| PMID |
|
|
| TITLE |
|
| No association of candidate genes with cannabis use in a large sample of Australian twin families. |
|
| ABSTRACT |
|
|
|
| While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies. |
| © 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2011/04/22 06:00 |
| pubmed |
2011/04/22 06:00 |
| medline |
2012/08/07 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Verweij KJ |
|
Verweij |
Karin J H |
KJ |
|
Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Australia. karin.verweij@qimr.edu.au |
| Zietsch BP |
|
Zietsch |
Brendan P |
BP |
|
|
| Liu JZ |
|
Liu |
Jimmy Z |
JZ |
|
|
| Medland SE |
|
Medland |
Sarah E |
SE |
|
|
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 17 |
| ISSUE: 3 |
| TITLE: Addiction biology |
| ISOABBREVIATION: Addict Biol |
| YEAR: 2012 |
| MONTH: May |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1369-1600 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Addict Biol |
| COUNTRY: United States |
| ISSNLINKING: 1355-6215 |
| NLMUNIQUEID: 9604935 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Biol Psychiatry. 2005 May 15;57(10):1117-27 |
15866551 |
|
| Cites |
Addiction. 2006 Jun;101(6):801-12 |
16696624 |
|
| Cites |
Am J Hum Genet. 2007 Nov;81(5):913-26 |
17924335 |
|
| Cites |
Mol Psychiatry. 2011 May;16(5):516-32 |
20351714 |
|
| Cites |
Am J Hum Genet. 2009 Nov;85(5):750-5 |
19896111 |
|
| Cites |
Addiction. 2010 Mar;105(3):417-30 |
20402985 |
|
| Cites |
Am J Hum Genet. 2010 Jul 9;87(1):139-45 |
20598278 |
|
| Cites |
Addiction. 2009 Apr;104(4):518-32 |
19335651 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 AA007535 |
NIAAA NIH HHS |
United States |
| R01 AA014041 |
NIAAA NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| R01 MH066206 |
NIMH NIH HHS |
United States |
| AA13320 |
NIAAA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| AA10248 |
NIAAA NIH HHS |
United States |
| R01 AA013326 |
NIAAA NIH HHS |
United States |
| R56 DA012854 |
NIDA NIH HHS |
United States |
| MH66206 |
NIMH NIH HHS |
United States |
| R01 AA013321 |
NIAAA NIH HHS |
United States |
| R01 DA012854 |
NIDA NIH HHS |
United States |
| AA14041 |
NIAAA NIH HHS |
United States |
| AA13326 |
NIAAA NIH HHS |
United States |
| R01 AA013320 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Australia |
|
| Female |
|
| Genes |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Genome-Wide Association Study |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Marijuana Abuse |
genetics |
| Middle Aged |
genetics |
| Pedigree |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
