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PMID |
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TITLE |
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Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. |
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ABSTRACT |
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Abnormal expansion or depletion of particular lymphocyte subsets is associated with clinical manifestations such as HIV progression to AIDS and autoimmune disease. We sought to identify genetic predictors of lymphocyte levels and reasoned that these may play a role in immune-related diseases. We tested 2.3 million variants for association with five lymphocyte subsets, measured in 2538 individuals from the general population, including CD4+ T cells, CD8+ T cells, CD56+ natural killer (NK) cells, and the derived measure CD4:CD8 ratio. We identified two regions of strong association. The first was located in the major histocompatibility complex (MHC), with multiple SNPs strongly associated with CD4:CD8 ratio (rs2524054, p = 2.1 x 10(-28)). The second region was centered within a cluster of genes from the Schlafen family and was associated with NK cell levels (rs1838149, p = 6.1 x 10(-14)). The MHC association with CD4:CD8 replicated convincingly (p = 1.4 x 10(-9)) in an independent panel of 988 individuals. Conditional analyses indicate that there are two major independent quantitative trait loci (QTL) in the MHC region that regulate CD4:CD8 ratio: one is located in the class I cluster and influences CD8 levels, whereas the second is located in the class II cluster and regulates CD4 levels. Jointly, both QTL explained 8% of the variance in CD4:CD8 ratio. The class I variants are also strongly associated with durable host control of HIV, and class II variants are associated with type-1 diabetes, suggesting that genetic variation at the MHC may predispose one to immune-related diseases partly through disregulation of T cell homeostasis. |
2010 The American Society of Human Genetics. Published by Elsevier Inc. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2009/11/04 |
revised |
2009/12/09 |
accepted |
2009/12/10 |
entrez |
2010/01/05 06:00 |
pubmed |
2010/01/05 06:00 |
medline |
2010/02/26 06:00 |
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AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Ferreira MA |
|
Ferreira |
Manuel A R |
MA |
|
Queensland Institute of Medical Research, Brisbane, QLD, Australia. manuel.ferreira@qimr.edu.au |
Mangino M |
|
Mangino |
Massimo |
M |
|
|
Brumme CJ |
|
Brumme |
Chanson J |
CJ |
|
|
Zhao ZZ |
|
Zhao |
Zhen Zhen |
ZZ |
|
|
Medland SE |
|
Medland |
Sarah E |
SE |
|
|
Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
Nyholt DR |
|
Nyholt |
Dale R |
DR |
|
|
Gordon S |
|
Gordon |
Scott |
S |
|
|
Campbell M |
|
Campbell |
Megan |
M |
|
|
McEvoy BP |
|
McEvoy |
Brian P |
BP |
|
|
Henders A |
|
Henders |
Anjali |
A |
|
|
Evans DM |
|
Evans |
David M |
DM |
|
|
Lanchbury JS |
|
Lanchbury |
Jerry S |
JS |
|
|
Pereyra F |
|
Pereyra |
Florencia |
F |
|
|
|
International HIV Controllers Study |
|
|
|
|
|
Walker BD |
|
Walker |
Bruce D |
BD |
|
|
Haas DW |
|
Haas |
David W |
DW |
|
|
Soranzo N |
|
Soranzo |
Nicole |
N |
|
|
Spector TD |
|
Spector |
Tim D |
TD |
|
|
de Bakker PI |
|
de Bakker |
Paul I W |
PI |
|
|
Frazer IH |
|
Frazer |
Ian H |
IH |
|
|
Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
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INVESTIGATORS |
|
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
Agan |
Brian |
B |
|
Agarwal |
Shanu |
S |
|
Allen |
Brady |
B |
|
Altidor |
Sherly |
S |
|
Altschuler |
Eric |
E |
|
Ambardar |
Sujata |
S |
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Anastos |
Kathryn |
K |
|
Anderson |
Ben |
B |
|
Andrady |
Ushan |
U |
|
Angell |
Teresa |
T |
|
Appelbaum |
Jonathan |
J |
|
Arnold |
Kathy |
K |
|
Arroyo |
Julio |
J |
|
Arthur |
Ernie |
E |
|
Barbaro |
Daniel |
D |
|
Barrett |
Tom |
T |
|
Barrie |
William |
W |
|
Barthel |
Vincent |
V |
|
Bartlett |
Mary E |
ME |
|
Barton |
Simon |
S |
|
Basden |
Pat |
P |
|
Basgoz |
Nesli |
N |
|
Bellos |
Nicholas |
N |
|
Berger |
Judith |
J |
|
Bernard |
Annette |
A |
|
Bernard |
Nicole |
N |
|
Blair |
Donald |
D |
|
Bodner |
Stanley |
S |
|
Bolan |
Robert |
R |
|
Boudreaux |
Emilie |
E |
|
Braun |
James |
J |
|
Brndjar |
Jon |
J |
|
Brooks |
Edward |
E |
|
Brown |
Kathy |
K |
|
Brown |
Stephen |
S |
|
Bryant |
Susan |
S |
|
Bryson |
Rena |
R |
|
Buchbinder |
Susan |
S |
|
Bullock |
Diane |
D |
|
Burack |
Jedidah |
J |
|
Busalacchi |
Mary |
M |
|
Bush |
Larry |
L |
|
Cafaro |
Virginia |
V |
|
Campbell |
John |
J |
|
Cardosi |
Beth |
B |
|
Carlson |
Rob |
R |
|
Carmichael |
Kevin |
K |
|
Carr |
Pat |
P |
|
Carrington |
Mary |
M |
|
Cavacuiti |
Chris |
C |
|
Celestin |
Greg |
G |
|
Chaborek |
Michele |
M |
|
Chau |
John |
J |
|
Chez |
Nancy |
N |
|
Cimoch |
Paul |
P |
|
Cohen |
Daniel E |
DE |
|
Cohn |
Bruce |
B |
|
Cohn |
Lillian |
L |
|
Conway |
Brian |
B |
|
Cooper |
David |
D |
|
Cooper |
Julie |
J |
|
Cornellson |
Brian |
B |
|
Cowles |
Anastacia |
A |
|
Cox |
David |
D |
|
Cox-Iyamu |
Roxanne |
R |
|
Cuchural |
George |
G |
|
Daily |
Michael |
M |
|
Daly |
Jennifer |
J |
|
Dang |
Son |
S |
|
Davis |
Benjamin |
B |
|
Davis |
Kristine |
K |
|
De Koning |
P |
P |
|
DeCardi Hladek |
Melissa |
M |
|
Dechter |
Mark |
M |
|
Deeks |
Steven |
S |
|
DeFoto |
Joseph |
J |
|
DeJesus |
Edwin |
E |
|
Dennis |
Deborah T |
DT |
|
Dolan |
Matthew |
M |
|
Duggan |
Joan |
J |
|
Dunn |
Michael |
M |
|
Egenes |
Karen |
K |
|
Ellerin |
Todd |
T |
|
Elliott |
Kathy |
K |
|
Eron |
Joe |
J |
|
Fangman |
John |
J |
|
Ferlazzo |
Helen |
H |
|
Figueroa |
Yvette |
Y |
|
Fiola |
Terri |
T |
|
Fisk |
Stuart |
S |
|
Flaherty |
Maureen |
M |
|
Fleenor-Ford |
Anita |
A |
|
Forster |
Alice |
A |
|
Fralich |
Todd |
T |
|
Francke |
Elliott |
E |
|
Frankel |
Renee |
R |
|
Freedburg |
Kenneth |
K |
|
French |
Neel |
N |
|
Fuchs |
Jonathan D |
JD |
|
Fuller |
John |
J |
|
Gaberman |
Jonna I |
JI |
|
Gallant |
Joel |
J |
|
Gandhi |
Rajesh |
R |
|
Ganesan |
Anurdha |
A |
|
Garcia |
Efrain |
E |
|
Gardner |
Adrian |
A |
|
Garver |
Patricia |
P |
|
Gastaldo |
Joseph |
J |
|
Gathe |
Joseph |
J |
|
Gaultier |
Cyril |
C |
|
Gebre |
Wondwoosen |
W |
|
Gelman |
Marcy |
M |
|
Gilman |
Frank |
F |
|
Gilmore |
John |
J |
|
Gimbarevsky |
Boris |
B |
|
Glaser |
Jordan |
J |
|
Goepfert |
Paul |
P |
|
Good |
Gary |
G |
|
Gottlieb |
Michael |
M |
|
Goulston |
Claudia |
C |
|
Grimm |
William |
W |
|
Groger |
Richard |
R |
|
Guiteau |
Jacques |
J |
|
Gurley |
T Douglas |
TD |
|
Haber |
Stuart |
S |
|
Hale |
Braden |
B |
|
Halpenny |
Roberta |
R |
|
Hardin |
Theresa |
T |
|
Hardy |
W David |
WD |
|
Hargan |
Todd |
T |
|
Harrigan |
Richard |
R |
|
Haston |
Janna |
J |
|
Hawkins |
Trevor |
T |
|
Hellinger |
Walter |
W |
|
Henderson |
Robert |
R |
|
Henderson |
Tom |
T |
|
Henry |
Keith |
K |
|
Hermann |
Susan |
S |
|
Hernandez |
Salvador |
S |
|
Hicks |
Claire |
C |
|
Hoffman |
Robert |
R |
|
Holland |
Chris |
C |
|
Horton |
James |
J |
|
Hoskinson |
Scott |
S |
|
Hsu |
Ricky K |
RK |
|
Huber |
Janice |
J |
|
Huhn |
Gregory |
G |
|
Humphrey |
Rene |
R |
|
Hupert |
Mark |
M |
|
Hurtado |
Rocio |
R |
|
Illeman |
Mark |
M |
|
Israelski |
Dennis |
D |
|
Jellinger |
Robert |
R |
|
Jessen |
Heiko |
H |
|
John |
Mina |
M |
|
Johnson |
Kay |
K |
|
Jones |
Mary |
M |
|
Jordan |
Wilbert |
W |
|
Kauffman |
Carol |
C |
|
Keba |
Anna |
A |
|
Khanlou |
Homayoon |
H |
|
Killian |
Rob |
R |
|
Kim |
Arthur |
A |
|
Kim |
David |
D |
|
Kinder |
Ford |
F |
|
Kirchner |
Jeff |
J |
|
Kish |
Mary Ann |
MA |
|
Kocurek |
Kathryn |
K |
|
Kogelman |
Laura |
L |
|
Kojic |
E Milu |
EM |
|
Kortuis |
Todd |
T |
|
Kovacs |
Julia |
J |
|
Kreiswirth |
Stacey |
S |
|
Kuldanek |
Greg |
G |
|
Kurisu |
Wayne |
W |
|
Lackey |
Phillip |
P |
|
Ladan |
Ahmadi |
A |
|
Lanzafame |
Massimiliano |
M |
|
Lederman |
Michael |
M |
|
Lee |
David |
D |
|
Lee |
Ed |
E |
|
Lee |
Jenny |
J |
|
Lee |
Marah |
M |
|
LeGrand |
James |
J |
|
Lemoine |
Janice |
J |
|
Levin |
Steve |
S |
|
Levy |
Jay |
J |
|
Liguori |
Michael |
M |
|
Lin |
Nina |
N |
|
Little |
Susan |
S |
|
Livine |
Richard |
R |
|
Llibre |
Josep M |
JM |
|
Lopez |
Al |
A |
|
Loutfy |
Mona |
M |
|
Loy |
Dawn |
D |
|
Lubarda |
Barbara |
B |
|
Magee |
Thomas |
T |
|
Maksvytis |
Harvey |
H |
|
Man |
Alan |
A |
|
Mancuso |
Stacey |
S |
|
Marconi |
Vincent |
V |
|
Markowitz |
Martin |
M |
|
Marques |
Rui |
R |
|
Martin |
William |
W |
|
Mayer |
Gal |
G |
|
Mayer |
Kenneth |
K |
|
McCrone |
Cindy |
C |
|
McDonald |
Cheryl |
C |
|
McGhee |
Theresa |
T |
|
McIntyre |
Dawn |
D |
|
McLean |
P Scott |
PS |
|
McNett |
Michael |
M |
|
Mead |
Hazel |
H |
|
Mechling |
Katherine |
K |
|
Melia |
Michael |
M |
|
Metroka |
Craig |
C |
|
Meyer-Olson |
Dirk |
D |
|
Michael |
Brent |
B |
|
Miller |
Andy |
A |
|
Montana |
John |
J |
|
Montgomery |
Kate |
K |
|
Morice |
Anthony |
A |
|
Mounzer |
Karam |
K |
|
Munoz |
Michael |
M |
|
Nagin |
Iris |
I |
|
Nahass |
Ron |
R |
|
Ndung'u |
Thumbi |
T |
|
Nelson |
Sandra |
S |
|
Nielsen |
Craig |
C |
|
Norene |
David |
D |
|
Novales |
Susan |
S |
|
O'Connor |
David |
D |
|
O'Donnell |
Laura |
L |
|
Oldfield |
Edward |
E |
|
Olender |
Susan |
S |
|
Ojikutu |
Bisola |
B |
|
Owens |
William |
W |
|
Panzer |
Todd |
T |
|
Parks |
Brad |
B |
|
Pattison |
Julie |
J |
|
Pavlatos |
Andy |
A |
|
Perlmutter |
Aaron |
A |
|
Pierce |
Michael Norman |
MN |
|
Pollak |
Deborah |
D |
|
Rowe |
Emile |
E |
|
Pressnell |
Richard |
R |
|
Price |
Lawrence |
L |
|
Proia |
Laurie |
L |
|
Prokesch |
Richard |
R |
|
Prutch |
Peter |
P |
|
Pujet |
Heather |
H |
|
Rausch |
Michael |
M |
|
Ravinshankar |
Jayashree |
J |
|
Restrepo |
Dalilah |
D |
|
Rhame |
Frank |
F |
|
Richards |
Constance |
C |
|
Richman |
Douglas D |
DD |
|
Robbins |
Gregory |
G |
|
Rose |
Richard |
R |
|
Rosenthal |
Daniel |
D |
|
Ross |
Polly |
P |
|
Rubin |
David |
D |
|
Rumbaugh |
Elease |
E |
|
Sanchez |
Will |
W |
|
Sanjana |
Veeraf |
V |
|
Santiago |
Stephen |
S |
|
Santos |
Rene |
R |
|
Sax |
Paul |
P |
|
Scherman |
Debra |
D |
|
Schmidt |
Wolfgang |
W |
|
Shrader |
Shannon |
S |
|
Schuitemaker |
Hanneke |
H |
|
Scribner |
Anita |
A |
|
Sestak |
Phillip |
P |
|
Shalit |
Peter |
P |
|
Shay |
William |
W |
|
Sherman |
Jeffrey |
J |
|
Shirvani |
Vivian |
V |
|
Sims |
James |
J |
|
Sizemore |
Jay |
J |
|
Slotten |
Ross |
R |
|
Smiddy |
Joseph |
J |
|
Sokol-Anderson |
Marcia |
M |
|
Somogi |
Rachel |
R |
|
Sordjan |
Renee |
R |
|
Sosman |
James |
J |
|
Stabile |
Paul |
P |
|
Stapleton |
Jack |
J |
|
Starrett |
Sharee |
S |
|
Staszkow |
Kaleo |
K |
|
Stearn |
Ben |
B |
|
Stellbrink |
Hans-Jurgen |
HJ |
|
Sterman |
Lisa |
L |
|
Steyn |
Tinus |
T |
|
Stone |
David |
D |
|
Stone |
Valerie |
V |
|
Ta |
Ha |
H |
|
Tambussi |
Giuseppe |
G |
|
Taplitz |
Randy |
R |
|
Tashmia |
Karen |
K |
|
Tavari |
Daniel |
D |
|
Tedaldi |
Ellen |
E |
|
Telenti |
Amalio |
A |
|
Tierney |
Marianne |
M |
|
Tillquist |
Carolyn |
C |
|
Tosiello |
Lorraine |
L |
|
Tremblay |
Cécile |
C |
|
Triant |
Virginia Jeanne |
VJ |
|
Tribble |
Marc |
M |
|
Trinh |
P |
P |
|
Tuscher |
Susan |
S |
|
Vaccaro |
Anthony J |
AJ |
|
Valadas |
Emilia |
E |
|
Vecino |
Isabel |
I |
|
Wagner |
Theresa |
T |
|
Walworth |
Charles |
C |
|
Wanidworanun |
Chingchai |
C |
|
Ward |
Douglas |
D |
|
Warner |
Daniel |
D |
|
Watson |
Terry |
T |
|
Weber |
Karl |
K |
|
Weber |
Terry |
T |
|
Webster |
Duncan |
D |
|
Weinberg |
Winkler |
W |
|
Weintrob |
Amy |
A |
|
Weis |
Steve |
S |
|
Wenger |
Scott |
S |
|
Werntz |
Gary |
G |
|
Wheeler |
David |
D |
|
White |
David |
D |
|
Wilkins |
Ed |
E |
|
Winston |
Alan |
A |
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Wlodaver |
Clifford |
C |
|
Wolf |
Eva |
E |
|
Wright |
David |
D |
|
Yang |
Otto |
O |
|
Yawetz |
Sigal |
S |
|
Yurdin |
David L |
DL |
|
Zabukovic |
Brandon |
B |
|
Zachary |
Kimon |
K |
|
Zeeman |
Beth |
B |
|
Baker |
Brett |
B |
|
Block |
Brian |
B |
|
Braaten |
Conrad |
C |
|
Darrah |
Aisha Tiala |
AT |
|
LaTour |
Brooke |
B |
|
Lian |
Jeffrey |
J |
|
McClurg |
Cheryl |
C |
|
Piechocka-Trocha |
Alicja |
A |
|
Proudfoot |
Jacqueline |
J |
|
Rothchild |
Alissa |
A |
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Toth |
Ildiko |
I |
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Barefoot |
Laurie |
L |
|
Bazner |
Suzane |
S |
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Cutrell |
Emily |
E |
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Johnston |
Mary |
M |
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Lemay |
Paul |
P |
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Moss |
Kristin |
K |
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Oladehin |
Olakunle |
O |
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Rosenberg |
Rachel |
R |
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Tinsley |
Jake |
J |
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Tsao |
Alice |
A |
|
Pereyra |
Florencia |
F |
|
Addo |
Marylyn |
M |
|
Allen |
Todd |
T |
|
Alter |
Galit |
G |
|
Altfeld |
Marcus |
M |
|
Legall |
Sylvie |
S |
|
Pereyra |
Florencia |
F |
|
Walker |
Bruce |
B |
|
Yu |
Xu |
X |
|
Burtt |
Noël |
N |
|
Carmago |
Amy |
A |
|
Crawford |
Gabriel |
G |
|
Crenshaw |
Andrew |
A |
|
Davies |
Leela |
L |
|
Gabriel |
Stacey |
S |
|
Gianniny |
Lauren |
L |
|
Guiducci |
Candace |
C |
|
Brumme |
Chanson |
C |
|
de Bakker |
Paul |
P |
|
Jia |
Xiaoming |
X |
|
McLaren |
Paul |
P |
|
Haas |
David |
D |
|
Kuritzkes |
Daniel |
D |
|
Gulick |
Roy |
R |
|
Ribaudo |
Heather |
H |
|
Pereyra |
Florencia |
F |
|
Deeks |
Steve |
S |
|
de Bakker |
Paul |
P |
|
Carrington |
Mary |
M |
|
Allen |
Todd |
T |
|
Henn |
Matthew |
M |
|
Altfeld |
Marcus |
M |
|
Le Gall |
Sylvie |
S |
|
Heckerman |
David |
D |
|
Brumme |
Chanson |
C |
|
Walker |
Bruce |
B |
|
|
JOURNAL |
|
VOLUME: 86 |
ISSUE: 1 |
TITLE: American journal of human genetics |
ISOABBREVIATION: Am J Hum Genet |
YEAR: 2010 |
MONTH: Jan |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1537-6605 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Am J Hum Genet |
COUNTRY: United States |
ISSNLINKING: 0002-9297 |
NLMUNIQUEID: 0370475 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
|
COMMENTS AND CORRECTIONS |
|
REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
Cites |
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11196672 |
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Immunol Rev. 2009 Mar;228(1):41-57 |
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Genes Immun. 2009 Jun;10(4):334-40 |
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J Clin Invest. 2001 Jul;108(1):117-23 |
11435463 |
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Genes Immun. 2001 Nov;2(7):381-7 |
11704804 |
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Twin Res. 2002 Oct;5(5):440-3 |
12537873 |
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N Engl J Med. 1990 Jan 18;322(3):166-72 |
1967191 |
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Melanoma Res. 1996 Apr;6(2):155-65 |
8791274 |
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Immunity. 1998 Nov;9(5):657-68 |
9846487 |
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Genet Epidemiol. 1999;16(1):40-53 |
9915566 |
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Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18538-43 |
16344461 |
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Am J Hum Genet. 2006 Mar;78(3):480-6 |
16400618 |
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Cites |
Nature. 2007 Jun 7;447(7145):661-78 |
17554300 |
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Cites |
Nat Genet. 2007 Jul;39(7):906-13 |
17572673 |
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Nat Genet. 2007 Oct;39(10):1202-7 |
17873877 |
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Cites |
Am J Hum Genet. 2007 Nov;81(5):913-26 |
17924335 |
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Cites |
Nature. 2007 Dec 6;450(7171):887-92 |
18004301 |
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Cites |
Arthritis Res Ther. 2008;10(4):210 |
18710589 |
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Cites |
Adv Immunol. 2008;100:79-124 |
19111164 |
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Cites |
Nat Genet. 2009 Mar;41(3):342-7 |
19198610 |
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Cites |
Twin Res. 1999 Dec;2(4):250-7 |
10723803 |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
U01 AI069502 |
NIAID NIH HHS |
United States |
U01 AI069513 |
NIAID NIH HHS |
United States |
AI69467 |
NIAID NIH HHS |
United States |
UM1 AI069423 |
NIAID NIH HHS |
United States |
AI069415 |
NIAID NIH HHS |
United States |
AI069556 |
NIAID NIH HHS |
United States |
UM1 AI069501 |
NIAID NIH HHS |
United States |
UM1 AI069472 |
NIAID NIH HHS |
United States |
U01 AI069467 |
NIAID NIH HHS |
United States |
U01 AI069474 |
NIAID NIH HHS |
United States |
U01 AI069423 |
NIAID NIH HHS |
United States |
UM1 AI069513 |
NIAID NIH HHS |
United States |
AI069465 |
NIAID NIH HHS |
United States |
U01 AI069434 |
NIAID NIH HHS |
United States |
AI069419 |
NIAID NIH HHS |
United States |
AI069511 |
NIAID NIH HHS |
United States |
AI46370 |
NIAID NIH HHS |
United States |
AI077505 |
NIAID NIH HHS |
United States |
U01 AI027661 |
NIAID NIH HHS |
United States |
UM1 AI069424 |
NIAID NIH HHS |
United States |
R01 AI077505 |
NIAID NIH HHS |
United States |
G0600705 |
Medical Research Council |
United Kingdom |
G0800582 |
Medical Research Council |
United Kingdom |
U01 AI069465 |
NIAID NIH HHS |
United States |
UM1 AI069434 |
NIAID NIH HHS |
United States |
UM1 AI069432 |
NIAID NIH HHS |
United States |
AI069501 |
NIAID NIH HHS |
United States |
AI069532 |
NIAID NIH HHS |
United States |
AI069474 |
NIAID NIH HHS |
United States |
AI069434 |
NIAID NIH HHS |
United States |
UM1 AI069495 |
NIAID NIH HHS |
United States |
U01 AI069484 |
NIAID NIH HHS |
United States |
UM1 AI069471 |
NIAID NIH HHS |
United States |
U01 AI069556 |
NIAID NIH HHS |
United States |
UM1 AI069428 |
NIAID NIH HHS |
United States |
AI069513 |
NIAID NIH HHS |
United States |
AI069502 |
NIAID NIH HHS |
United States |
U01 AI069532 |
NIAID NIH HHS |
United States |
AI069423 |
NIAID NIH HHS |
United States |
U01 AI069428 |
NIAID NIH HHS |
United States |
UM1 AI069415 |
NIAID NIH HHS |
United States |
AI27661 |
NIAID NIH HHS |
United States |
UM1 AI069484 |
NIAID NIH HHS |
United States |
AI069428 |
NIAID NIH HHS |
United States |
AI34853 |
NIAID NIH HHS |
United States |
U01 AI069501 |
NIAID NIH HHS |
United States |
AI069452 |
NIAID NIH HHS |
United States |
AI069495 |
NIAID NIH HHS |
United States |
UM1 AI069477 |
NIAID NIH HHS |
United States |
U01 AI069432 |
NIAID NIH HHS |
United States |
AI069484 |
NIAID NIH HHS |
United States |
AI068636 |
NIAID NIH HHS |
United States |
U01 AI069450 |
NIAID NIH HHS |
United States |
RR024975 |
NCRR NIH HHS |
United States |
U01 AI046370 |
NIAID NIH HHS |
United States |
U01 AI068636 |
NIAID NIH HHS |
United States |
UM1 AI069474 |
NIAID NIH HHS |
United States |
U01 AI034853 |
NIAID NIH HHS |
United States |
UM1 AI069452 |
NIAID NIH HHS |
United States |
AI069424 |
NIAID NIH HHS |
United States |
U01 AI069415 |
NIAID NIH HHS |
United States |
U01 AI069495 |
NIAID NIH HHS |
United States |
UM1 AI069556 |
NIAID NIH HHS |
United States |
U01 AI069511 |
NIAID NIH HHS |
United States |
R01 MH071205 |
NIMH NIH HHS |
United States |
UM1 AI069502 |
NIAID NIH HHS |
United States |
U01 AI025859 |
NIAID NIH HHS |
United States |
UM1 AI069450 |
NIAID NIH HHS |
United States |
AI34835 |
NIAID NIH HHS |
United States |
MH071205 |
NIMH NIH HHS |
United States |
UM1 AI069532 |
NIAID NIH HHS |
United States |
UM1 AI069465 |
NIAID NIH HHS |
United States |
AL32782 |
PHS HHS |
United States |
UL1 RR024975 |
NCRR NIH HHS |
United States |
U01 AI069424 |
NIAID NIH HHS |
United States |
AI069450 |
NIAID NIH HHS |
United States |
AI069472 |
NIAID NIH HHS |
United States |
UM1 AI069419 |
NIAID NIH HHS |
United States |
AI069432 |
NIAID NIH HHS |
United States |
U01 AI069477 |
NIAID NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
U01 AI069419 |
NIAID NIH HHS |
United States |
AI25859 |
NIAID NIH HHS |
United States |
UM1 AI069511 |
NIAID NIH HHS |
United States |
U01 AI069452 |
NIAID NIH HHS |
United States |
UM1 AI069467 |
NIAID NIH HHS |
United States |
AI38844 |
NIAID NIH HHS |
United States |
AI069477 |
NIAID NIH HHS |
United States |
AI069471 |
NIAID NIH HHS |
United States |
U01 AI069471 |
NIAID NIH HHS |
United States |
U01 AI069472 |
NIAID NIH HHS |
United States |
UM1 AI068636 |
NIAID NIH HHS |
United States |
P30 AI050410 |
NIAID NIH HHS |
United States |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Adolescent |
|
CD4-Positive T-Lymphocytes |
immunology |
CD8-Positive T-Lymphocytes |
immunology |
Child |
immunology |
Diabetes Mellitus, Type 1 |
immunology |
Genetic Predisposition to Disease |
immunology |
Genetic Variation |
immunology |
Genotype |
immunology |
HIV Infections |
immunology |
HIV-1 |
metabolism |
Humans |
metabolism |
Killer Cells, Natural |
immunology |
Lymphocyte Count |
immunology |
Quantitative Trait Loci |
immunology |
Risk |
immunology |
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
|
OTHER ID's |
|
|
|