|
|
| PMID |
|
|
| TITLE |
|
| Ophthalmic phenotypes and the representativeness of twin data for the general population. |
|
| ABSTRACT |
|
| PURPOSE |
NlmCategory: OBJECTIVE |
| To compare the distributional parameters for a series of ocular biometric traits between twins and their singleton siblings, to evaluate the generalizability of twin data, as used in heritability analyses to the general population. |
| METHODS |
NlmCategory: METHODS |
| To compare the distributional parameters for a series of ocular biometric traits between twins and their singleton siblings, to evaluate the generalizability of twin data, as used in heritability analyses to the general population. A series of birth, anthropometric, and 13 ocular biometric traits were selected for analysis: interpupillary distance (IPD), visual acuity (logMAR), spherical equivalent refractive error, corneal curvature, axial length, anterior chamber depth (ACD), central corneal thickness (CCT), intraocular pressure (IOP), optic disc, cup and rim areas, and measures of retinal vessel caliber; central retinal arteriolar equivalent (CRAE), and central retinal venular equivalent (CRVE). Structural equation modeling was used to test the assumption that the means and variances for each trait did not differ between twins and their siblings. |
| RESULTS |
NlmCategory: RESULTS |
| To compare the distributional parameters for a series of ocular biometric traits between twins and their singleton siblings, to evaluate the generalizability of twin data, as used in heritability analyses to the general population. A series of birth, anthropometric, and 13 ocular biometric traits were selected for analysis: interpupillary distance (IPD), visual acuity (logMAR), spherical equivalent refractive error, corneal curvature, axial length, anterior chamber depth (ACD), central corneal thickness (CCT), intraocular pressure (IOP), optic disc, cup and rim areas, and measures of retinal vessel caliber; central retinal arteriolar equivalent (CRAE), and central retinal venular equivalent (CRVE). Structural equation modeling was used to test the assumption that the means and variances for each trait did not differ between twins and their siblings. Significant differences in log-likelihood for birth weight and gestational age were observed between twins and siblings, with the latter being both heavier and closer to full-term at birth. Siblings were also found to have larger IPD and axial length, and better visual acuity compared with their twin counterparts. Refractive error, corneal curvature, ACD, CCT, optic disc parameters, and retinal vascular calibers did not differ significantly between the two groups. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| To compare the distributional parameters for a series of ocular biometric traits between twins and their singleton siblings, to evaluate the generalizability of twin data, as used in heritability analyses to the general population. A series of birth, anthropometric, and 13 ocular biometric traits were selected for analysis: interpupillary distance (IPD), visual acuity (logMAR), spherical equivalent refractive error, corneal curvature, axial length, anterior chamber depth (ACD), central corneal thickness (CCT), intraocular pressure (IOP), optic disc, cup and rim areas, and measures of retinal vessel caliber; central retinal arteriolar equivalent (CRAE), and central retinal venular equivalent (CRVE). Structural equation modeling was used to test the assumption that the means and variances for each trait did not differ between twins and their siblings. Significant differences in log-likelihood for birth weight and gestational age were observed between twins and siblings, with the latter being both heavier and closer to full-term at birth. Siblings were also found to have larger IPD and axial length, and better visual acuity compared with their twin counterparts. Refractive error, corneal curvature, ACD, CCT, optic disc parameters, and retinal vascular calibers did not differ significantly between the two groups. Twins are representative of the general population for some but not all measures of ocular biometry. Consequently, care should be taken when extrapolating twin data for these traits in heritability and other genetic studies. Birth weight differences between twins and siblings do not appear to account for the differences in ocular biometry observed in this study. |
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| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2011/04/19 06:00 |
| pubmed |
2011/04/19 06:00 |
| medline |
2011/10/01 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Sanfilippo PG |
|
Sanfilippo |
Paul G |
PG |
|
Centre for Eye Research Australia, Department of Ophthalmology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
|
| Hewitt AW |
|
Hewitt |
Alex W |
AW |
|
|
| Kearns LS |
|
Kearns |
Lisa S |
LS |
|
|
| Ruddle JB |
|
Ruddle |
Jonathan B |
JB |
|
|
| Sun C |
|
Sun |
Cong |
C |
|
|
| Hammond CJ |
|
Hammond |
Christopher J |
CJ |
|
|
| Young TL |
|
Young |
Terri L |
TL |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Mackey DA |
|
Mackey |
David A |
DA |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 52 |
| ISSUE: 8 |
| TITLE: Investigative ophthalmology & visual science |
| ISOABBREVIATION: Invest Ophthalmol Vis Sci |
| YEAR: 2011 |
| MONTH: Jul |
| DAY: 29 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1552-5783 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Invest Ophthalmol Vis Sci |
| COUNTRY: United States |
| ISSNLINKING: 0146-0404 |
| NLMUNIQUEID: 7703701 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Invest Ophthalmol Vis Sci. 2003 Mar;44(3):953-60 |
12601014 |
|
| Cites |
Obes Res. 2002 Sep;10(9):875-84 |
12226135 |
|
| Cites |
Br J Ophthalmol. 2004 Apr;88(4):538-42 |
15031173 |
|
| Cites |
Best Pract Res Clin Obstet Gynaecol. 2004 Aug;18(4):625-30 |
15279821 |
|
| Cites |
Acta Ophthalmol (Copenh). 1981 Feb;59(1):64-70 |
7211284 |
|
| Cites |
Bull N Y Acad Med. 1990 Nov-Dec;66(6):618-37 |
2282443 |
|
| Cites |
Hum Neurobiol. 1984;3(2):87-92 |
6547705 |
|
| Cites |
Acta Paediatr Scand. 1982 Jul;71(4):645-50 |
7136682 |
|
| Cites |
Acta Ophthalmol Scand. 1996 Jun;74(3):301-5 |
8828732 |
|
| Cites |
J Pediatr. 1998 May;132(5):768-76 |
9602184 |
|
| Cites |
Clin Sci (Lond). 1998 Aug;95(2):115-28 |
9680492 |
|
| Cites |
Behav Genet. 2005 Jul;35(4):499-505 |
15971030 |
|
| Cites |
Br J Ophthalmol. 2006 Apr;90(4):456-60 |
16547327 |
|
| Cites |
Genet Epidemiol. 2008 May;32(4):341-9 |
18271028 |
|
| Cites |
Ophthalmology. 2008 Jun;115(6):1053-1057.e2 |
17964656 |
|
| Cites |
Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4790-4 |
18586876 |
|
| Cites |
Twin Res Hum Genet. 2009 Feb;12(1):86-92 |
19210183 |
|
| Cites |
Hypertension. 2009 Mar;53(3):487-93 |
19139377 |
|
| Cites |
Ophthalmology. 2009 Jun;116(6):1112-8 |
19395087 |
|
| Cites |
Psychol Bull. 1992 Jul;112(1):155-9 |
19565683 |
|
| Cites |
Hypertension. 2009 Oct;54(4):788-95 |
19687348 |
|
| Cites |
Twin Res Hum Genet. 2009 Oct;12(5):441-54 |
19803772 |
|
| Cites |
Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5115-9 |
19420339 |
|
| Cites |
J Pediatr. 2010 Apr;156(4):586-91 |
20036377 |
|
| Cites |
PLoS Genet. 2010 May;6(5):e1000947 |
20485516 |
|
| Cites |
Hum Mol Genet. 2010 Jul 1;19(13):2716-24 |
20395239 |
|
| Cites |
Surv Ophthalmol. 2010 Nov-Dec;55(6):561-83 |
20851442 |
|
| Cites |
Arch Ophthalmol. 2011 Jan;129(1):63-8 |
21220630 |
|
| Cites |
Am J Obstet Gynecol. 2000 May;182(5):1250-7 |
10819867 |
|
| Cites |
Semin Perinatol. 2000 Aug;24(4):291-8 |
10975435 |
|
| Cites |
Hypertension. 2000 Dec;36(6):1008-12 |
11116116 |
|
| Cites |
Obstet Gynecol. 2001 Jul;98(1):57-64 |
11430957 |
|
| Cites |
Pediatrics. 2002 Jan;109(1):12-8 |
11773536 |
|
| Cites |
Twin Res. 2001 Dec;4(6):464-77 |
11780939 |
|
| Cites |
Twin Res. 2001 Oct;4(5):385-91 |
11869493 |
|
| Cites |
Eur J Ophthalmol. 2003 Jun;13(5):439-44 |
12841566 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 EY014685 |
NEI NIH HHS |
United States |
| R01 EY018246 |
NEI NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Aged |
|
| Aged, 80 and over |
|
| Anterior Chamber |
anatomy & histology |
| Anthropometry |
methods |
| Biometry |
methods |
| Child |
methods |
| Child, Preschool |
methods |
| Cornea |
anatomy & histology |
| Eye |
anatomy & histology |
| Female |
anatomy & histology |
| Humans |
anatomy & histology |
| Infant, Newborn |
anatomy & histology |
| Intraocular Pressure |
anatomy & histology |
| Male |
anatomy & histology |
| Middle Aged |
anatomy & histology |
| Phenotype |
anatomy & histology |
| Pupil |
anatomy & histology |
| Retina |
anatomy & histology |
| Retinal Vessels |
anatomy & histology |
| Visual Acuity |
anatomy & histology |
| Young Adult |
anatomy & histology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
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| OTHER ID's |
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