Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
20707712
TITLE
A genome-wide association study of self-rated health.
ABSTRACT
Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18-92. No genome wide significant SNPs associated with self-rated health could be identified, indicating that self-rated health may be influenced by a large number of SNPs with very small effect size. A very large sample will be needed to identify these SNPs.
DATE PUBLISHED
2010 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2010/08/17 06:00
pubmed 2010/08/17 06:00
medline 2011/02/25 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Mosing MA Mosing Miriam A MA Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Miriam.Mosing@qimir.edu.au
Verweij KJ Verweij Karin J H KJ
Medland SE Medland Sarah E SE
Painter J Painter Jodie J
Gordon SD Gordon Scott D SD
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A PA
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 13
ISSUE: 4
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2010
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites J Aging Health. 1999 Feb;11(1):49-64 10848141
Cites J Aging Health. 2000 May;12(2):169-92 11010695
Cites Health Serv Res. 2000 Dec;35(5 Pt 1):995-1010 11130808
Cites J Gerontol B Psychol Sci Soc Sci. 2001 May;56(3):S171-8 11316842
Cites Aging (Milano). 2001 Dec;13(6):454-64 11845973
Cites Clin Orthop Relat Res. 2003 Aug;(413):90-105 12897600
Cites J Gerontol. 1992 May;47(3):P213-20 1573207
Cites J Gerontol. 1992 Nov;47(6):P373-84 1430859
Cites J Gerontol. 1993 Nov;48(6):S289-300 8228003
Cites Scand J Soc Med. 1996 Sep;24(3):218-24 8878376
Cites Psychol Med. 1997 Nov;27(6):1381-96 9403910
Cites J Am Geriatr Soc. 2005 Jun;53(6):1002-7 15935024
Cites Health Econ. 2007 Feb;16(2):163-78 16941555
Cites Behav Genet. 2007 Mar;37(2):326-33 16906466
Cites Am J Hum Genet. 2007 Nov;81(5):913-26 17924335
Cites Genet Epidemiol. 2008 Apr;32(3):227-34 18300295
Cites Twin Res Hum Genet. 2008 Jun;11(3):287-305 18498207
Cites J Thromb Haemost. 2008 Oct;6(10):1625-32 18680534
Cites Cancer Prev Res (Phila). 2009 Jul;2(7):617-24 19584075
Cites Gut. 2009 Aug;58(8):1078-83 19240061
Cites Nature. 2009 Aug 6;460(7256):748-52 19571811
Cites Depress Anxiety. 2009;26(11):1004-11 19750555
Cites Am J Hum Genet. 2009 Nov;85(5):750-5 19896111
Cites Behav Genet. 2009 Nov;39(6):597-604 19618259
Cites Nat Genet. 2010 Jul;42(7):565-9 20562875
Cites Am J Hum Genet. 2010 Jul 9;87(1):139-45 20598278
Cites Biol Psychol. 2010 Oct;85(2):306-17 20691247
Cites Nature. 2010 Oct 14;467(7317):832-8 20881960
GRANTS
GRANTID AGENCY COUNTRY
R01 AA007535 NIAAA NIH HHS United States
R01 AA007535-08 NIAAA NIH HHS United States
R01 MH066206-05 NIMH NIH HHS United States
R01 AA014041 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
R01 AA010249-04 NIAAA NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
R01 AA014041-05 NIAAA NIH HHS United States
R01 AA013326 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA012854-08 NIDA NIH HHS United States
R01 AA013321-05 NIAAA NIH HHS United States
R01 AA013320-05 NIAAA NIH HHS United States
R01 AA013326-05 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Australia
Female
Genome-Wide Association Study
Health Status
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Self-Assessment
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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