Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21552263
TITLE
Genome partitioning of genetic variation for complex traits using common SNPs.
ABSTRACT
We estimate and partition genetic variation for height, body mass index (BMI), von Willebrand factor and QT interval (QTi) using 586,898 SNPs genotyped on 11,586 unrelated individuals. We estimate that ∼45%, ∼17%, ∼25% and ∼21% of the variance in height, BMI, von Willebrand factor and QTi, respectively, can be explained by all autosomal SNPs and a further ∼0.5-1% can be explained by X chromosome SNPs. We show that the variance explained by each chromosome is proportional to its length, and that SNPs in or near genes explain more variation than SNPs between genes. We propose a new approach to estimate variation due to cryptic relatedness and population stratification. Our results provide further evidence that a substantial proportion of heritability is captured by common SNPs, that height, BMI and QTi are highly polygenic traits, and that the additive variation explained by a part of the genome is approximately proportional to the total length of DNA contained within genes therein.
DATE PUBLISHED
2011 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2010/11/29
accepted 2011/04/07
aheadofprint 2011/05/08
entrez 2011/05/10 06:00
pubmed 2011/05/10 06:00
medline 2011/07/27 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Yang J Yang Jian J Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Manolio TA Manolio Teri A TA
Pasquale LR Pasquale Louis R LR
Boerwinkle E Boerwinkle Eric E
Caporaso N Caporaso Neil N
Cunningham JM Cunningham Julie M JM
de Andrade M de Andrade Mariza M
Feenstra B Feenstra Bjarke B
Feingold E Feingold Eleanor E
Hayes MG Hayes M Geoffrey MG
Hill WG Hill William G WG
Landi MT Landi Maria Teresa MT
Alonso A Alonso Alvaro A
Lettre G Lettre Guillaume G
Lin P Lin Peng P
Ling H Ling Hua H
Lowe W Lowe William W
Mathias RA Mathias Rasika A RA
Melbye M Melbye Mads M
Pugh E Pugh Elizabeth E
Cornelis MC Cornelis Marilyn C MC
Weir BS Weir Bruce S BS
Goddard ME Goddard Michael E ME
Visscher PM Visscher Peter M PM
INVESTIGATORS
JOURNAL
VOLUME: 43
ISSUE: 6
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2011
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
U01 HG 004399 NHGRI NIH HHS United States
U01 HG 004402 NHGRI NIH HHS United States
U01 HG 004446 NHGRI NIH HHS United States
U01 HG 004728 NHGRI NIH HHS United States
U01 HG004399 NHGRI NIH HHS United States
U01 HG004402 NHGRI NIH HHS United States
U01 HG004424 NHGRI NIH HHS United States
U01 HG004446 NHGRI NIH HHS United States
U01 HG004728 NHGRI NIH HHS United States
U01 HG04424 NHGRI NIH HHS United States
Canadian Institutes of Health Research Canada
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Body Height genetics
Body Mass Index genetics
Chromosomes genetics
Chromosomes, Human, X genetics
Genetic Variation genetics
Genetics, Population genetics
Genome-Wide Association Study genetics
Humans genetics
Models, Genetic genetics
Polymorphism, Single Nucleotide genetics
X Chromosome Inactivation genetics
von Willebrand Factor genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 von Willebrand Factor
OTHER ID's
OTHERID SOURCE
NIHMS650238 NLM
PMC4295936 NLM
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