Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
20950689
TITLE
Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29.
ABSTRACT
White matter microstructure is under strong genetic control, yet it is largely unknown how genetic influences change from childhood into adulthood. In one of the largest brain mapping studies ever performed, we determined whether the genetic control over white matter architecture depends on age, sex, socioeconomic status (SES), and intelligence quotient (IQ). We assessed white matter integrity voxelwise using diffusion tensor imaging at high magnetic field (4-Tesla), in 705 twins and their siblings (age range 12-29; 290 M/415 F). White matter integrity was quantified using a widely accepted measure, fractional anisotropy (FA). We fitted gene-environment interaction models pointwise, to visualize brain regions where age, sex, SES and IQ modulate heritability of fiber integrity. We hypothesized that environmental factors would start to outweigh genetic factors during late childhood and adolescence. Genetic influences were greater in adolescence versus adulthood, and greater in males than in females. Socioeconomic status significantly interacted with genes that affect fiber integrity: heritability was higher in those with higher SES. In people with above-average IQ, genetic factors explained over 80% of the observed FA variability in the thalamus, genu, posterior internal capsule, and superior corona radiata. In those with below-average IQ, however, only around 40% FA variability in the same regions was attributable to genetic factors. Genes affect fiber integrity, but their effects vary with age, sex, SES and IQ. Gene-environment interactions are vital to consider in the search for specific genetic polymorphisms that affect brain integrity and connectivity.
Copyright 2010 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2011 Feb 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2010/08/15
revised 2010/09/18
accepted 2010/10/05
aheadofprint 2010/10/13
entrez 2010/10/19 06:00
pubmed 2010/10/19 06:00
medline 2011/04/01 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Chiang MC Chiang Ming-Chang MC Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-7332, USA.
McMahon KL McMahon Katie L KL
de Zubicaray GI de Zubicaray Greig I GI
Martin NG Martin Nicholas G NG
Hickie I Hickie Ian I
Toga AW Toga Arthur W AW
Wright MJ Wright Margaret J MJ
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME: 54
ISSUE: 3
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2011
MONTH: Feb
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AG016570 NIA NIH HHS United States
EB01651 NIBIB NIH HHS United States
P50 AG016570-12 NIA NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 HD050735-04 NICHD NIH HHS United States
R21 RR019771 NCRR NIH HHS United States
R21 RR019771-02 NCRR NIH HHS United States
RR019771 NCRR NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aging physiology
Algorithms physiology
Anisotropy physiology
Brain growth & development
Child growth & development
Diffusion Tensor Imaging growth & development
Environment growth & development
Female growth & development
Genetic Linkage growth & development
Genetics growth & development
Humans growth & development
Image Processing, Computer-Assisted growth & development
Intelligence Tests growth & development
Male growth & development
Sex Characteristics growth & development
Siblings growth & development
Social Class growth & development
Twins growth & development
Young Adult growth & development
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS250168 NLM
PMC3197836 NLM