 NLM
PMC3163233 NLM
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