Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21443290
TITLE
Disordered gambling as defined by the Diagnostic and Statistical Manual of Mental Disorders and the South Oaks Gambling Screen: evidence for a common etiologic structure.
ABSTRACT
In a previous article, we demonstrated in a large twin study that disordered gambling (DG), as defined by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV), ran in families, that about half of the variation in liability for DG was due to familial factors, and that all of this was explained by shared genetic rather than shared environmental influences (Slutske, Zhu, Meier, & Martin, 2010). The purpose of the present study is to extend this work to include an alternative conceptualization of DG that is provided by the South Oaks Gambling Screen (SOGS) item set in order to (a) compare the magnitude of the familial resemblance obtained when using the two definitions of DG (based on the DSM-IV and the SOGS), (b) examine the extent to which the 2 definitions tap the same underlying sources of genetic and environmental variation, and (c) examine whether the same results will be obtained among men and women. The results of bivariate twin model-fitting analyses suggested that DG, as defined by the DSM-IV and the SOGS, substantially overlapped at the etiologic level among both men and women, which supports the construct validity of both the DSM and the SOGS conceptualizations of DG. This study highlights the utility of twin studies for appraising the validity of the diagnostic nomenclature.
2011 American Psychological Association
DATE PUBLISHED
2011 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2011/03/30 06:00
pubmed 2011/03/30 06:00
medline 2011/12/14 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Slutske WS Slutske Wendy S WS Department of Psychological Sciences, 210 McAlester Hall, University of Missouri, Columbia, Missouri 65211, USA. slutskew@missouri.edu
Zhu G Zhu Gu G
Meier MH Meier Madeline H MH
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 120
ISSUE: 3
TITLE: Journal of abnormal psychology
ISOABBREVIATION: J Abnorm Psychol
YEAR: 2011
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1939-1846
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Abnorm Psychol
COUNTRY: United States
ISSNLINKING: 0021-843X
NLMUNIQUEID: 0034461
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
MH66206 NIMH NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
R01 MH066206-01A1 NIMH NIH HHS United States
R01 MH066206-02 NIMH NIH HHS United States
R01 MH066206-03 NIMH NIH HHS United States
R01 MH066206-04 NIMH NIH HHS United States
R01 MH066206-05 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Diagnostic and Statistical Manual of Mental Disorders
Diseases in Twins etiology
Disruptive, Impulse Control, and Conduct Disorders etiology
Female etiology
Gambling etiology
Humans etiology
Male etiology
Psychiatric Status Rating Scales etiology
Psychometrics etiology
Registries etiology
Social Environment etiology
Twins etiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS277569 NLM
PMC3144278 NLM