Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21244438
TITLE
Alcoholic marriage: later start, sooner end.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Although associations between drinking behavior and marital status are well documented, timing of marital transitions as a function of alcohol use or disorder has received limited empirical attention.
METHODS NlmCategory: METHODS
We examine the relationship between lifetime history of alcohol dependence (AD) and timing and survival of first marriages in a sample of 3,575 female and 1,845 male adult Australian twins born mostly between 1940 and 1964. Survival analyses were conducted using Cox proportional hazards regression models.
RESULTS NlmCategory: RESULTS
Results indicate moderate delays in marriage associated with AD for both women and men. Among ever-married respondents, AD was strongly predictive of early separation, with similar effects observed for women and men. Heritable sources of covariation were also documented. For women, genetic influences shared between early-onset AD and marital timing were found. Genetic influences shared between AD and marital survival were observed for women without regard to onset and for men with later-onset AD.
CONCLUSIONS NlmCategory: CONCLUSIONS
Results confirm the importance of AD as a predictor of both timing and survival of first marriages, with genetic influences contributing to observed associations.
Copyright © 2011 by the Research Society on Alcoholism.
DATE PUBLISHED
2011 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2011/01/18
entrez 2011/01/20 06:00
pubmed 2011/01/20 06:00
medline 2011/12/14 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Waldron M Waldron Mary M Department of Counseling and Educational Psychology, School of Education, Indiana University, 201 N. Rose Avenue, Bloomington, IN 47405, USA. mwaldron@indiana.edu
Heath AC Heath Andrew C AC
Lynskey MT Lynskey Michael T MT
Bucholz KK Bucholz Kathleen K KK
Madden PA Madden Pamela A F PA
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 35
ISSUE: 4
TITLE: Alcoholism, clinical and experimental research
ISOABBREVIATION: Alcohol. Clin. Exp. Res.
YEAR: 2011
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1530-0277
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Alcohol Clin Exp Res
COUNTRY: England
ISSNLINKING: 0145-6008
NLMUNIQUEID: 7707242
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA15210 NIAAA NIH HHS United States
AA17688 NIAAA NIH HHS United States
DA023696 NIDA NIH HHS United States
HD52543 NICHD NIH HHS United States
K01 DA023696 NIDA NIH HHS United States
K01 DA023696-03 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
K05 AA017688-03 NIAAA NIH HHS United States
P60 AA011998 NIAAA NIH HHS United States
P60 AA011998-13 NIAAA NIH HHS United States
R01 AA015210 NIAAA NIH HHS United States
R01 AA015210-05 NIAAA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
R37 AA007728-20 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Alcohol Drinking psychology
Alcoholism psychology
Australia psychology
Behavior drug effects
Divorce statistics & numerical data
Female statistics & numerical data
Genetic Variation statistics & numerical data
Humans statistics & numerical data
Male statistics & numerical data
Marital Status statistics & numerical data
Marriage statistics & numerical data
Middle Aged statistics & numerical data
Proportional Hazards Models statistics & numerical data
Reproductive Behavior drug effects
Risk Factors drug effects
Surveys and Questionnaires drug effects
Time Factors drug effects
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS252306 NLM
PMC3066284 NLM
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