PMID |
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TITLE |
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No association of DPP6 with amyotrophic lateral sclerosis in an Italian population. |
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ABSTRACT |
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We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts. |
Copyright © 2009 Elsevier Inc. All rights reserved. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2009/02/23 |
revised |
2009/05/07 |
accepted |
2009/05/12 |
aheadofprint |
2009/06/13 |
entrez |
2009/06/16 09:00 |
pubmed |
2009/06/16 09:00 |
medline |
2011/08/19 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Fogh I |
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Fogh |
Isabella |
I |
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MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, UK. I.Fogh@iop.kcl.ac.uk |
D'Alfonso S |
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D'Alfonso |
Sandra |
S |
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Gellera C |
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Gellera |
Cinzia |
C |
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Ratti A |
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Ratti |
Antonia |
A |
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Cereda C |
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Cereda |
Cristina |
C |
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Penco S |
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Penco |
Silvana |
S |
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Corrado L |
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Corrado |
Lucia |
L |
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Sorarù G |
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Sorarù |
Gianni |
G |
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Castellotti B |
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Castellotti |
Barbara |
B |
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Tiloca C |
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Tiloca |
Cinzia |
C |
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Gagliardi S |
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Gagliardi |
Stella |
S |
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Cozzi L |
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Cozzi |
Lorena |
L |
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Lupton MK |
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Lupton |
Michelle K |
MK |
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Ticozzi N |
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Ticozzi |
Nicola |
N |
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Mazzini L |
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Mazzini |
Letizia |
L |
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Shaw CE |
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Shaw |
Chris E |
CE |
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Al-Chalabi A |
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Al-Chalabi |
Ammar |
A |
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Powell J |
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Powell |
John |
J |
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Silani V |
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Silani |
Vincenzo |
V |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 32 |
ISSUE: 5 |
TITLE: Neurobiology of aging |
ISOABBREVIATION: Neurobiol. Aging |
YEAR: 2011 |
MONTH: May |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1558-1497 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Neurobiol Aging |
COUNTRY: United States |
ISSNLINKING: 0197-4580 |
NLMUNIQUEID: 8100437 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, Non-U.S. Gov't |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
089701 |
Wellcome Trust |
United Kingdom |
G0500289 |
Medical Research Council |
United Kingdom |
G0900688 |
Medical Research Council |
United Kingdom |
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Medical Research Council |
United Kingdom |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Amyotrophic Lateral Sclerosis |
genetics |
Cohort Studies |
genetics |
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases |
genetics |
Genetic Predisposition to Disease |
genetics |
Genome-Wide Association Study |
genetics |
Humans |
genetics |
Italy |
genetics |
Nerve Tissue Proteins |
genetics |
Polymorphism, Single Nucleotide |
genetics |
Potassium Channels |
genetics |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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REGISTRYNUMBER |
NAMEOFSUBSTANCE |
0 |
Nerve Tissue Proteins |
0 |
Potassium Channels |
EC 3.4.- |
DPP6 protein, human |
EC 3.4.14.- |
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases |
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OTHER ID's |
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