|
|
| PMID |
|
|
| TITLE |
|
| Relationship between type 1 diabetes and atopic diseases in a twin population. |
|
| ABSTRACT |
|
| AIM |
NlmCategory: OBJECTIVE |
| To study the association between type 1 diabetes and atopic diseases in a twin population. |
| METHODS |
NlmCategory: METHODS |
| We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age. |
| RESULTS |
NlmCategory: RESULTS |
| The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders. |
| © 2010 John Wiley & Sons A/S. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2010/12/01 |
| entrez |
2010/12/03 06:00 |
| pubmed |
2010/12/03 06:00 |
| medline |
2011/08/09 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Thomsen SF |
|
Thomsen |
S F |
SF |
|
Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark. sft@city.dk |
| Duffy DL |
|
Duffy |
D L |
DL |
|
|
| Kyvik KO |
|
Kyvik |
K O |
KO |
|
|
| Skytthe A |
|
Skytthe |
A |
A |
|
|
| Backer V |
|
Backer |
V |
V |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 66 |
| ISSUE: 5 |
| TITLE: Allergy |
| ISOABBREVIATION: Allergy |
| YEAR: 2011 |
| MONTH: May |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1398-9995 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Allergy |
| COUNTRY: Denmark |
| ISSNLINKING: 0105-4538 |
| NLMUNIQUEID: 7804028 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| CommentIn |
Allergy. 2011 Dec;66(12):1612-3; author reply 1613-4 |
21797884 |
|
|
| GRANTS |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Aged |
|
| Asthma |
|
| Child |
|
| Child, Preschool |
|
| Dermatitis, Atopic |
etiology |
| Diabetes Mellitus, Type 1 |
genetics |
| Female |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Odds Ratio |
genetics |
| Rhinitis, Allergic, Seasonal |
genetics |
| Th1 Cells |
genetics |
| Th2 Cells |
genetics |
| Twins |
genetics |
| Young Adult |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
