Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21195196
TITLE
BDNF gene effects on brain circuitry replicated in 455 twins.
ABSTRACT
Brain-derived neurotrophic factor (BDNF) plays a key role in learning and memory, but its effects on the fiber architecture of the living brain are unknown. We genotyped 455 healthy adult twins and their non-twin siblings (188 males/267 females; age: 23.7±2.1 years, mean±SD) and scanned them with high angular resolution diffusion tensor imaging (DTI), to assess how the BDNF Val66Met polymorphism affects white matter microstructure. By applying genetic association analysis to every 3D point in the brain images, we found that the Val-BDNF genetic variant was associated with lower white matter integrity in the splenium of the corpus callosum, left optic radiation, inferior fronto-occipital fasciculus, and superior corona radiata. Normal BDNF variation influenced the association between subjects' performance intellectual ability (as measured by Object Assembly subtest) and fiber integrity (as measured by fractional anisotropy; FA) in the callosal splenium, and pons. BDNF gene may affect the intellectual performance by modulating the white matter development. This combination of genetic association analysis and large-scale diffusion imaging directly relates a specific gene to the fiber microstructure of the living brain and to human intelligence.
Copyright 2010 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2011 Mar 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2010/09/02
revised 2010/11/24
accepted 2010/12/20
aheadofprint 2010/12/30
entrez 2011/01/04 06:00
pubmed 2011/01/05 06:00
medline 2011/06/11 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Chiang MC Chiang Ming-Chang MC Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-7332, USA.
Barysheva M Barysheva Marina M
Toga AW Toga Arthur W AW
Medland SE Medland Sarah E SE
Hansell NK Hansell Narelle K NK
James MR James Michael R MR
McMahon KL McMahon Katie L KL
de Zubicaray GI de Zubicaray Greig I GI
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME: 55
ISSUE: 2
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2011
MONTH: Mar
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 HD050735 NICHD NIH HHS United States
R01 HD050735-04 NICHD NIH HHS United States
U54 RR021813 NCRR NIH HHS United States
U54 RR021813-05 NCRR NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Anisotropy
Brain anatomy & histology
Brain-Derived Neurotrophic Factor genetics
Diffusion Tensor Imaging genetics
Female genetics
Genome-Wide Association Study genetics
Humans genetics
Image Interpretation, Computer-Assisted genetics
Intelligence genetics
Male genetics
Polymorphism, Single Nucleotide genetics
Twins genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Brain-Derived Neurotrophic Factor
OTHER ID's
OTHERID SOURCE
NIHMS261879 NLM
PMC3192852 NLM