Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21302343
TITLE
The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects.
ABSTRACT
Intelligence is a highly heritable trait for which it has proven difficult to identify the actual genes. In the past decade, five whole-genome linkage scans have suggested genomic regions important to human intelligence; however, so far none of the responsible genes or variants in those regions have been identified. Apart from these regions, a handful of candidate genes have been identified, although most of these are in need of replication. The recent growth in publicly available data sets that contain both whole genome association data and a wealth of phenotypic data, serves as an excellent resource for fine mapping and candidate gene replication. We used the publicly available data of 947 families participating in the International Multi-Centre ADHD Genetics (IMAGE) study to conduct an in silico fine mapping study of previously associated genomic locations, and to attempt replication of previously reported candidate genes for intelligence. Although this sample was ascertained for attention deficit/hyperactivity disorder (ADHD), intelligence quotient (IQ) scores were distributed normally. We tested 667 single nucleotide polymorphisms (SNPs) within 15 previously reported candidate genes for intelligence and 29451 SNPs in five genomic loci previously identified through whole genome linkage and association analyses. Significant SNPs were tested in four independent samples (4,357 subjects), one ascertained for ADHD, and three population-based samples. Associations between intelligence and SNPs in the ATXN1 and TRIM31 genes and in three genomic locations showed replicated association, but only in the samples ascertained for ADHD, suggesting that these genetic variants become particularly relevant to IQ on the background of a psychiatric disorder.
Copyright © 2010 Wiley-Liss, Inc.
DATE PUBLISHED
2011 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2009/05/27
accepted 2010/10/26
aheadofprint 2010/12/16
entrez 2011/02/09 06:00
pubmed 2011/02/09 06:00
medline 2011/05/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Rizzi TS Rizzi Thais S TS Department of Functional Genomics, CNCR, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam, the Netherlands. t.rizzi@vumc.nl
Arias-Vasquez A Arias-Vasquez Alejandro A
Rommelse N Rommelse Nanda N
Kuntsi J Kuntsi Jonna J
Anney R Anney Richard R
Asherson P Asherson Philip P
Buitelaar J Buitelaar Jan J
Banaschewski T Banaschewski Tobias T
Ebstein R Ebstein Richard R
Ruano D Ruano Dina D
Van der Sluis S Van der Sluis Sophie S
Markunas CA Markunas Christina A CA
Garrett ME Garrett Melanie E ME
Ashley-Koch AE Ashley-Koch Allison E AE
Kollins SH Kollins Scott H SH
Anastopoulos AD Anastopoulos Arthur D AD
Hansell NK Hansell Narelle K NK
Wright MJ Wright Margaret J MJ
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Harris SE Harris Sarah E SE
Davies G Davies Gail G
Tenesa A Tenesa Albert A
Porteous DJ Porteous David J DJ
Starr JM Starr John M JM
Deary IJ Deary Ian J IJ
St Pourcain B St Pourcain Beate B
Davey Smith G Davey Smith George G
Timpson NJ Timpson Nicholas J NJ
Evans DM Evans David M DM
Gill M Gill Michael M
Miranda A Miranda Ana A
Mulas F Mulas Fernando F
Oades RD Oades Robert D RD
Roeyers H Roeyers Herbert H
Rothenberger A Rothenberger Aribert A
Sergeant J Sergeant Joseph J
Sonuga-Barke E Sonuga-Barke Edmund E
Steinhausen HC Steinhausen Hans Christoph HC
Taylor E Taylor Eric E
Faraone SV Faraone Stephen V SV
Franke B Franke Barbara B
Posthuma D Posthuma Danielle D
INVESTIGATORS
JOURNAL
VOLUME: 156
ISSUE: 2
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2011
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
076467/Z05/z Wellcome Trust United Kingdom
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
CZB/4/505 Chief Scientist Office United Kingdom
ETM/55 Chief Scientist Office United Kingdom
G0300189 Medical Research Council United Kingdom
G03001896 Medical Research Council United Kingdom
G0600705 Medical Research Council United Kingdom
G0700704 Medical Research Council United Kingdom
G0800582 Medical Research Council United Kingdom
K24 DA023464 NIDA NIH HHS United States
MC_PC_15018 Medical Research Council United Kingdom
NS049067 NINDS NIH HHS United States
R01MH081803 NIMH NIH HHS United States
R01MH62873 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Ataxin-1
Ataxins
Attention Deficit Disorder with Hyperactivity psychology
Cohort Studies psychology
European Continental Ancestry Group statistics & numerical data
Humans statistics & numerical data
Intelligence genetics
Meta-Analysis as Topic genetics
Nerve Tissue Proteins genetics
Nuclear Family genetics
Nuclear Proteins genetics
Phenotype genetics
Polymorphism, Single Nucleotide genetics
Ubiquitin-Protein Ligases genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 ATXN1 protein, human
0 Ataxin-1
0 Ataxins
0 Nerve Tissue Proteins
0 Nuclear Proteins
EC 6.3.2.- TRIM31 protein, human
EC 6.3.2.19 Ubiquitin-Protein Ligases
OTHER ID's
OTHERID SOURCE
PMC3085124 NLM
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