Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19943720
TITLE
A comprehensive neuropsychiatric study of elderly twins: the Older Australian Twins Study.
ABSTRACT
The Older Australian Twins Study (OATS) was recently initiated to investigate genetic and environmental factors and their associations and interactions in healthy brain ageing and ageing-related neurocognitive disorders. The study extends the classic MZ-DZ design to include one or two equivalently aged siblings for each twin pair and utilizes the rich resources of the Australian Twin Registry. The study has a number of distinguishing features including comprehensive psychiatric, neuropsychological, cardiovascular, metabolic, and neuroimaging assessments, a longitudinal design and links with a brain donor program. The study measures many behavioral and environmental factors, but in particular lifetime physical and mental activity, physical and psychological trauma, loss of parent early in life, later losses and life events, early-life socioeconomic environment, alcohol and drug use, occupational exposure, and nutrition. It also includes comprehensive cardiovascular assessment, blood biochemistry, genetics and proteomics. The socio-demographic and health data on the first 172 pairs of twins participating in this study are presented. Prevalence of mild cognitive impairment is 12.8% and of dementia 1.5% in the sample. The target sample size is 1000, with at least 400 pairs of twins aged 65-90 years. The cohort will be assessed every two years, with in-depth assessments being repeated. OATS offers an excellent opportunity for collaboration with other similar studies as well as researchers who share the same interests.
DATE PUBLISHED
2009 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2009/12/01 06:00
pubmed 2009/12/01 06:00
medline 2010/01/23 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Sachdev PS Sachdev Perminder S PS Brain & Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Australia. p.sachdev@unsw.edu.au
Lammel A Lammel Andrea A
Trollor JN Trollor Julian N JN
Lee T Lee Teresa T
Wright MJ Wright Margaret J MJ
Ames D Ames David D
Wen W Wen Wei W
Martin NG Martin Nicholas G NG
Brodaty H Brodaty Henry H
Schofield PR Schofield Peter R PR
OATS research team
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Azar Pamela P
Broe G Anthony GA
Graham Sara S
Halliday Glenda G
Harding Antony A
Kumfor Fiona F
Lux Ora O
Nichles Alissa A
Walker Alison A
Wong Alfred A
Zhang Jacqueline J
Beeby Harry H
Eldridge Ann A
Garden Natalie N
Grace Marlene M
Henders Anjali A
McMahon Katie K
Park Daniel D
Tovanen Amanda A
de Zubicaray Greig G
Cortes Nicholas N
De Mel Gihan G
Lemmon Christel C
Mangelsdorf Simone S
Walker Stacey S
JOURNAL
VOLUME: 12
ISSUE: 6
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2009
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Aged
Aged, 80 and over
Aging psychology
Australia psychology
Female psychology
Humans psychology
Longitudinal Studies psychology
Male psychology
Memory Disorders psychology
Registries psychology
Socioeconomic Factors psychology
Twins, Dizygotic psychology
Twins, Monozygotic psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's