Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
20970773
TITLE
Associations of birth weight with ocular biometry, refraction, and glaucomatous endophenotypes: the Australian Twins Eye Study.
ABSTRACT
PURPOSE NlmCategory: OBJECTIVE
To examine the relationship of birth weight with ocular measures in a Caucasian twin population.
DESIGN NlmCategory: METHODS
Cross-sectional study of 1498 twins (308 monozygotic and 441 dizygotic pairs) aged between 5 to 80 years participating in the Australian Twins Eye Study.
METHODS NlmCategory: METHODS
All participants underwent ophthalmic examination including bilateral cycloplegic autorefraction, keratometry, interpupillary distance (IPD), central corneal thickness, intraocular pressure (IOP), and retinal photography. Birth weight and gestation were obtained from a self-administered questionnaire. A subset of the twins also participated in the Tasmanian Infant Health Study (288) and the Childhood Blood Pressure Study (184), which collected data on birth parameters allowing for verification of data. Linear mixed models were used for the main analysis.
RESULTS NlmCategory: RESULTS
Both the within-pair (β(w) 0.27, 95% confidence interval [CI] 0.15, 0.38 mm per kg increase in birth weight, P < .001) and between-pair associations (β(B) 0.22, 95% CI 0.08, 0.35, P = .002) of birth weight with axial length were significant and of similar magnitude (difference in effect, P = .56), after adjusting for relevant confounders. In contrast, birth weight was negatively associated with corneal curvature (β(w) -0.82, 95% CI -1.09, -0.55 diopters per kg increase; β(B) -0.69, 95% CI -0.98, -0.41, both P < .001). These associations remained significant within dizygotic and monozygotic pairs. Refraction, anterior chamber depth, IPD, IOP, and optic disc parameters are unrelated to birth weight.
CONCLUSIONS NlmCategory: CONCLUSIONS
Consistent with previous studies in singleton children, lower birth weight is associated with shorter axial length and more curved corneas in this twin study. This also adds new insights into the emmetropization process.
Copyright 2010 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2010 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2010/03/24
revised 2010/06/18
accepted 2010/06/19
entrez 2010/10/26 06:00
pubmed 2010/10/26 06:00
medline 2010/12/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Sun C Sun Cong C Centre for Eye Research, University of Melbourne, Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
Ponsonby AL Ponsonby Anne-Louise AL
Brown SA Brown Shayne A SA
Kearns LS Kearns Lisa S LS
Mackinnon JR Mackinnon Jane R JR
Barbour JM Barbour Julie M JM
Ruddle JB Ruddle Jonathan B JB
Hewitt AW Hewitt Alex W AW
Wright MJ Wright Margret J MJ
Martin NG Martin Nicholas G NG
Dwyer T Dwyer Terence T
Mackey DA Mackey David A DA
INVESTIGATORS
JOURNAL
VOLUME: 150
ISSUE: 6
TITLE: American journal of ophthalmology
ISOABBREVIATION: Am. J. Ophthalmol.
YEAR: 2010
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1879-1891
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Ophthalmol
COUNTRY: United States
ISSNLINKING: 0002-9394
NLMUNIQUEID: 0370500
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Australia
Biometry
Birth Weight physiology
Child physiology
Child, Preschool physiology
Cross-Sectional Studies physiology
Endophenotypes physiology
Eye anatomy & histology
Female anatomy & histology
Glaucoma pathology
Humans pathology
Male pathology
Middle Aged pathology
Refraction, Ocular physiology
Surveys and Questionnaires physiology
Twins, Dizygotic physiology
Twins, Monozygotic physiology
Young Adult physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's