|
|
| PMID |
|
|
| TITLE |
|
| The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. |
|
| ABSTRACT |
|
|
|
| The perceived taste intensities of quinine HCl, caffeine, sucrose octaacetate (SOA) and propylthiouracil (PROP) solutions were examined in 1457 twins and their siblings. Previous heritability modeling of these bitter stimuli indicated a common genetic factor for quinine, caffeine and SOA (22-28%), as well as separate specific genetic factors for PROP (72%) and quinine (15%). To identify the genes involved, we performed a genome-wide association study with the same sample as the modeling analysis, genotyped for approximately 610,000 single-nucleotide polymorphisms (SNPs). For caffeine and SOA, no SNP association reached a genome-wide statistical criterion. For PROP, the peak association was within TAS2R38 (rs713598, A49P, P = 1.6 × 10(-104)), which accounted for 45.9% of the trait variance. For quinine, the peak association was centered in a region that contains bitter receptor as well as salivary protein genes and explained 5.8% of the trait variance (TAS2R19, rs10772420, R299C, P = 1.8 × 10(-15)). We confirmed this association in a replication sample of twins of similar ancestry (P = 0.00001). The specific genetic factor for the perceived intensity of PROP was identified as the gene previously implicated in this trait (TAS2R38). For quinine, one or more bitter receptor or salivary proline-rich protein genes on chromosome 12 have alleles which affect its perception but tight linkage among very similar genes precludes the identification of a single causal genetic variant. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2010/08/03 06:00 |
| pubmed |
2010/08/03 06:00 |
| medline |
2011/02/11 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Reed DR |
|
Reed |
Danielle R |
DR |
|
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. reed@monell.org |
| Zhu G |
|
Zhu |
Gu |
G |
|
|
| Breslin PA |
|
Breslin |
Paul A S |
PA |
|
|
| Duke FF |
|
Duke |
Fujiko F |
FF |
|
|
| Henders AK |
|
Henders |
Anjali K |
AK |
|
|
| Campbell MJ |
|
Campbell |
Megan J |
MJ |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Medland SE |
|
Medland |
Sarah E |
SE |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 19 |
| ISSUE: 21 |
| TITLE: Human molecular genetics |
| ISOABBREVIATION: Hum Mol Genet |
| YEAR: 2010 |
| MONTH: Nov |
| DAY: 01 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1460-2083 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Hum Mol Genet |
| COUNTRY: England |
| ISSNLINKING: 0964-6906 |
| NLMUNIQUEID: 9208958 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Cell. 2000 Mar 17;100(6):693-702 |
10761934 |
|
| Cites |
Chem Senses. 1998 Jun;23(3):327-32 |
9669045 |
|
| Cites |
Percept Psychophys. 2001 Jul;63(5):761-76 |
11521845 |
|
| Cites |
Science. 2003 Feb 21;299(5610):1221-5 |
12595690 |
|
| Cites |
Hum Genet. 2003 May;112(5-6):567-72 |
12624758 |
|
| Cites |
Mol Biol Evol. 2003 May;20(5):805-14 |
12679530 |
|
| Cites |
Nature. 2003 Dec 18;426(6968):789-96 |
14685227 |
|
| Cites |
Am J Hum Genet. 2004 Apr;74(4):637-46 |
14997422 |
|
| Cites |
Chem Senses. 2004 Oct;29(8):697-702 |
15466815 |
|
| Cites |
Ann Hum Genet. 1973 Oct;37(2):227-32 |
4797620 |
|
| Cites |
Am J Phys Anthropol. 1974 Jul;41(1):139-51 |
4135578 |
|
| Cites |
Genet Res. 1984 Oct;44(2):151-60 |
6510710 |
|
| Cites |
Ren Physiol Biochem. 1990 Jan-Apr;13(1-2):37-50 |
1689860 |
|
| Cites |
J Dent Res. 1990 Mar;69(3):838-43 |
2182682 |
|
| Cites |
Am J Hum Genet. 1999 May;64(5):1478-80 |
10205283 |
|
| Cites |
Chem Senses. 1999 Aug;24(4):373-85 |
10480673 |
|
| Cites |
Nature. 1963 Oct 26;200:343-7 |
14087884 |
|
| Cites |
Pediatrics. 2005 Feb;115(2):e216-22 |
15687429 |
|
| Cites |
Curr Biol. 2005 Feb 22;15(4):322-7 |
15723792 |
|
| Cites |
Curr Biol. 2005 Jul 26;15(14):1257-65 |
16051168 |
|
| Cites |
Hum Mutat. 2005 Sep;26(3):199-204 |
16086309 |
|
| Cites |
Chem Senses. 2006 Jun;31(5):403-13 |
16527870 |
|
| Cites |
Am J Physiol Gastrointest Liver Physiol. 2006 Aug;291(2):G171-7 |
16710053 |
|
| Cites |
Am J Physiol Cell Physiol. 2006 Oct;291(4):C726-39 |
16707556 |
|
| Cites |
Am J Hum Genet. 2007 Nov;81(5):913-26 |
17924335 |
|
| Cites |
J Clin Invest. 2008 Nov;118(11):3693-700 |
18846256 |
|
| Cites |
PLoS One. 2008;3(12):e3974 |
19092995 |
|
| Cites |
Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G971-81 |
19179623 |
|
| Cites |
Science. 2009 Aug 28;325(5944):1131-4 |
19628819 |
|
| Cites |
Biol Lett. 2009 Dec 23;5(6):809-11 |
19675003 |
|
| Cites |
Am J Hum Genet. 2009 Nov;85(5):750-5 |
19896111 |
|
| Cites |
Chem Senses. 2010 Feb;35(2):157-70 |
20022913 |
|
| Cites |
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3210-5 |
20133764 |
|
| Cites |
Chem Senses. 2010 Jun;35(5):395-406 |
20212011 |
|
| Cites |
Cell. 2000 Mar 17;100(6):703-11 |
10761935 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 DC004698 |
NIDCD NIH HHS |
United States |
| R03 DC003509 |
NIDCD NIH HHS |
United States |
| DC004698 |
NIDCD NIH HHS |
United States |
| DC02995 |
NIDCD NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Chromosomes, Human, Pair 12 |
|
| Genetic Variation |
|
| Humans |
|
| Polymorphism, Single Nucleotide |
|
| Quinine |
|
| Taste Buds |
metabolism |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| A7V27PHC7A |
Quinine |
|
| OTHER ID's |
|
|
|
