|
|
| PMID |
|
|
| TITLE |
|
| Variance components models for physical activity with age as modifier: a comparative twin study in seven countries. |
|
| ABSTRACT |
|
|
|
| Physical activity is influenced by genetic factors whose expression may change with age. We employed an extension to the classical twin model that allows a modifier variable, age, to interact with the effects of the latent genetic and environmental factors. The model was applied to self-reported data from twins aged 19 to 50 from seven countries that collaborated in the GenomEUtwin project: Australia, Denmark, Finland, Norway, Netherlands, Sweden and United Kingdom. Results confirmed the importance of genetic influences on physical activity in all countries and showed an age-related decrease in heritability for 4 countries. In the other three countries age did not interact with heritability but those samples were smaller or had a more restricted age range. Effects of shared environment were absent, except in older Swedish participants. The study confirms the importance of taking age effects into account when exploring the genetic and environmental contribution to physical activity. It also suggests that the power of genome-wide association studies to identify the genetic variants contributing to physical activity may be larger in young adult cohorts. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2011/02/15 06:00 |
| pubmed |
2011/02/15 06:00 |
| medline |
2011/04/16 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Vink JM |
|
Vink |
Jacqueline M |
JM |
|
Department of Biological Psychology, VU University, the Netherlands. jm.vink@psy.vu.nl |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
|
| Medland SE |
|
Medland |
Sarah E |
SE |
|
|
| de Moor MH |
|
de Moor |
Marleen H M |
MH |
|
|
| Stubbe JH |
|
Stubbe |
Janine H |
JH |
|
|
| Cornes BK |
|
Cornes |
Belinda K |
BK |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Skytthea A |
|
Skytthea |
Axel |
A |
|
|
| Kyvik KO |
|
Kyvik |
Kirsten O |
KO |
|
|
| Rose RJ |
|
Rose |
Richard J |
RJ |
|
|
| Kujala UM |
|
Kujala |
Urho M |
UM |
|
|
| Kaprio J |
|
Kaprio |
Jaakko |
J |
|
|
| Harris JR |
|
Harris |
Jennifer R |
JR |
|
|
| Pedersen NL |
|
Pedersen |
Nancy L |
NL |
|
|
| Cherkas L |
|
Cherkas |
Lynn |
L |
|
|
| Spector TD |
|
Spector |
Tim D |
TD |
|
|
| de Geus EJ |
|
de Geus |
Eco J C |
EJ |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 14 |
| ISSUE: 1 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2011 |
| MONTH: Feb |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Comparative Study |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA013320 |
NIAAA NIH HHS |
United States |
| AA013326 |
NIAAA NIH HHS |
United States |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA08315 |
NIAAA NIH HHS |
United States |
| AA12502 |
NIAAA NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Age Factors |
|
| Australia |
|
| Cross-Cultural Comparison |
|
| Denmark |
|
| Environment |
|
| Female |
|
| Finland |
|
| Humans |
|
| Male |
|
| Middle Aged |
|
| Motor Activity |
|
| Netherlands |
|
| Norway |
|
| Self Report |
|
| Sweden |
|
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
| United Kingdom |
genetics |
| Young Adult |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
