Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19525032
TITLE
No association of DPP6 with amyotrophic lateral sclerosis in an Italian population.
ABSTRACT
We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.
Copyright © 2009 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2011 May
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2009/02/23
revised 2009/05/07
accepted 2009/05/12
aheadofprint 2009/06/13
entrez 2009/06/16 09:00
pubmed 2009/06/16 09:00
medline 2011/08/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Fogh I Fogh Isabella I MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, UK. I.Fogh@iop.kcl.ac.uk
D'Alfonso S D'Alfonso Sandra S
Gellera C Gellera Cinzia C
Ratti A Ratti Antonia A
Cereda C Cereda Cristina C
Penco S Penco Silvana S
Corrado L Corrado Lucia L
Sorarù G Sorarù Gianni G
Castellotti B Castellotti Barbara B
Tiloca C Tiloca Cinzia C
Gagliardi S Gagliardi Stella S
Cozzi L Cozzi Lorena L
Lupton MK Lupton Michelle K MK
Ticozzi N Ticozzi Nicola N
Mazzini L Mazzini Letizia L
Shaw CE Shaw Chris E CE
Al-Chalabi A Al-Chalabi Ammar A
Powell J Powell John J
Silani V Silani Vincenzo V
INVESTIGATORS
JOURNAL
VOLUME: 32
ISSUE: 5
TITLE: Neurobiology of aging
ISOABBREVIATION: Neurobiol. Aging
YEAR: 2011
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1558-1497
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neurobiol Aging
COUNTRY: United States
ISSNLINKING: 0197-4580
NLMUNIQUEID: 8100437
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
089701 Wellcome Trust United Kingdom
G0500289 Medical Research Council United Kingdom
G0900688 Medical Research Council United Kingdom
Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Amyotrophic Lateral Sclerosis genetics
Cohort Studies genetics
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Humans genetics
Italy genetics
Nerve Tissue Proteins genetics
Polymorphism, Single Nucleotide genetics
Potassium Channels genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Nerve Tissue Proteins
0 Potassium Channels
EC 3.4.- DPP6 protein, human
EC 3.4.14.- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
OTHER ID's