Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
20303062
TITLE
A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure.
ABSTRACT
The ratio of the lengths of an individual's second to fourth digit (2D:4D) is commonly used as a noninvasive retrospective biomarker for prenatal androgen exposure. In order to identify the genetic determinants of 2D:4D, we applied a genome-wide association approach to 1507 11-year-old children from the Avon Longitudinal Study of Parents and Children (ALSPAC) in whom 2D:4D ratio had been measured, as well as a sample of 1382 12- to 16-year-olds from the Brisbane Adolescent Twin Study. A meta-analysis of the two scans identified a single variant in the LIN28B gene that was strongly associated with 2D:4D (rs314277: p = 4.1 x 10(-8)) and was subsequently independently replicated in an additional 3659 children from the ALSPAC cohort (p = 1.53 x 10(-6)). The minor allele of the rs314277 variant has previously been linked to increased height and delayed age at menarche, but in our study it was associated with increased 2D:4D in the direction opposite to that of previous reports on the correlation between 2D:4D and age at menarche. Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure.
(c) 2010 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.
DATE PUBLISHED
2010 Apr 09
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2009/11/26
revised 2010/01/27
accepted 2010/02/12
entrez 2010/03/23 06:00
pubmed 2010/03/23 06:00
medline 2010/04/23 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Medland SE Medland Sarah E SE Genetic Epidemiology, Queensland Institute of Medical Research, Australia.
Zayats T Zayats Tetyana T
Glaser B Glaser Beate B
Nyholt DR Nyholt Dale R DR
Gordon SD Gordon Scott D SD
Wright MJ Wright Margaret J MJ
Montgomery GW Montgomery Grant W GW
Campbell MJ Campbell Megan J MJ
Henders AK Henders Anjali K AK
Timpson NJ Timpson Nicholas J NJ
Peltonen L Peltonen Leena L
Wolke D Wolke Dieter D
Ring SM Ring Susan M SM
Deloukas P Deloukas Panos P
Martin NG Martin Nicholas G NG
Smith GD Smith George Davey GD
Evans DM Evans David M DM
INVESTIGATORS
JOURNAL
VOLUME: 86
ISSUE: 4
TITLE: American journal of human genetics
ISOABBREVIATION: Am J Hum Genet
YEAR: 2010
MONTH: Apr
DAY: 09
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1537-6605
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Hum Genet
COUNTRY: United States
ISSNLINKING: 0002-9297
NLMUNIQUEID: 0370475
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
G0600705 Medical Research Council United Kingdom
G0800582 Medical Research Council United Kingdom
90600705 Medical Research Council United Kingdom
Wellcome Trust United Kingdom
G9815508 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Anthropometry
Biomarkers
Child
Cohort Studies
Female
Fingers anatomy & histology
Genetic Variation anatomy & histology
Genotype anatomy & histology
Humans anatomy & histology
Longitudinal Studies anatomy & histology
Male anatomy & histology
Meta-Analysis as Topic anatomy & histology
Pregnancy anatomy & histology
Prenatal Exposure Delayed Effects genetics
RNA-Binding Proteins genetics
Testosterone physiology
Twin Studies as Topic physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Biomarkers
0 Lin28A protein, human
0 RNA-Binding Proteins
3XMK78S47O Testosterone
OTHER ID's
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