Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21599726
TITLE
Risk for suicidal thoughts and behavior after childhood sexual abuse in women and men.
ABSTRACT
Earlier studies have found an elevated risk for psychopathology and suicidal behavior associated with childhood sexual abuse (CSA); however, the degree to which risk is mediated by depression and posttraumatic stress disorder (PTSD) in women and men remains unclear. We examined these issues in data from a family study of childhood maltreatment (N = 2,559). We found significant CSA-associated risk for depression, PTSD, and suicidal behavior for women and men. In survival analyses controlling for these disorders, we observed persistent but somewhat reduced CSA-associated risk for suicidal ideation and suicide attempt. Our findings suggest that these disorders partially mediate CSA-associated risk.
2011 The American Association of Suicidology.
DATE PUBLISHED
2011 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2011/05/20
entrez 2011/05/24 06:00
pubmed 2011/05/24 06:00
medline 2011/12/14 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Bedi S Bedi Saaniya S Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Nelson EC Nelson Elliot C EC
Lynskey MT Lynskey Michael T MT
McCutcheon VV McCutcheon Vivia V VV
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 41
ISSUE: 4
TITLE: Suicide & life-threatening behavior
ISOABBREVIATION: Suicide Life Threat Behav
YEAR: 2011
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1943-278X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Suicide Life Threat Behav
COUNTRY: United States
ISSNLINKING: 0363-0234
NLMUNIQUEID: 7608054
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
K01 AA018146 NIAAA NIH HHS United States
K01 AA018146-03 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
P60 AA011998 NIAAA NIH HHS United States
R01 AA013446 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Child
Child Abuse, Sexual psychology
Depressive Disorder, Major psychology
Female psychology
Humans psychology
Interview, Psychological psychology
Male psychology
Odds Ratio psychology
Proportional Hazards Models psychology
Regression Analysis psychology
Risk Factors psychology
Sex Factors psychology
Siblings psychology
Stress Disorders, Post-Traumatic psychology
Suicidal Ideation psychology
Suicide, Attempted statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS415967 NLM
PMC3518050 NLM