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PMID |
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TITLE |
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Relationship between type 1 diabetes and atopic diseases in a twin population. |
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ABSTRACT |
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AIM |
NlmCategory: OBJECTIVE |
To study the association between type 1 diabetes and atopic diseases in a twin population. |
METHODS |
NlmCategory: METHODS |
We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age. |
RESULTS |
NlmCategory: RESULTS |
The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009. |
CONCLUSIONS |
NlmCategory: CONCLUSIONS |
These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders. |
© 2010 John Wiley & Sons A/S. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
aheadofprint |
2010/12/01 |
entrez |
2010/12/03 06:00 |
pubmed |
2010/12/03 06:00 |
medline |
2011/08/09 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Thomsen SF |
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Thomsen |
S F |
SF |
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Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark. sft@city.dk |
Duffy DL |
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Duffy |
D L |
DL |
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Kyvik KO |
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Kyvik |
K O |
KO |
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Skytthe A |
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Skytthe |
A |
A |
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Backer V |
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Backer |
V |
V |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 66 |
ISSUE: 5 |
TITLE: Allergy |
ISOABBREVIATION: Allergy |
YEAR: 2011 |
MONTH: May |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1398-9995 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Allergy |
COUNTRY: Denmark |
ISSNLINKING: 0105-4538 |
NLMUNIQUEID: 7804028 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, Non-U.S. Gov't |
Twin Study |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
CommentIn |
Allergy. 2011 Dec;66(12):1612-3; author reply 1613-4 |
21797884 |
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GRANTS |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adolescent |
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Adult |
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Aged |
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Asthma |
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Child |
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Child, Preschool |
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Dermatitis, Atopic |
etiology |
Diabetes Mellitus, Type 1 |
genetics |
Female |
genetics |
Humans |
genetics |
Male |
genetics |
Middle Aged |
genetics |
Odds Ratio |
genetics |
Rhinitis, Allergic, Seasonal |
genetics |
Th1 Cells |
genetics |
Th2 Cells |
genetics |
Twins |
genetics |
Young Adult |
genetics |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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