Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
20402985
TITLE
Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Because cannabis use is associated with social, physical and psychological problems, it is important to know what causes some individuals to initiate cannabis use and a subset of those to become problematic users. Previous twin studies found evidence for both genetic and environmental influences on vulnerability, but due to considerable variation in the results it is difficult to draw clear conclusions regarding the relative magnitude of these influences.
METHODS NlmCategory: METHODS
Because cannabis use is associated with social, physical and psychological problems, it is important to know what causes some individuals to initiate cannabis use and a subset of those to become problematic users. Previous twin studies found evidence for both genetic and environmental influences on vulnerability, but due to considerable variation in the results it is difficult to draw clear conclusions regarding the relative magnitude of these influences. A systematic literature search identified 28 twin studies on cannabis use initiation and 24 studies on problematic cannabis use. The proportion of total variance accounted for by genes (A), shared environment (C) and unshared environment (E) in (i) initiation of cannabis use and (ii) problematic cannabis use was calculated by averaging corresponding A, C and E estimates across studies from independent cohorts and weighting by sample size.
RESULTS NlmCategory: RESULTS
Because cannabis use is associated with social, physical and psychological problems, it is important to know what causes some individuals to initiate cannabis use and a subset of those to become problematic users. Previous twin studies found evidence for both genetic and environmental influences on vulnerability, but due to considerable variation in the results it is difficult to draw clear conclusions regarding the relative magnitude of these influences. A systematic literature search identified 28 twin studies on cannabis use initiation and 24 studies on problematic cannabis use. The proportion of total variance accounted for by genes (A), shared environment (C) and unshared environment (E) in (i) initiation of cannabis use and (ii) problematic cannabis use was calculated by averaging corresponding A, C and E estimates across studies from independent cohorts and weighting by sample size. For cannabis use initiation, A, C and E estimates were 48%, 25% and 27% in males and 40%, 39% and 21% in females. For problematic cannabis use A, C and E estimates were 51%, 20% and 29% for males and 59%, 15% and 26% for females. Confidence intervals of these estimates are considerably narrower than those in the source studies.
CONCLUSIONS NlmCategory: CONCLUSIONS
Because cannabis use is associated with social, physical and psychological problems, it is important to know what causes some individuals to initiate cannabis use and a subset of those to become problematic users. Previous twin studies found evidence for both genetic and environmental influences on vulnerability, but due to considerable variation in the results it is difficult to draw clear conclusions regarding the relative magnitude of these influences. A systematic literature search identified 28 twin studies on cannabis use initiation and 24 studies on problematic cannabis use. The proportion of total variance accounted for by genes (A), shared environment (C) and unshared environment (E) in (i) initiation of cannabis use and (ii) problematic cannabis use was calculated by averaging corresponding A, C and E estimates across studies from independent cohorts and weighting by sample size. For cannabis use initiation, A, C and E estimates were 48%, 25% and 27% in males and 40%, 39% and 21% in females. For problematic cannabis use A, C and E estimates were 51%, 20% and 29% for males and 59%, 15% and 26% for females. Confidence intervals of these estimates are considerably narrower than those in the source studies. Our results indicate that vulnerability to both cannabis use initiation and problematic use was influenced significantly by A, C and E. There was a trend for a greater C and lesser A component for cannabis use initiation compared to problematic use for females.
DATE PUBLISHED
2010 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2010/04/21 06:00
pubmed 2010/04/21 06:00
medline 2010/09/21 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Verweij KJ Verweij Karin J H KJ Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Qld, Australia.
Zietsch BP Zietsch Brendan P BP
Lynskey MT Lynskey Michael T MT
Medland SE Medland Sarah E SE
Neale MC Neale Michael C MC
Martin NG Martin Nicholas G NG
Boomsma DI Boomsma Dorret I DI
Vink JM Vink Jacqueline M JM
INVESTIGATORS
JOURNAL
VOLUME: 105
ISSUE: 3
TITLE: Addiction (Abingdon, England)
ISOABBREVIATION: Addiction
YEAR: 2010
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1360-0443
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Addiction
COUNTRY: England
ISSNLINKING: 0965-2140
NLMUNIQUEID: 9304118
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 DA018267 NIDA NIH HHS United States
R01 DA018267-05 NIDA NIH HHS United States
DA018267 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
cannabis
genetics
heritability
meta-analysis
twin research
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Child
Diseases in Twins psychology
Female psychology
Genetic Predisposition to Disease psychology
Humans psychology
Male psychology
Marijuana Abuse psychology
Middle Aged psychology
Phenotype psychology
Risk Factors psychology
Sex Factors psychology
Social Environment psychology
Twin Studies as Topic psychology
Young Adult psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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Last Modified: Oct 15 2007