Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21297633
TITLE
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
ABSTRACT
Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.
DATE PUBLISHED
2011 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2010/09/15
accepted 2011/01/14
aheadofprint 2011/02/06
entrez 2011/02/08 06:00
pubmed 2011/02/08 06:00
medline 2011/04/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Anderson CA Anderson Carl A CA Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Boucher G Boucher Gabrielle G
Lees CW Lees Charlie W CW
Franke A Franke Andre A
D'Amato M D'Amato Mauro M
Taylor KD Taylor Kent D KD
Lee JC Lee James C JC
Goyette P Goyette Philippe P
Imielinski M Imielinski Marcin M
Latiano A Latiano Anna A
Lagacé C Lagacé Caroline C
Scott R Scott Regan R
Amininejad L Amininejad Leila L
Bumpstead S Bumpstead Suzannah S
Baidoo L Baidoo Leonard L
Baldassano RN Baldassano Robert N RN
Barclay M Barclay Murray M
Bayless TM Bayless Theodore M TM
Brand S Brand Stephan S
Büning C Büning Carsten C
Colombel JF Colombel Jean-Frédéric JF
Denson LA Denson Lee A LA
De Vos M De Vos Martine M
Dubinsky M Dubinsky Marla M
Edwards C Edwards Cathryn C
Ellinghaus D Ellinghaus David D
Fehrmann RS Fehrmann Rudolf S N RS
Floyd JA Floyd James A B JA
Florin T Florin Timothy T
Franchimont D Franchimont Denis D
Franke L Franke Lude L
Georges M Georges Michel M
Glas J Glas Jürgen J
Glazer NL Glazer Nicole L NL
Guthery SL Guthery Stephen L SL
Haritunians T Haritunians Talin T
Hayward NK Hayward Nicholas K NK
Hugot JP Hugot Jean-Pierre JP
Jobin G Jobin Gilles G
Laukens D Laukens Debby D
Lawrance I Lawrance Ian I
Lémann M Lémann Marc M
Levine A Levine Arie A
Libioulle C Libioulle Cecile C
Louis E Louis Edouard E
McGovern DP McGovern Dermot P DP
Milla M Milla Monica M
Montgomery GW Montgomery Grant W GW
Morley KI Morley Katherine I KI
Mowat C Mowat Craig C
Ng A Ng Aylwin A
Newman W Newman William W
Ophoff RA Ophoff Roel A RA
Papi L Papi Laura L
Palmieri O Palmieri Orazio O
Peyrin-Biroulet L Peyrin-Biroulet Laurent L
Panés J Panés Julián J
Phillips A Phillips Anne A
Prescott NJ Prescott Natalie J NJ
Proctor DD Proctor Deborah D DD
Roberts R Roberts Rebecca R
Russell R Russell Richard R
Rutgeerts P Rutgeerts Paul P
Sanderson J Sanderson Jeremy J
Sans M Sans Miquel M
Schumm P Schumm Philip P
Seibold F Seibold Frank F
Sharma Y Sharma Yashoda Y
Simms LA Simms Lisa A LA
Seielstad M Seielstad Mark M
Steinhart AH Steinhart A Hillary AH
Targan SR Targan Stephan R SR
van den Berg LH van den Berg Leonard H LH
Vatn M Vatn Morten M
Verspaget H Verspaget Hein H
Walters T Walters Thomas T
Wijmenga C Wijmenga Cisca C
Wilson DC Wilson David C DC
Westra HJ Westra Harm-Jan HJ
Xavier RJ Xavier Ramnik J RJ
Zhao ZZ Zhao Zhen Z ZZ
Ponsioen CY Ponsioen Cyriel Y CY
Andersen V Andersen Vibeke V
Torkvist L Torkvist Leif L
Gazouli M Gazouli Maria M
Anagnou NP Anagnou Nicholas P NP
Karlsen TH Karlsen Tom H TH
Kupcinskas L Kupcinskas Limas L
Sventoraityte J Sventoraityte Jurgita J
Mansfield JC Mansfield John C JC
Kugathasan S Kugathasan Subra S
Silverberg MS Silverberg Mark S MS
Halfvarson J Halfvarson Jonas J
Rotter JI Rotter Jerome I JI
Mathew CG Mathew Christopher G CG
Griffiths AM Griffiths Anne M AM
Gearry R Gearry Richard R
Ahmad T Ahmad Tariq T
Brant SR Brant Steven R SR
Chamaillard M Chamaillard Mathias M
Satsangi J Satsangi Jack J
Cho JH Cho Judy H JH
Schreiber S Schreiber Stefan S
Daly MJ Daly Mark J MJ
Barrett JC Barrett Jeffrey C JC
Parkes M Parkes Miles M
Annese V Annese Vito V
Hakonarson H Hakonarson Hakon H
Radford-Smith G Radford-Smith Graham G
Duerr RH Duerr Richard H RH
Vermeire S Vermeire Séverine S
Weersma RK Weersma Rinse K RK
Rioux JD Rioux John D JD
INVESTIGATORS
JOURNAL
VOLUME: 43
ISSUE: 3
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2011
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
083948/Z/07/Z Wellcome Trust United Kingdom
AI062773 NIAID NIH HHS United States
CZB/4/540 Chief Scientist Office United Kingdom
DK 063491 NIDDK NIH HHS United States
DK043351 NIDDK NIH HHS United States
DK062413 NIDDK NIH HHS United States
DK062420 NIDDK NIH HHS United States
DK062422 NIDDK NIH HHS United States
DK062423 NIDDK NIH HHS United States
DK062429 NIDDK NIH HHS United States
DK062431 NIDDK NIH HHS United States
DK062432 NIDDK NIH HHS United States
DK064869 NIDDK NIH HHS United States
DK069513 NIDDK NIH HHS United States
DK076984 NIDDK NIH HHS United States
DK084554 NIDDK NIH HHS United States
DK83756 NIDDK NIH HHS United States
ETM/137 Chief Scientist Office United Kingdom
ETM/75 Chief Scientist Office United Kingdom
G0600329 Medical Research Council United Kingdom
G0800675 Medical Research Council United Kingdom
G0800759 Medical Research Council United Kingdom
G1002033 Medical Research Council United Kingdom
M01-RR00425 NCRR NIH HHS United States
P01 DK046763 NIDDK NIH HHS United States
P01-DK046763 NIDDK NIH HHS United States
P30 DK040561 NIDDK NIH HHS United States
P30 DK040561-15 NIDDK NIH HHS United States
P30 DK043351 NIDDK NIH HHS United States
R01 DK060049 NIDDK NIH HHS United States
R01 DK064869 NIDDK NIH HHS United States
R01 DK064869-05S1 NIDDK NIH HHS United States
R01 DK064869-06A1 NIDDK NIH HHS United States
R01 DK064869-07 NIDDK NIH HHS United States
R01 DK064869-08 NIDDK NIH HHS United States
R01 DK083756 NIDDK NIH HHS United States
U01 DK062420 NIDDK NIH HHS United States
U01 DK062431 NIDDK NIH HHS United States
U01 DK062432 NIDDK NIH HHS United States
U01 DK062432-07 NIDDK NIH HHS United States
U01 DK062432-08 NIDDK NIH HHS United States
U01 DK062432-09 NIDDK NIH HHS United States
U01 DK062432-10 NIDDK NIH HHS United States
UL1 TR000005 NCATS NIH HHS United States
WT089120/Z/09/Z Wellcome Trust United Kingdom
WT091745/Z/10/Z Wellcome Trust United Kingdom
Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Colitis, Ulcerative genetics
Crohn Disease genetics
Genome-Wide Association Study genetics
Humans genetics
Risk genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS265993 NLM
PMC3084597 NLM
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