Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21655089
TITLE
Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.
ABSTRACT
DATE PUBLISHED
2011 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/03/05
accepted 2011/04/08
epublish 2011/06/02
entrez 2011/06/10 06:00
pubmed 2011/06/10 06:00
medline 2011/09/29 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Tomlinson IP Tomlinson Ian P M IP Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Carvajal-Carmona LG Carvajal-Carmona Luis G LG
Dobbins SE Dobbins Sara E SE
Tenesa A Tenesa Albert A
Jones AM Jones Angela M AM
Howarth K Howarth Kimberley K
Palles C Palles Claire C
Broderick P Broderick Peter P
Jaeger EE Jaeger Emma E M EE
Farrington S Farrington Susan S
Lewis A Lewis Annabelle A
Prendergast JG Prendergast James G D JG
Pittman AM Pittman Alan M AM
Theodoratou E Theodoratou Evropi E
Olver B Olver Bianca B
Walker M Walker Marion M
Penegar S Penegar Steven S
Barclay E Barclay Ella E
Whiffin N Whiffin Nicola N
Martin L Martin Lynn L
Ballereau S Ballereau Stephane S
Lloyd A Lloyd Amy A
Gorman M Gorman Maggie M
Lubbe S Lubbe Steven S
COGENT Consortium
CORGI Collaborators
EPICOLON Consortium
Howie B Howie Bryan B
Marchini J Marchini Jonathan J
Ruiz-Ponte C Ruiz-Ponte Clara C
Fernandez-Rozadilla C Fernandez-Rozadilla Ceres C
Castells A Castells Antoni A
Carracedo A Carracedo Angel A
Castellvi-Bel S Castellvi-Bel Sergi S
Duggan D Duggan David D
Conti D Conti David D
Cazier JB Cazier Jean-Baptiste JB
Campbell H Campbell Harry H
Sieber O Sieber Oliver O
Lipton L Lipton Lara L
Gibbs P Gibbs Peter P
Martin NG Martin Nicholas G NG
Montgomery GW Montgomery Grant W GW
Young J Young Joanne J
Baird PN Baird Paul N PN
Gallinger S Gallinger Steven S
Newcomb P Newcomb Polly P
Hopper J Hopper John J
Jenkins MA Jenkins Mark A MA
Aaltonen LA Aaltonen Lauri A LA
Kerr DJ Kerr David J DJ
Cheadle J Cheadle Jeremy J
Pharoah P Pharoah Paul P
Casey G Casey Graham G
Houlston RS Houlston Richard S RS
Dunlop MG Dunlop Malcolm G MG
INVESTIGATORS
JOURNAL
MEDLINE JOURNAL
MEDLINETA: PLoS Genet
COUNTRY: United States
ISSNLINKING: 1553-7390
NLMUNIQUEID: 101239074
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
075491/Z/04 Wellcome Trust United Kingdom
090532 Wellcome Trust United Kingdom
12076 Cancer Research UK United Kingdom
A10119 Cancer Research UK United Kingdom
A10124 Cancer Research UK United Kingdom
C31250/A10107 Cancer Research UK United Kingdom
CA-95-011 NCI NIH HHS United States
CZB/4/449 Chief Scientist Office United Kingdom
G0000657-53203 Medical Research Council United Kingdom
G0301096 Medical Research Council United Kingdom
MC_U127527198 Medical Research Council United Kingdom
MR/K001744/1 Medical Research Council United Kingdom
UO1 CA074783 NCI NIH HHS United States
UO1 CA074794 NCI NIH HHS United States
UO1 CA074799 NCI NIH HHS United States
UO1 CA074800 NCI NIH HHS United States
UO1 CA074806 NCI NIH HHS United States
UO1 CA097735 NCI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Aged
Bone Morphogenetic Protein 2 metabolism
Bone Morphogenetic Protein 4 metabolism
Case-Control Studies metabolism
Colorectal Neoplasms metabolism
Gene Frequency metabolism
Genetic Predisposition to Disease metabolism
Genetic Variation metabolism
Genome-Wide Association Study metabolism
Humans metabolism
Intercellular Signaling Peptides and Proteins genetics
Male genetics
Middle Aged genetics
Polymorphism, Single Nucleotide genetics
Quantitative Trait, Heritable genetics
Signal Transduction genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 BMP2 protein, human
0 BMP4 protein, human
0 Bone Morphogenetic Protein 2
0 Bone Morphogenetic Protein 4
0 GREM1 protein, human
0 Intercellular Signaling Peptides and Proteins
OTHER ID's
OTHERID SOURCE
PMC3107194 NLM