|
|
| PMID |
|
|
| TITLE |
|
| Risk of asthma in adult twins with type 2 diabetes and increased body mass index. |
|
| ABSTRACT |
|
| AIM |
NlmCategory: OBJECTIVE |
| To examine the relationship between asthma, type 2 diabetes and increased body mass index (BMI) in adult twins. |
| METHODS |
NlmCategory: METHODS |
| We performed record linkage between questionnaire-defined asthma and BMI, and hospital discharge diagnoses of type 2 diabetes in 34,782 Danish twins, 20-71 years of age. |
| RESULTS |
NlmCategory: RESULTS |
| The risk of asthma was increased in subjects with type 2 diabetes relative to nondiabetic subjects both in men (13.5%vs 7.5%), P = 0.001 and in women (16.6%vs 9.6%), P = 0.001. The result remained significant after adjustment for age, BMI, smoking, symptoms of chronic bronchitis, marital status and zygosity, men: OR = 1.70 (1.07-2.70), P = 0.026; women: OR = 1.88 (1.24-2.85), P = 0.003. In this analysis, BMI remained a highly significant predictor for asthma independently of diabetes status in women, P < 0.000 but not in men, P = 0.336. Significant positive genetic correlations were found between asthma and type 2 diabetes, 0.20 (0.01-0.40), P = 0.047; between asthma and BMI in women, 0.15 (0.07-0.22), P < 0.000; and between BMI and type 2 diabetes, 0.40 (0.29-0.43), P < 0.000. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Asthma, type 2 diabetes and increased BMI are strongly associated in adults, particularly in women. These results suggest a common aetiology for asthma and metabolic syndrome. |
| © 2010 John Wiley & Sons A/S. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2010/11/17 |
| entrez |
2010/11/19 06:00 |
| pubmed |
2010/11/19 06:00 |
| medline |
2011/07/21 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Thomsen SF |
|
Thomsen |
S F |
SF |
|
Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark. sft@city.dk |
| Duffy DL |
|
Duffy |
D L |
DL |
|
|
| Kyvik KO |
|
Kyvik |
K O |
KO |
|
|
| Skytthe A |
|
Skytthe |
A |
A |
|
|
| Backer V |
|
Backer |
V |
V |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 66 |
| ISSUE: 4 |
| TITLE: Allergy |
| ISOABBREVIATION: Allergy |
| YEAR: 2011 |
| MONTH: Apr |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1398-9995 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Allergy |
| COUNTRY: Denmark |
| ISSNLINKING: 0105-4538 |
| NLMUNIQUEID: 7804028 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
|
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| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Asthma |
etiology |
| Body Mass Index |
etiology |
| Diabetes Mellitus, Type 2 |
complications |
| Diseases in Twins |
immunology |
| Female |
immunology |
| Humans |
immunology |
| Male |
immunology |
| Middle Aged |
immunology |
| Risk Factors |
immunology |
| Twins |
immunology |
| Young Adult |
immunology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
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