Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21233781
TITLE
The contribution of genes to cortical thickness and volume.
ABSTRACT
We analyzed brain MRI data from 372 young adult twins to identify cortical regions in which gray matter thickness and volume are influenced by genetics. This was achieved using an A/C/E structural equation model that divides the variance of these traits, at each point on the cortex, into additive genetic (A), shared (C), and unique environmental (E) components. A strong genetic influence was found in frontal and parietal regions. In addition, we correlated cortical thickness with full-scale intelligence quotient for comparison with the A/C/E maps, and several regions where cortical structure was correlated with intelligence quotient are under genetic control. These cortical measures may be useful phenotypes to narrow the search for quantitative trait loci influencing brain structure.
DATE PUBLISHED
2011 Feb 16
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2011/01/15 06:00
pubmed 2011/01/15 06:00
medline 2011/12/13 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Joshi AA Joshi Anand A AA Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, California, USA.
Leporé N Leporé Natasha N
Joshi SH Joshi Shantanu H SH
Lee AD Lee Agatha D AD
Barysheva M Barysheva Marina M
Stein JL Stein Jason L JL
McMahon KL McMahon Katie L KL
Johnson K Johnson Kori K
de Zubicaray GI de Zubicaray Greig I GI
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Toga AW Toga Arthur W AW
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME: 22
ISSUE: 3
TITLE: Neuroreport
ISOABBREVIATION: Neuroreport
YEAR: 2011
MONTH: Feb
DAY: 16
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1473-558X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroreport
COUNTRY: England
ISSNLINKING: 0959-4965
NLMUNIQUEID: 9100935
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Neuroimage. 2010 Nov 15;53(3):1135-46 20006715
Cites Curr Opin Neurol. 2010 Aug;23(4):368-73 20581684
Cites Hum Brain Mapp. 2002 Jan;15(1):1-25 11747097
Cites Nat Neurosci. 2001 Dec;4(12):1253-8 11694885
Cites Hippocampus. 2001;11(6):754-62 11811670
Cites Nat Neurosci. 2002 Feb;5(2):83-4 11818967
Cites Neuroimage. 2002 Oct;17(2):825-41 12377157
Cites J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205 8126267
Cites Brain. 1997 Feb;120 ( Pt 2):257-69 9117373
Cites Neuroimage. 1999 Feb;9(2):179-94 9931268
Cites Neuroimage. 2005 Jan 1;24(1):163-73 15588607
Cites Neuroimage. 2006 Jul 1;31(3):968-80 16530430
Cites Hum Brain Mapp. 2009 Jan;30(1):163-74 18041741
Cites J Neurosci. 2009 Feb 18;29(7):2212-24 19228974
Cites Cereb Cortex. 2009 Nov;19(11):2728-35 19299253
Cites Neuroimage. 2010 Jan 15;49(2):1213-23 19786105
Cites Med Image Comput Comput Assist Interv. 2009;12(Pt 1):967-74 20426082
Cites Neuroimage. 2010 Nov 15;53(3):1117-25 20074649
GRANTS
GRANTID AGENCY COUNTRY
P41 RR013642 NCRR NIH HHS United States
P41 RR013642 NCRR NIH HHS United States
P41 RR013642-05 NCRR NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
U54 RR021813 NCRR NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Brain Mapping methods
Cerebral Cortex growth & development
Female growth & development
Gene Expression Regulation, Developmental genetics
Humans genetics
Magnetic Resonance Imaging methods
Male methods
Models, Genetic methods
Quantitative Trait Loci genetics
Reaction Time genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS259954 NLM
PMC3079384 NLM