Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
21156270
TITLE
Cognitive function in adolescence: testing for interactions between breast-feeding and FADS2 polymorphisms.
ABSTRACT
OBJECTIVES NlmCategory: OBJECTIVE
Breast-fed C-allele carriers of the rs174575 single nucleotide polymorphism in the fatty acyl desaturase 2 (FADS2) gene have been reported to show a 6.4 to 7 IQ point advantage over formula-fed C-allele carriers, with no effect of breast-feeding in GG carriers. An Australian sample was examined to determine if an interaction between breast-feeding and the rs174575 single nucleotide polymorphism had any effect on IQ.
METHOD NlmCategory: METHODS
This hypothesis was tested in more than 700 families of adolescent twins assessed for IQ and breast-feeding, birth weight, and FADS2 polymorphisms, and parental socioeconomic status and education, and maternal FADS2 status.
RESULTS NlmCategory: RESULTS
No significant evidence for a moderating effect on IQ of rs174575 C-carrier status and breast-feeding was found, and there no effects of maternal FADS2 status on offspring IQ. In addition, no main effects of any FADS2 polymorphisms on IQ were found when the genotype was kept as two-homozygote and one-heterozygote categories and indeed no evidence for effects of breast-feeding on IQ scores after controlling for parental socioeconomic status and education. The investigation was extended to two additional FADS2 polymorphisms (rs1535 and rs174583), but again, although these polymorphisms code alleles affecting fatty acid metabolism, no main or interaction effects were found on IQ.
CONCLUSION NlmCategory: CONCLUSIONS
These results support the view that apparent effects of breast-feeding on IQ reflect differential likelihood of breast-feeding as a function of parental education and did not support the predicted interaction effect of FADS2 and breast-feeding on IQ.
Copyright 2011 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
DATE PUBLISHED
2011 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2010/06/03
revised 2010/10/17
accepted 2010/10/20
aheadofprint 2010/12/03
entrez 2010/12/16 06:00
pubmed 2010/12/16 06:00
medline 2011/04/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Martin NW Martin Nicolas W NW Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia. nico.martin@qimr.edu.au
Benyamin B Benyamin Beben B
Hansell NK Hansell Narelle K NK
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Bates TC Bates Timothy C TC
INVESTIGATORS
JOURNAL
VOLUME: 50
ISSUE: 1
TITLE: Journal of the American Academy of Child and Adolescent Psychiatry
ISOABBREVIATION: J Am Acad Child Adolesc Psychiatry
YEAR: 2011
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1527-5418
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Am Acad Child Adolesc Psychiatry
COUNTRY: United States
ISSNLINKING: 0890-8567
NLMUNIQUEID: 8704565
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
Chief Scientist Office United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Australia
Breast Feeding psychology
Cognition physiology
Environment physiology
Family psychology
Fatty Acid Desaturases physiology
Female physiology
Heterozygote Detection physiology
Humans physiology
Intelligence Tests physiology
Male physiology
Mental Competency psychology
Polymorphism, Single Nucleotide psychology
Socioeconomic Factors psychology
Young Adult psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 1.14.19.- Fatty Acid Desaturases
EC 1.14.19.3 FADS2 protein, human
OTHER ID's