Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
21130836
TITLE
Whole genome association scan for genetic polymorphisms influencing information processing speed.
ABSTRACT
Processing speed is an important cognitive function that is compromised in psychiatric illness (e.g., schizophrenia, depression) and old age; it shares genetic background with complex cognition (e.g., working memory, reasoning). To find genes influencing speed we performed a genome-wide association scan in up to three cohorts: Brisbane (mean age 16 years; N = 1659); LBC1936 (mean age 70 years, N = 992); LBC1921 (mean age 82 years, N = 307), and; HBCS (mean age 64 years, N =1080). Meta-analysis of the common measures highlighted various suggestively significant (p < 1.21 × 10⁻⁵) SNPs and plausible candidate genes (e.g., TRIB3). A biological pathways analysis of the speed factor identified two common pathways from the KEGG database (cell junction, focal adhesion) in two cohorts, while a pathway analysis linked to the GO database revealed common pathways across pairs of speed measures (e.g., receptor binding, cellular metabolic process). These highlighted genes and pathways will be able to inform future research, including results for psychiatric disease.
Copyright 2010 Elsevier B.V. All rights reserved.
DATE PUBLISHED
2011 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2010/07/05
revised 2010/11/19
accepted 2010/11/25
aheadofprint 2010/12/03
entrez 2010/12/07 06:00
pubmed 2010/12/07 06:00
medline 2011/07/02 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Luciano M Luciano Michelle M Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Scotland, UK. michelle.luciano@ed.ac.uk
Hansell NK Hansell Narelle K NK
Lahti J Lahti Jari J
Davies G Davies Gail G
Medland SE Medland Sarah E SE
Räikkönen K Räikkönen Katri K
Tenesa A Tenesa Albert A
Widen E Widen Elisabeth E
McGhee KA McGhee Kevin A KA
Palotie A Palotie Aarno A
Liewald D Liewald David D
Porteous DJ Porteous David J DJ
Starr JM Starr John M JM
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Eriksson JG Eriksson Johan G JG
Wright MJ Wright Margaret J MJ
Deary IJ Deary Ian J IJ
INVESTIGATORS
JOURNAL
VOLUME: 86
ISSUE: 3
TITLE: Biological psychology
ISOABBREVIATION: Biol Psychol
YEAR: 2011
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1873-6246
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Biol Psychol
COUNTRY: Netherlands
ISSNLINKING: 0301-0511
NLMUNIQUEID: 0375566
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Gene. 2009 Sep 1;444(1-2):24-32 19505541
Cites Am J Hum Genet. 2009 Jul;85(1):13-24 19539887
Cites Addiction. 2009 Sep;104(9):1558-68 19686526
Cites Br J Sports Med. 2001 Oct;35(5):297-302 11579059
Cites Twin Res. 2001 Feb;4(1):48-56 11665325
Cites Behav Genet. 2001 Nov;31(6):593-602 11838536
Cites Life Sci. 2002 Feb 15;70(13):1555-64 11895106
Cites J Neurosci Res. 2002 Jul 15;69(2):243-56 12111806
Cites J Neurol Neurosurg Psychiatry. 2002 Sep;73(3):261-6 12185156
Cites Neurology. 2002 Oct 8;59(7):1042-6 12370459
Cites Am J Hum Genet. 2003 Feb;72(2):303-12 12509789
Cites Clin J Sport Med. 2003 Jan;13(1):28-32 12544161
Cites J Pers Soc Psychol. 2004 Jan;86(1):130-47 14717632
Cites Behav Genet. 2004 Jan;34(1):41-50 14739695
Cites Psychol Sci. 2009 Sep;20(9):1146-52 19686293
Cites Bioinformatics. 2009 Oct 15;25(20):2762-3 19620097
Cites Am J Hum Genet. 2009 Nov;85(5):750-5 19896111
Cites Neuropsychology. 2010 Jan;24(1):109-20 20063952
Cites Psychol Aging. 2010 Mar;25(1):219-28 20230141
Cites Hum Mol Genet. 2010 Jun 1;19(11):2321-30 20197412
Cites Eur J Hum Genet. 2010 Jun;18(6):668-73 20068590
Cites Diabetologia. 2010 Jul;53(7):1354-61 20393693
Cites Eur J Hum Genet. 2010 Jul;18(7):815-20 20125193
Cites Nat Genet. 2010 Jul;42(7):565-9 20562875
Cites J Affect Disord. 2010 Sep;125(1-3):155-64 20085849
Cites Neuroimage. 2004 Aug;22(4):1466-79 15275904
Cites Percept Psychophys. 1980 Oct;28(4):377-9 7465322
Cites Behav Genet. 1988 Mar;18(2):247-61 3377737
Cites Behav Genet. 1991 Jul;21(4):351-67 1953598
Cites Virchows Arch. 1994;424(4):421-7 7515758
Cites Psychol Rev. 1996 Jul;103(3):403-28 8759042
Cites Neurosci Lett. 1998 Jan 9;240(2):97-101 9486481
Cites Behav Brain Res. 1998 Sep;95(1):77-84 9754879
Cites Genet Epidemiol. 1999;16(1):40-53 9915566
Cites Psychol Sci. 2005 Jan;16(1):64-9 15660853
Cites Biol Psychol. 2005 Sep;70(1):1-8 16038769
Cites N Engl J Med. 2005 Oct 27;353(17):1802-9 16251536
Cites Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17053-8 16278297
Cites Am J Hum Genet. 2006 Jan;78(1):52-62 16385449
Cites Psychol Aging. 2006 Mar;21(1):62-73 16594792
Cites Immunol Lett. 2006 Jun 15;105(2):193-7 16644022
Cites Diabetologia. 2006 Dec;49(12):2853-8 17096117
Cites BMC Genet. 2007;8:43 17601350
Cites Mol Immunol. 2008 Jan;45(1):283-8 17544510
Cites Hum Mol Genet. 2007 Dec 15;16(24):3027-36 17855452
Cites Psychoneuroendocrinology. 2008 Jan;33(1):68-76 17988804
Cites BMC Geriatr. 2007;7:28 18053258
Cites Psychosom Med. 2008 Apr;70(3):306-13 18378874
Cites Genes Brain Behav. 2008 Jun;7(4):411-7 17973920
Cites J Clin Endocrinol Metab. 2009 Jan;94(1):190-6 18984671
Cites BMC Genomics. 2008;9:516 18976480
Cites Diabetes Res Clin Pract. 2009 Mar;83(3):379-86 19167774
Cites Dement Geriatr Cogn Disord. 2009;27(1):59-68 19141999
Cites J Hum Genet. 2009 Feb;54(2):108-14 19165231
Cites Psychol Aging. 2009 Mar;24(1):129-38 19290744
Cites Dev Psychol. 2009 May;45(3):820-34 19413434
Cites Ann Dyslexia. 2009 Jun;59(1):1-11 19238550
Cites Diabetes Care. 2009 Jul;32(7):1311-3 19389818
Cites Biol Psychiatry. 2009 Aug 15;66(4):368-75 19362708
GRANTS
GRANTID AGENCY COUNTRY
089062 Wellcome Trust United Kingdom
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
CZB/4/505 Chief Scientist Office United Kingdom
ETM/55 Chief Scientist Office United Kingdom
G0700704 Medical Research Council United Kingdom
WT089062 Wellcome Trust United Kingdom
Biotechnology and Biological Sciences Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adaptor Proteins, Signal Transducing genetics
Adolescent genetics
Age Factors genetics
Aged genetics
Aged, 80 and over genetics
Cohort Studies genetics
Databases, Genetic statistics & numerical data
Female statistics & numerical data
Genome-Wide Association Study methods
Humans methods
International Cooperation methods
Keratins genetics
Male genetics
Mental Processes physiology
Meta-Analysis as Topic physiology
Neuropsychological Tests physiology
Polymorphism, Genetic physiology
Sex Factors physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Adaptor Proteins, Signal Transducing
68238-35-7 Keratins
OTHER ID's
OTHERID SOURCE
PMC3319015 NLM
UKMS47308 NLM