Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19721450
TITLE
Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
To identify common loci and potential genetic variants affecting body mass index (BMI, kg m(-2)) in study populations originating from Europe.
DESIGN NlmCategory: METHODS
We combined genome-wide linkage scans of six cohorts from Australia, Denmark, Finland, the Netherlands, Sweden and the United Kingdom with an approximately 10-cM microsatellite marker map. Variance components linkage analysis was carried out with age, sex and country of origin as covariates.
SUBJECTS NlmCategory: METHODS
The GenomEUtwin consortium consists of twin cohorts from eight countries (Australia, Denmark, the Netherlands, Finland, Italy, Norway, Sweden and the United Kingdom) with a total data collection of more than 500,000 monozygotic and dizygotic (DZ) twin pairs. Variance due to early-life events and the environment is reduced within twin pairs, which makes DZ pairs highly valuable for linkage studies of complex traits. This study totaled 4401 European-originated twin families (10,535 individuals) from six countries (Australia, Denmark, the Netherlands, Finland, Sweden and the United Kingdom).
RESULTS NlmCategory: RESULTS
We found suggestive evidence for a quantitative trait locus on 3q29 and 7q36 in the combined sample of DZ twins (multipoint logarithm of odds score (MLOD) 2.6 and 2.4, respectively). Two individual cohorts showed strong evidence independently for three additional loci: 16q23 (MLOD=3.7) and 2p24 (MLOD=3.4) in the Dutch cohort and 20q13 (MLOD=3.2) in the Finnish cohort.
CONCLUSION NlmCategory: CONCLUSIONS
Linkage analysis of the combined data in this large twin cohort study provided evidence for suggestive linkage to BMI. In addition, two cohorts independently provided significant evidence of linkage to three new loci. The results of our study suggest a smaller environmental variance between DZ twins than full siblings, with a corresponding increase in heritability for BMI as well as an increase in linkage signal in well-replicated regions. The results are consistent with the possibility of locus heterogeneity for some genomic regions, and indicate a lack of major common quantitative trait locus variants affecting BMI in European populations.
DATE PUBLISHED
2009 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2009/09/01
entrez 2009/09/02 09:00
pubmed 2009/09/02 06:00
medline 2010/10/22 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kettunen J Kettunen J J Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. johannes@sanger.ac.uk
Perola M Perola M M
Martin NG Martin N G NG
Cornes BK Cornes B K BK
Wilson SG Wilson S G SG
Montgomery GW Montgomery G W GW
Benyamin B Benyamin B B
Harris JR Harris J R JR
Boomsma D Boomsma D D
Willemsen G Willemsen G G
Hottenga JJ Hottenga J-J JJ
Slagboom PE Slagboom P E PE
Christensen K Christensen K K
Kyvik KO Kyvik K O KO
Sørensen TI Sørensen T I A TI
Pedersen NL Pedersen N L NL
Magnusson PK Magnusson P K E PK
Andrew T Andrew T T
Spector TD Spector T D TD
Widen E Widen E E
Silventoinen K Silventoinen K K
Kaprio J Kaprio J J
Palotie A Palotie A A
Peltonen L Peltonen L L
GenomEUtwin-project
INVESTIGATORS
JOURNAL
VOLUME: 33
ISSUE: 11
TITLE: International journal of obesity (2005)
ISOABBREVIATION: Int J Obes (Lond)
YEAR: 2009
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5497
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Int J Obes (Lond)
COUNTRY: England
ISSNLINKING: 0307-0565
NLMUNIQUEID: 101256108
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Twin Res. 2003 Oct;6(5):409-21 14624725
Cites Diabetes. 2003 May;52(5):1284-7 12716766
Cites Twin Res. 2004 Apr;7(2):192-6 15181885
Cites Nat Genet. 1997 Mar;15(3):273-6 9054940
Cites Am J Hum Genet. 1998 Mar;62(3):659-68 9497255
Cites Behav Genet. 1997 Jul;27(4):325-51 9519560
Cites Am J Hum Genet. 1998 Jul;63(1):259-66 9634505
Cites Nat Genet. 1998 Nov;20(3):304-8 9806554
Cites Am J Hum Genet. 1999 Jan;64(1):196-209 9915959
Cites Diabetes. 1999 Sep;48(9):1863-7 10480620
Cites Nat Rev Genet. 2005 Mar;6(3):221-34 15703762
Cites Twin Res Hum Genet. 2005 Feb;8(1):16-21 15836805
Cites J Med Genet. 2005 Dec;42(12):932-9 15827092
Cites Twin Res Hum Genet. 2005 Dec;8(6):616-32 16363087
Cites Eur J Hum Genet. 2006 Mar;14(3):340-8 16391564
Cites Obesity (Silver Spring). 2006 Apr;14(4):529-644 16741264
Cites Int J Obes (Lond). 2006 Nov;30(11):1585-94 16801930
Cites Science. 2007 May 11;316(5826):889-94 17434869
Cites PLoS Genet. 2007 Jun;3(6):e97 17559308
Cites Obesity (Silver Spring). 2008 Apr;16(4):847-52 18239571
Cites Nat Genet. 2008 Jun;40(6):768-75 18454148
Cites Nat Genet. 2008 Jun;40(6):695-701 18509313
Cites PLoS One. 2008;3(8):e2958 18698412
Cites Nat Genet. 2009 Jan;41(1):18-24 19079260
Cites Nat Genet. 2009 Jan;41(1):25-34 19079261
Cites Eur J Hum Genet. 2009 Feb;17(2):258-66 18781184
Cites Nat Genet. 2009 Feb;41(2):157-9 19151714
Cites Behav Genet. 2009 Mar;39(2):154-64 19067155
Cites Int J Obes Relat Metab Disord. 2000 May;24(5):559-65 10849576
Cites J Clin Invest. 2000 Jul;106(2):253-62 10903341
Cites Arch Intern Med. 2000 Sep 25;160(17):2641-4 10999978
Cites Am J Hum Genet. 2000 Dec;67(6):1470-80 11067779
Cites Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14478-83 11121050
Cites J Clin Endocrinol Metab. 2001 Mar;86(3):1199-205 11238509
Cites Diabetes. 2001 Mar;50(3):614-21 11246882
Cites Am J Hum Genet. 2001 Jul;69(1):117-23 11410840
Cites Bioinformatics. 2001 Aug;17(8):742-3 11524377
Cites Hum Genet. 2001 Sep;109(3):279-85 11702208
Cites Hum Mol Genet. 2001 Nov 15;10(24):2751-65 11734540
Cites Am J Hum Genet. 2002 Jan;70(1):72-82 11713718
Cites Nat Genet. 2002 Jan;30(1):97-101 11731797
Cites Am J Hum Genet. 2002 May;70(5):1247-56 11923912
Cites Am J Hum Genet. 2003 Jan;72(1):115-24 12478478
Cites Am J Hum Genet. 2003 Feb;72(2):340-50 12506338
Cites Twin Res. 2002 Oct;5(5):329-36 12537854
Cites Twin Res. 2002 Oct;5(5):352-7 12537858
Cites Twin Res. 2002 Oct;5(5):358-65 12537859
Cites Twin Res. 2002 Oct;5(5):401-6 12537867
Cites Twin Res. 2002 Oct;5(5):427-32 12537870
Cites Twin Res. 2002 Oct;5(5):440-3 12537873
Cites N Engl J Med. 2003 Mar 20;348(12):1085-95 12646665
Cites Obes Res. 2004 Apr;12(4):577-81 15090624
GRANTS
GRANTID AGENCY COUNTRY
072856 Wellcome Trust United Kingdom
089061 Wellcome Trust United Kingdom
1-R01-HL087679-01 NHLBI NIH HHS United States
AA007535 NIAAA NIH HHS United States
AA013320 NIAAA NIH HHS United States
AA013326 NIAAA NIH HHS United States
AA014041 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
R01 MH059160 NIMH NIH HHS United States
Biotechnology and Biological Sciences Research Council United Kingdom
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Body Mass Index
Chromosomes, Human, Pair 3 genetics
Chromosomes, Human, Pair 7 genetics
Cohort Studies genetics
Europe genetics
European Continental Ancestry Group genetics
Female genetics
Genetic Linkage genetics
Genetic Predisposition to Disease genetics
Humans genetics
Male genetics
Microsatellite Repeats genetics
Middle Aged genetics
Quantitative Trait Loci genetics
Twins genetics
Twins, Dizygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC2873558 NLM
UKMS30431 NLM