Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21507154
TITLE
No association of candidate genes with cannabis use in a large sample of Australian twin families.
ABSTRACT
While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies.
2011 The Authors, Addiction Biology 2011 Society for the Study of Addiction.
DATE PUBLISHED
2012 May
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2011/04/20
entrez 2011/04/22 06:00
pubmed 2011/04/22 06:00
medline 2012/08/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Verweij KJ Verweij Karin J H KJ Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Australia. karin.verweij@qimr.edu.au
Zietsch BP Zietsch Brendan P BP
Liu JZ Liu Jimmy Z JZ
Medland SE Medland Sarah E SE
Lynskey MT Lynskey Michael T MT
Madden PA Madden Pamela A F PA
Agrawal A Agrawal Arpana A
Montgomery GW Montgomery Grant W GW
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 17
ISSUE: 3
TITLE: Addiction biology
ISOABBREVIATION: Addict Biol
YEAR: 2012
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1369-1600
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Addict Biol
COUNTRY: United States
ISSNLINKING: 1355-6215
NLMUNIQUEID: 9604935
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Biol Psychiatry. 2005 May 15;57(10):1117-27 15866551
Cites Addiction. 2006 Jun;101(6):801-12 16696624
Cites Am J Hum Genet. 2007 Nov;81(5):913-26 17924335
Cites Mol Psychiatry. 2011 May;16(5):516-32 20351714
Cites Am J Hum Genet. 2009 Nov;85(5):750-5 19896111
Cites Addiction. 2010 Mar;105(3):417-30 20402985
Cites Am J Hum Genet. 2010 Jul 9;87(1):139-45 20598278
Cites Addiction. 2009 Apr;104(4):518-32 19335651
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
DA12854 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH66206 NIMH NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia
Female
Genes genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Humans genetics
Male genetics
Marijuana Abuse genetics
Middle Aged genetics
Pedigree genetics
Polymorphism, Single Nucleotide genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS387320 NLM
PMC3393887 NLM