Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21173776
TITLE
Meta-analysis of genome-wide association studies for personality.
ABSTRACT
Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17,375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ≈ 2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P=2.8 × 10(-8) and 3.1 × 10(-8)) and for Conscientiousness in the brain-expressed KATNAL2 gene on 18q21.1 (rs2576037, P=4.9 × 10(-8)). We further conducted a gene-based test that confirmed the association of KATNAL2 to Conscientiousness. In silico replication did not, however, show significant associations of the top SNPs with Openness and Conscientiousness, although the direction of effect of the KATNAL2 SNP on Conscientiousness was consistent in all replication samples. Larger scale GWA studies and alternative approaches are required for confirmation of KATNAL2 as a novel gene affecting Conscientiousness.
DATE PUBLISHED
2012 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2010/12/21
entrez 2010/12/22 06:00
pubmed 2010/12/22 06:00
medline 2012/06/30 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
de Moor MH de Moor M H M MH Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. mhm.de.moor@psy.vu.nl
Costa PT Costa P T PT
Terracciano A Terracciano A A
Krueger RF Krueger R F RF
de Geus EJ de Geus E J C EJ
Toshiko T Toshiko T T
Penninx BW Penninx B W J H BW
Esko T Esko T T
Madden PA Madden P A F PA
Derringer J Derringer J J
Amin N Amin N N
Willemsen G Willemsen G G
Hottenga JJ Hottenga J-J JJ
Distel MA Distel M A MA
Uda M Uda M M
Sanna S Sanna S S
Spinhoven P Spinhoven P P
Hartman CA Hartman C A CA
Sullivan P Sullivan P P
Realo A Realo A A
Allik J Allik J J
Heath AC Heath A C AC
Pergadia ML Pergadia M L ML
Agrawal A Agrawal A A
Lin P Lin P P
Grucza R Grucza R R
Nutile T Nutile T T
Ciullo M Ciullo M M
Rujescu D Rujescu D D
Giegling I Giegling I I
Konte B Konte B B
Widen E Widen E E
Cousminer DL Cousminer D L DL
Eriksson JG Eriksson J G JG
Palotie A Palotie A A
Peltonen L Peltonen L L
Luciano M Luciano M M
Tenesa A Tenesa A A
Davies G Davies G G
Lopez LM Lopez L M LM
Hansell NK Hansell N K NK
Medland SE Medland S E SE
Ferrucci L Ferrucci L L
Schlessinger D Schlessinger D D
Montgomery GW Montgomery G W GW
Wright MJ Wright M J MJ
Aulchenko YS Aulchenko Y S YS
Janssens AC Janssens A C J W AC
Oostra BA Oostra B A BA
Metspalu A Metspalu A A
Abecasis GR Abecasis G R GR
Deary IJ Deary I J IJ
Räikkönen K Räikkönen K K
Bierut LJ Bierut L J LJ
Martin NG Martin N G NG
van Duijn CM van Duijn C M CM
Boomsma DI Boomsma D I DI
INVESTIGATORS
JOURNAL
VOLUME: 17
ISSUE: 3
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2012
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
089061 Wellcome Trust United Kingdom
089062 Wellcome Trust United Kingdom
089062/Z/09/Z Wellcome Trust United Kingdom
89061/Z/09/Z Wellcome Trust United Kingdom
AA07580 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
CA89392 NCI NIH HHS United States
DA019951 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
G0700704 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
MH081802 NIMH NIH HHS United States
N01 AG012109 NIA NIH HHS United States
N01-AG-1-2109 NIA NIH HHS United States
P01 CA089392 NCI NIH HHS United States
P01 CA089392 NCI NIH HHS United States
P01 CA089392-08 NCI NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA013423 NIDA NIH HHS United States
R01 DA013423 NIDA NIH HHS United States
R01 DA013423-05 NIDA NIH HHS United States
R01 DA019963 NIDA NIH HHS United States
R01 DA019963-01A2 NIDA NIH HHS United States
R01 DA019963-02 NIDA NIH HHS United States
R01 DA019963-03 NIDA NIH HHS United States
R01 MH059160 NIMH NIH HHS United States
U01 HG004422 NHGRI NIH HHS United States
U01 HG004422 NHGRI NIH HHS United States
U01 HG004422-02 NHGRI NIH HHS United States
U01 HG004446 NHGRI NIH HHS United States
U01HG004438 NHGRI NIH HHS United States
U10 AA008401 NIAAA NIH HHS United States
U10AA008401 NIAAA NIH HHS United States
Z99 AG999999 Intramural NIH HHS United States
ZIA AG000180-25 Intramural NIH HHS United States
ZIA AG000180-26 Intramural NIH HHS United States
ZIA AG000196-03 Intramural NIH HHS United States
ZIA AG000196-04 Intramural NIH HHS United States
ZIA AG000197-03 Intramural NIH HHS United States
ZIA AG000197-04 Intramural NIH HHS United States
Biotechnology and Biological Sciences Research Council United Kingdom
Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adenosine Triphosphatases physiology
Adult physiology
Aged physiology
Australia physiology
Chromosomes, Human genetics
Computer Simulation genetics
Europe ethnology
European Continental Ancestry Group genetics
Exploratory Behavior genetics
Female genetics
Genome-Wide Association Study genetics
Genotype genetics
Humans genetics
Male genetics
Middle Aged genetics
Models, Psychological genetics
Personality genetics
Personality Inventory genetics
Phenotype genetics
Polymorphism, Single Nucleotide genetics
Sampling Studies genetics
United States genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 3.6.1.- Adenosine Triphosphatases
EC 3.6.1.- KATNAL2 protein, human
OTHER ID's
OTHERID SOURCE
EMS54530 NLM
PMC3785122 NLM