| PMID |
|
|
| TITLE |
|
| The contribution of genes to cortical thickness and volume. |
|
| ABSTRACT |
|
|
|
| We analyzed brain MRI data from 372 young adult twins to identify cortical regions in which gray matter thickness and volume are influenced by genetics. This was achieved using an A/C/E structural equation model that divides the variance of these traits, at each point on the cortex, into additive genetic (A), shared (C), and unique environmental (E) components. A strong genetic influence was found in frontal and parietal regions. In addition, we correlated cortical thickness with full-scale intelligence quotient for comparison with the A/C/E maps, and several regions where cortical structure was correlated with intelligence quotient are under genetic control. These cortical measures may be useful phenotypes to narrow the search for quantitative trait loci influencing brain structure. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2011/01/15 06:00 |
| pubmed |
2011/01/15 06:00 |
| medline |
2011/12/13 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Joshi AA |
|
Joshi |
Anand A |
AA |
|
Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, California, USA. |
| Leporé N |
|
Leporé |
Natasha |
N |
|
|
| Joshi SH |
|
Joshi |
Shantanu H |
SH |
|
|
| Lee AD |
|
Lee |
Agatha D |
AD |
|
|
| Barysheva M |
|
Barysheva |
Marina |
M |
|
|
| Stein JL |
|
Stein |
Jason L |
JL |
|
|
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
|
| Johnson K |
|
Johnson |
Kori |
K |
|
|
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
| Toga AW |
|
Toga |
Arthur W |
AW |
|
|
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 22 |
| ISSUE: 3 |
| TITLE: Neuroreport |
| ISOABBREVIATION: Neuroreport |
| YEAR: 2011 |
| MONTH: Feb |
| DAY: 16 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1473-558X |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Neuroreport |
| COUNTRY: England |
| ISSNLINKING: 0959-4965 |
| NLMUNIQUEID: 9100935 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Comparative Study |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
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20074649 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| P41 RR013642 |
NCRR NIH HHS |
United States |
| P41 RR013642 |
NCRR NIH HHS |
United States |
| P41 RR013642-05 |
NCRR NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| U54 RR021813 |
NCRR NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Brain Mapping |
methods |
| Cerebral Cortex |
growth & development |
| Female |
growth & development |
| Gene Expression Regulation, Developmental |
genetics |
| Humans |
genetics |
| Magnetic Resonance Imaging |
methods |
| Male |
methods |
| Models, Genetic |
methods |
| Quantitative Trait Loci |
genetics |
| Reaction Time |
genetics |
| Young Adult |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
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| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS259954 |
NLM |
| PMC3079384 |
NLM |
|
