Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
20397748
TITLE
Genome-wide association study of height and body mass index in Australian twin families.
ABSTRACT
Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at approximately 550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value=1.06x10(-9)) located in HHIP, a well-replicated height-associated gene. Suggestive levels of association were found for other known genes associated with height (P values<1x10(-6)): ADAMTSL3, EFEMP1, GPR126, and HMGA2; and BMI (P values<1x10(-4)): FTO and MC4R. Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI.
DATE PUBLISHED
2010 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2010/04/20 06:00
pubmed 2010/04/20 06:00
medline 2010/08/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Liu JZ Liu Jimmy Z JZ Queensland Statistical Genetics, Genetic Epidemiology and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Australia.
Medland SE Medland Sarah E SE
Wright MJ Wright Margaret J MJ
Henders AK Henders Anjali K AK
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
Duncan A Duncan Alexis A
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
McRae AF McRae Allan F AF
INVESTIGATORS
JOURNAL
VOLUME: 13
ISSUE: 2
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2010
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 AA007535 NIAAA NIH HHS United States
R01 AA007535-08 NIAAA NIH HHS United States
R01 MH066206-05 NIMH NIH HHS United States
R01 AA014041 NIAAA NIH HHS United States
R01 AA010249-04 NIAAA NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
R01 AA014041-05 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
DA12854 NIDA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
R01 AA013326 NIAAA NIH HHS United States
R56 DA012854 NIDA NIH HHS United States
MH66206 NIMH NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 AA013321-05 NIAAA NIH HHS United States
R01 AA013320-05 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
R01 AA013326-05 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
R01 DA012854-07 NIDA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Body Mass Index
Family
Female
Genetic Variation
Genome, Human
Genome-Wide Association Study
Genotype
Humans
Male
Polymorphism, Single Nucleotide
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's