Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21356266
TITLE
Interactions between the COMT Val108/158Met polymorphism and maternal prenatal smoking predict aggressive behavior outcomes.
ABSTRACT
The purpose of the current study is to examine the moderating influence of the catechol O methyltransferase gene (COMT) on the maternal prenatal smoking/offspring externalizing disorder relationship. The sample consisted of 430 young adults born between 1981 and 1984 at the Mater Misericordiae Mother's Hospital in Brisbane, Australia, as well as their mothers and peers. Mothers reported their prenatal smoking status during pregnancy, and genetic data was obtained from the youth at a later follow-up in adulthood. The outcome measures in this study were mother and teacher reports of youth attention problems and aggression at age 15, and youth, mother and peer reports of youth attention problems and aggression at age 20 (combined to create latent factors of attention problems and aggression at each age). The COMT Val108/158Met polymorphism (rs4680) significantly interacted with maternal cigarette smoking during pregnancy to predict youth aggressive behavior at ages 15 and 20. This gene-environment interaction was not significant for youth attention problems.
Copyright © 2011 Elsevier B.V. All rights reserved.
DATE PUBLISHED
2011 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2010/11/04
revised 2011/01/20
accepted 2011/02/19
aheadofprint 2011/02/26
entrez 2011/03/02 06:00
pubmed 2011/03/02 06:00
medline 2011/08/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Brennan PA Brennan Patricia A PA Department of Psychology, 36 Eagle Row, Emory University, Atlanta, GA 30322, USA. pbren01@emory.edu
Hammen C Hammen Constance C
Sylvers P Sylvers Patrick P
Bor W Bor William W
Najman J Najman Jake J
Lind P Lind Penelope P
Montgomery G Montgomery Grant G
Smith AK Smith Alicia K AK
INVESTIGATORS
JOURNAL
VOLUME: 87
ISSUE: 1
TITLE: Biological psychology
ISOABBREVIATION: Biol Psychol
YEAR: 2011
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1873-6246
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Biol Psychol
COUNTRY: Netherlands
ISSNLINKING: 0301-0511
NLMUNIQUEID: 0375566
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 MH052239 NIMH NIH HHS United States
R01 MH052239-10 NIMH NIH HHS United States
R01 MH52239 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Age Factors
Aggression physiology
Attention Deficit Disorder with Hyperactivity genetics
Catechol O-Methyltransferase genetics
Cohort Studies genetics
Female genetics
Humans genetics
Male genetics
Methionine genetics
Models, Biological genetics
Polymorphism, Single Nucleotide genetics
Pregnancy genetics
Prenatal Exposure Delayed Effects genetics
Smoking adverse effects
Valine genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
AE28F7PNPL Methionine
EC 2.1.1.6 Catechol O-Methyltransferase
HG18B9YRS7 Valine
OTHER ID's
OTHERID SOURCE
NIHMS285211 NLM
PMC3081881 NLM
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